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系統性硬化癥（SSc）是一種以血管異常、免疫活化及進行性多器官纖維化為特征的慢性自身免疫病。其核心病理機制包括自身抗體介導的B細胞異常活化、內皮損傷引發的血管病變，以及成纖維細胞激活導致的膠原過度沉積，最終引發皮膚、肺、心臟等器官纖維化。臨床分為局限型（lcSSc）和彌漫型皮膚硬化型（dcSSc），后者進展快、預后差，常伴間質性肺病（ILD）和心肌纖維化，致死率高。

當前系統性硬化癥（SSc）的治療依賴免疫抑制劑和抗纖維化藥，但療效有限且無法逆轉纖維化，研發聚焦于靶向致病B細胞、炎癥通路及纖維化逆轉：

● 雙靶點CAR-NK細胞療法（QN-139b）：全球首例由徐滬濟團隊應用于dcSSc的突破性療法。靶向CD19/BCMA雙抗原，通過iPSC來源的CAR-NK細胞清除致病B細胞和漿細胞，誘導免疫重建。

● JAK抑制劑（巴瑞替尼）：靶向JAK1/2通路，抑制炎癥因子信號，機制研究提示其下調促纖維化因子IL-1RL1（ST2）、上調再生相關蛋白SYT17。

系統性硬化癥在研藥物靶點

系統性硬化癥藥物靶點相關產品推薦

● 靶點蛋白

CLEC4C
CSB-MP855470HUh7

Measured by its binding ability in a functional ELISA. Immobilized Human CLEC4C at 2μg/mL can bind Anti-CLEC4C recombinant antibody (CSB-RA855470MA1HU)，the EC₅₀ is 7.658-12.99 ng/mL.

IL13
CSB-MP6408HU

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 2.045-6.215 ng/mL.

IL1RAP
CSB-MP878844HU

Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP at 2 μg/ml can bind Anti-IL1RAP recombinant antibody (CSB-RA878844MA1HU). The EC₅₀ is 0.9667-1.477 ng/mL.

TNFSF13B
CSB-MP897523HU1

Measured by its binding ability in a functional ELISA. Immobilized TNFSF13B at 10 μg/ml can bind human BCMA (CSB-MP023974HU1), the EC₅₀ of human TNFSF13B protein is 221.3-298.6 ng/ml.

Target	Product Name	Source	Tag Info	Code
CCL24	Recombinant Human C-C motif chemokine 24 (CCL24)	E.coli	N-terminal 6xHis-tagged	CSB-EP004788HU
Ccl24	Recombinant Rat Chemokine (C-C motif) ligand 24 protein (Ccl24), partial (Active)	E.Coli	Tag-Free	CSB-AP001591RA
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	N-terminal 6xHis-tagged	CSB-CF004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	in vitro E.coli expression system	C-terminal 6xHis-tagged	CSB-CF004888HUc7
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial	Mammalian cell	N-terminal 10xHis-tagged and C-terminal Myc-tagged	CSB-MP004888HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active)	Mammalian cell	C-terminal Fc-tagged	CSB-AP005061HU
CD19	Recombinant Human B-lymphocyte antigen CD19 (CD19), partial, Biotinylated	Mammalian cell	C-terminal hFc1-Avi-tagged	CSB-MP004888HU-B
CLEC4C	Recombinant Human C-type lectin domain family 4 member C (CLEC4C), partial	Yeast	N-terminal 6xHis-tagged	CSB-YP855470HU
CLEC4C	Recombinant Human C-type lectin domain family 4 member C (CLEC4C), partial (Active)	E.coli	N-terminal 6xHis-SUMO-tagged	CSB-EP855470HU
CLEC4C	Recombinant Human C-type lectin domain family 4 member C (CLEC4C), partial (Active)	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP855470HUh7
CLEC4C	Recombinant Macaca fascicularis C-type lectin domain family 4 member C (CLEC4C), partial (Active)	Mammalian cell	N-terminal 6xHis-Myc-tagged	CSB-MP4819MOV
Ifnar1	Recombinant Mesocricetus auratus?Interferon alpha/beta receptor 1 (Ifnar1), partial	Mammalian cell	C-terminal 10xHis-tagged	CSB-MP5445MRG
IL13	Recombinant Human Interleukin-13 (IL13), partial	Mammalian cell	C-terminal hFc1-Myc-tagged	CSB-MP011590HU1
IL13	Recombinant Human Interleukin-13 (IL13)	Mammalian cell	C-terminal hFc1-tagged	CSB-MP011590HU
IL13	Recombinant Rhesus Macaque Interleukin-13 protein (IL13) (Active)	E.Coli	Tag-Free	CSB-AP003181MOW
IL13	Recombinant Human Interleukin-13 (IL13), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004321HU
Il13	Recombinant Mouse Interleukin-13 (Il13), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004751MO
Il13	Recombinant Mouse Interleukin-13 (Il13), partial (Active)	Mammalian cell	C-terminal 6xHis-tagged	CSB-AP004761MO
Il13	Recombinant Mouse Interleukin-13 (Il13), partial (Active)	E.coli	Tag-Free	CSB-AP004771MO
IL13	Recombinant Human Interleukin-13 (IL13)	E.coli	N-terminal 6xHis-tagged	CSB-EP011590HU

● 抗體

CD19 Recombinant Monoclonal Antibody
CSB-RA780821A0HU

Tested Applications:
ELISA, WB, IHC, IP

ITGAV Recombinant Monoclonal Antibody
CSB-RA279866A0HU

Tested Applications:
ELISA, WB, IHC

LGALS3 Recombinant Monoclonal Antibody
CSB-RA970289A0HU

Tested Applications:
ELISA, WB, IHC, IF, IP

PDCD1 Recombinant Monoclonal Antibody
CSB-RA240597A0HU

Tested Applications:
ELISA, WB, IHC

- 重組抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA004888A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IP	CSB-RA780821A0HU
CD19	CD19 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB	CSB-RA004888MA1HU
CLEC4C	CLEC4C Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA855470MA1HU
IFNAR1	IFNAR1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA011046A0HU
IL23A	IL23A Recombinant Monoclonal Antibody	Human	ELISA, WB	CSB-RA251959A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IHC	CSB-RA548303A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA279866A0HU
ITGAV	ITGAV Recombinant Monoclonal Antibody	Human	ELISA, IF, FC	CSB-RA011877MA1HU
LGALS3	LGALS3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF, IP	CSB-RA970289A0HU
MS4A1	CD20 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A0HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA	CSB-RA015007A1HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human, Dog, Macaca fascicularis	ELISA	CSB-RA015007MA3HU
MS4A1	MS4A1 Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF	CSB-RA015007MA4HU
PDCD1	PDCD1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-RA240597A0HU
RAF1	Phospho-RAF1 (S621) Recombinant Monoclonal Antibody	Human	ELISA, WB, IF	CSB-RA019284A621phHU
RAF1	Phospho-RAF1 (S259) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF	CSB-RA019284A259phHU
RAF1	Phospho-RAF1 (S43) Recombinant Monoclonal Antibody	Human	ELISA, IF	CSB-RA019284A43phHU

- 單克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC	CSB-MA004888A0m
CD19	CD19 Monoclonal Antibody	Human	ELISA, WB, IHC, FC	CSB-MA004888A1m
CD19	CD19 Monoclonal Antibody,APC Conjugated	Human	ELISA, IF, FC	CSB-MA195220
CD19	CD19 Monoclonal Antibody,Biotin Conjugated	Human	ELISA, IF, FC	CSB-MA899608
CD19	CD19 Monoclonal Antibody,FITC Conjugated	Human	ELISA, IF, FC	CSB-MA047662
CD19	CD19 Monoclonal Antibody,PE Conjugated	Human	ELISA, IF, FC	CSB-MA036486
CD19	CD19 Monoclonal Antibody,PE-Cy5 Conjugated	Human	ELISA, IF, FC	CSB-MA281869
CD19	CD19 Monoclonal Antibody,Purified	Human	ELISA, FC	CSB-MA798261
LGALS3	LGALS3 Monoclonal Antibody	Human, Mouse	ELISA, WB, IHC	CSB-MA0128871A0m
LGALS3	LGALS3 Monoclonal Antibody	Human	ELISA, WB, IHC	CSB-MA000198
MS4A1	MS4A1 Monoclonal Antibody	Human,Mouse,Rat	ELISA, IHC	CSB-MA000204
MS4A1	MS4A1 Monoclonal Antibody	Human	ELISA, IHC	CSB-MA996413

- 多克隆抗體

Target	Product Name	Species Reactivity	Tested Applications	Code
CCL24	CCL24 Antibody	Human	ELISA, IHC	CSB-PA05909A0Rb
CCL24	CCL24 Antibody	Human	ELISA, WB	CSB-PA272302
CD19	CD19 Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA001431
CD19	Phospho-CD19 (Y531) Antibody	Human, Mouse, Monkey	ELISA, WB	CSB-PA070286
CD19	CD19 Antibody	Human	ELISA, WB	CSB-PA006159
CD19	CD19 (Ab-531) Antibody	Human, Mouse	ELISA, WB	CSB-PA253616
CD19	Phospho-CD19 (Tyr531) Antibody	Human, Mouse	ELISA, WB	CSB-PA058389
CLEC4C	CLEC4C Antibody	Human	ELISA, IHC	CSB-PA855470LA01HU
CLEC4C	CLEC4C Antibody	Human	ELISA, IHC	CSB-PA273524
CLEC4C	CLEC4C Antibody	Human	ELISA, IHC	CSB-PA640573
IFNAR1	Phospho-IFNAR1 (Y466) Antibody	Human	ELISA, WB, IHC	CSB-PA009471
IFNAR1	IFNAR1 Antibody	Human	ELISA, IHC, IF	CSB-PA009473
IFNAR1	IFNAR1 Antibody	Human	ELISA, IHC	CSB-PA107635
IFNAR1	IFNAR1 Antibody	Human	ELISA, WB	CSB-PA011046GA01HU
IFNAR1	Phospho-IFNAR1 (Ser535/Ser539) Antibody	Human	ELISA, WB	CSB-PA041971
IL13	IL13 Antibody	Human	ELISA, IHC, IF	CSB-PA011590LA01HU
IL13	IL13 Antibody	Human, Mouse, Rat	ELISA, WB, IHC	CSB-PA011590KA01HU
IL17RA	IL17RA Antibody	Human, Mouse	ELISA, WB, IF	CSB-PA12929A0Rb
IL17RA	IL17RA Antibody	Human, Mouse	ELISA, WB	CSB-PA008440
IL17RA	IL17RA Antibody	Human	ELISA, IHC	CSB-PA032717

● ELISA試劑盒

Human Transforming Growth factor β1,TGF-β1 ELISA kit
CSB-E04725h

Mouse Interleukin 13,IL-13 ELISA Kit
CSB-E04602m

Rat toll-like receptor 4 (TLR4) ELISA Kit
CSB-E15822r

Human Protein S100-A4(S100A4) ELISA kit
CSB-EL020632HU

Target	Product Name	Sample Types	Detection Range	Code
CCL24	Mouse Eotaxin 2 ELISA Kit	serum, plasma, tissue homogenates	15.6 pg/ml - 1000 pg/ml	CSB-E07278m
CCL24	Human Eotaxin 2/CCL24 ELISA Kit	serum, plasma, tissue homogenates	78.125 pg/mL-5000 pg/mL	CSB-E10360h
IL13	Mouse Interleukin 13,IL-13 ELISA Kit	serum, plasma, tissue homogenates	78 pg/ml - 5000 pg/ml	CSB-E04602m
IL13	Rat Interleukin 13,IL-13 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates	7.8 pg/mL-500 pg/mL	CSB-E07454r
IL13	Human Interleukin 13,IL-13 ELISA KIT	serum, plasma, tissue homogenates	0.39 ng/ml-25 ng/ml.	CSB-E04601h
IL13	Dog Interleukin-13(IL13) ELISA kit	serum, plasma, tissue homogenates	12.5 pg/mL-800 pg/mL	CSB-EL011590DO
IL17RA	Human Interleukin-17 receptor A(IL17RA) ELISA kit	serum, plasma, tissue homogenate	39 pg/ml-2500 pg/ml	CSB-EL011602HU
IL23A	Human Interleukin-23 subunit alpha(IL-23A) Elisa kit	serum, plasma, cell culture supernates, tissue homogenates, cell lysates	62.5 pg/mL-4000 pg/mL	CSB-E17339h
IL23A	Pig Interleukin-23 subunit alpha(IL23A) ELISA kit	serum, plasma, tissue homogenates	31.25 pg/mL-2000 pg/mL	CSB-EL011638PI
IL31RA	Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit	serum, plasma, tissue homogenates	6.25 pg/mL-400 pg/mL	CSB-EL011654HU
IL6R	Human Interleukin 6 receptor(IL-6R)ELISA Kit	serum, plasma, tissue homogenates	0.156 ng/mL-10 ng/mL	CSB-E16524h
IL6R	Rat Interleukin 6 receptor,IL-6R ELISA Kit	serum, plasma, tissue homogenates	0.625 ng/mL-40 ng/mL	CSB-E11876r
LGALS3	Human lectin-galactose binding-soluble 3,Lgals3 ELISA Kit	serum, plasma, cell culture supernates, tissue homogenates, saliva	0.625 ng/mL-40 ng/mL	CSB-E11807h
LGALS3	Mouse Galectin 3(GAL-3) ELISA Kit	serum, plasma, tissue homogenates	0.312 ng/mL-20 ng/mL	CSB-E14296m
LGALS3	Rat Galectin-3(LGALS3) ELISA kit	serum, plasma, tissue homogenates	1.56 ng/mL-100 ng/mL	CSB-EL012887RA
MS4A1	Human B-lymphocyte antigen (CD20) ELISA Kit	serum, plasma, tissue homogenates	3.12 ng/mL-200 ng/mL	CSB-E14007h
PDCD1	Human Programmed Death 1(PD-1)ELISA KIT	serum, plasma, tissue homogenates, cell lysates	15.6 pg/mL-1000 pg/mL	CSB-E13643h
PDCD1	Mouse Programmed Death 1(PD-1)ELISA Kit	serum, plasma, tissue homogenates, cell lysates	0.312 ng/mL-20 ng/mL	CSB-E13586m
S100A4	Human Protein S100-A4(S100A4) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	0.9 ng/mL-60 ng/mL	CSB-EL020632HU
S100A4	Mouse Protein S100-A4(S100A4) ELISA kit	serum, plasma, cell culture supernates, tissue homogenates	62.5 pg/mL-4000 pg/mL	CSB-EL020632MO