在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

抗Payload抗體

抗體藥物偶聯物(ADCs)是一種新型的抗癌藥物,結合了單克隆抗體和小分子毒素,具有高度靶向性和高毒素性。由于ADC 給藥后會發生payload 的解結合,導致未結合的payload 的增加和ADC 成分(即DAR 分布)的變化。因此,對偶聯的抗體和偶聯在抗體上的payload 的體內定量分析有助于評估ADC 藥效,并有助于評估payload 在靶點的暴露情況,且確定DAR 分布和平均DAR 值的變化對于提供ADC 的穩定性等整體評估至關重要。

華美CUSABIO推出適用于臨床前及臨床階段抗體藥有效研究工具——抗Payload抗體。可用于ADC藥物的血漿/血清動力學分析、藥物結合親和力的測定、DAR值分析以及ADC藥物的療效評估。

ADC 各成分與其對應分析方法

ADC 的生物分析需要一種綜合的生物分析方法,包括配體結合測定和高效液相色譜串聯質譜聯用技術(LC-MS/MS),分別用于大分子和小分子生物分析。抗payload 抗體在ADC 的免疫原性分析中至關重要,用于免疫原性分析的橋接檢測方法(Bridging LBA)。

Analyte Type Description Typical analytical platforms
Total antibody Total antibody (conjugated or unconjugated) LBA, hybrid LC-MS/MS
Total ADC Total conjugated antibody (DAR > 1)OR LBA
Total payload conjugated to antibody (DAR > 1) LBA hybrid LC-MS/MS
Unconjugated payload Payload not conjugated to antibody LC-MS/MS

(Faria et al., 2022. Doi:10.1007/978-3-030-97193-9_3)

ADC有效荷載-Anti DXD

DXD-新一代ADC最具前景的有效荷載

圖1. DXD-新一代ADC最具前景的有效荷載 [1]

應用場景

藥代動力學(PK)分析

偶聯DAR值定性分析

免疫原性分析

臨床前及臨床階段抗藥物抗體開發

產品優勢

高純度

純度經SDS-PAGE驗證大于90%

高特異性

能夠特異性識別小分子毒素

高靈敏度,高親和性

經ADC藥物結合驗證表現出顯著活性

易于檢測,節省成本

經過HRP標記的抗DXD抗體方便檢測,且無需再與二抗結合

專業技術團隊

24小時內回復您的任何售前或售后問題

產品列表

產品名稱 產品貨號 應用類型 純化方法
DXD Recombinant Monoclonal Antibody CSB-RA996977I1m ELISA Affinity-chromatography
DXD Recombinant Monoclonal Antibody CSB-RA996977I1h ELISA Affinity-chromatography
DXD Monoclonal Antibody CSB-MA996977I1m ELISA >95%, Protein G purified
DXD Monoclonal Antibody CSB-MA996977I2m ELISA >95%, Protein G purified
DXD Monoclonal Antibody, HRP conjugated CSB-MA996977I1m-B ELISA >95%, Protein G purified
DXD Monoclonal Antibody, HRP conjugated CSB-MA996977I2m-B ELISA >95%, Protein G purified
DM1 Monoclonal Antibody CSB-MA989454I0m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I0m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I1m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I2m ELISA >95%, Protein G purified
DM1&DM4 Monoclonal Antibody CSB-MA989811I3m ELISA >95%, Protein G purified
Eribulin Recombinant Monoclonal Antibody CSB-RA943989I1m ELISA Affinity-chromatography
Eribulin Monoclonal Antibody CSB-MA943989I1m ELISA >95%, Protein G purified
MMAE&MMAF Recombinant Monoclonal Antibody CSB-RA903890I1m ELISA Affinity-chromatography
MMAE&MMAF Monoclonal Antibody CSB-MA903890I1m ELISA >95%, Protein G purified
SN38 Recombinant Monoclonal Antibody CSB-RA187707I1m ELISA Affinity-chromatography
SN38 Monoclonal Antibody CSB-MA187707I1m ELISA >95%, Protein G purified

驗證數據

High purity verified by SEC-HPLC and SDS-PAGE
(Code: CSB-MA996977I2m)
SDS-PAGE驗證

The Mouse Anti-DXD Antibody (Code: CSB-MA996977I2m) has a purity of more than 90% as determined by SEC-HPLC and SDS-PAGE.

High purity verified by SEC-HPLC and SDS-PAGE
(Code: CSB-MA943989I1m)
SDS-PAGE驗證

The Mouse Anti-DXD Antibody (Code: CSB-MA943989I1m) has a purity of more than 98% as determined by SEC-HPLC and SDS-PAGE.

The Binding Activity of Disitamab vedotin (Synonyms: RC48) with Anti-MMAE antibody
(Code: CSB-MA903890I1m)
活性驗證

Activity: Measured by its binding ability in a functional ELISA. Immobilized Disitamab vedotin (Synonyms: RC48) at 2 μg/mL can bind Anti-MMAE antibody, the EC50 is 11.65 to 15.97 ng/mL.

The Binding Activity of T-DXd(DS-8201) with Anti-DXD antibody
(Code: CSB-MA996977I2m)
活性驗證

Activity: Measured by its binding ability in a functional ELISA. Immobilized T-DXd(DS-8201) at 2 μg/mL can bind Anti-DXD antibody, the activity was 4-5 times that of other companies.

定制服務

華美生物已研發多種高純度、高靈敏度,高親和力的抗Payload抗體,可用于ADC藥物的臨床前及臨床階段DAR值和PK分析,可提供定制化的抗Payload抗體,以滿足客戶的個性化需求。

參考文獻:

[1] Kumar, Seema, ed. An Introduction to Bioanalysis of Biopharmaceuticals. Vol. 57. Springer Nature, 2022.



主站蜘蛛池模板: 国产在线拍揄自揄视频网试看| 一本色道久久88亚洲精品综合| 乱中年女人伦av三区| 男人扒开女人腿桶到爽免费| 美女张开腿黄网站免费| 国产香蕉国产精品偷在线| 毛片内射久久久一区| 在线观看免费视频网站a站| 无码午夜福利免费区久久| 最新av偷拍av偷窥av网站| 午夜精品久久久久久久久久久久| 污污又黄又爽免费的网站| 伊人久久大香线蕉综合狠狠| 亚洲自偷自拍另类11p| 国产乱子伦农村xxxx| 日本一卡二卡不卡视频查询| 日韩高清亚洲日韩精品一区| 国产大陆亚洲精品国产| 高清无码爆乳潮喷在线观看| 亚洲第一无码专区天堂| 中文字幕人成无码人妻综合社区| 天堂网在线www资源| 国产精品禁18久久久夂久| 999久久久国产精品| 欧美黑人又大又粗xxxxx| 亚洲国产精品久久久久久| 免费香蕉成视频人网站| 成人综合网亚洲伊人| 国产色秀视频在线播放| 国产精品毛片久久久久久久| 曰韩少妇内射免费播放| 欧美性xxxx极品hd欧美风情| 精品综合久久久久久8888 | 久久久久久无码精品人妻a片软件| 免费无遮挡无码视频在线观看| 成人天堂婷婷青青视频在线观看 | 国产精品污www一区二区三区 | 国产精品日韩欧美一区二区三区| 好男人www社区| 国产 精品 自在 线免费| 亚洲美女视频高清在线看|