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DLL3

DLL3,即Delta樣配體3,別名Delta3、delta-like3(Drosophila)、delta-likeprotein3、Pudgy、SCDO1、SCDO1delta3。它是一種屬于Delta/Serrate/Lag-2(DSL)家族的Notch配體,主要在神經內分泌腫瘤細胞表面表達,而在正常成人組織中幾乎不表達。DLL3的作用機制涉及與Notch受體相互作用,通常作為抑制性配體,通過與Notch受體結合抑制Notch信號通路的激活,影響腫瘤細胞的增殖、分化和凋亡。DLL3在小細胞肺癌(SCLC)中的表達尤為重要,其高表達與腫瘤的發生發展密切相關,是治療SCLC的潛在藥物作用靶點。DLL3的異常表達與多種神經內分泌腫瘤的發生有關,使其成為小細胞肺癌治療的重要生物標志物和治療靶點。

熱銷產品

Recombinant Human Delta-like protein 3 (DLL3), partial (CSB-EP882142HU1)

驗證數據

CSB-EP882142HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

DLL3 Recombinant Monoclonal Antibody (CSB-RA882142A1HU)

驗證數據

CSB-RA882142A1HU

Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.

CSB-RA882142A1HU

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.

CSB-RA882142A1HU

The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.

CSB-RA882142A1HU

The purity of DLL3 was greater than 95% as determined by SEC-HPLC

Human Delta-like protein 3(DLL3) ELISA kit (CSB-EL006948HU)

驗證數據

CSB-EL006948HU 標準曲線

貨號:CSB-EL006948HU

規格:96T/48T

靈敏度:4.68 pg/mL

檢測范圍:18.75 pg/mL-1200 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

DLL3 Antibodies

DLL3 for Homo sapiens (Human)

DLL3 Proteins

DLL3 Proteins for Mus musculus (Mouse)

DLL3 Proteins for Rattus norvegicus (Rat)

DLL3 Proteins for Xenopus laevis (African clawed frog)

DLL3 Proteins for Homo sapiens (Human)

DLL3 ELISA Kit

DLL3 ELISA Kit for Homo sapiens (Human)



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