免疫檢查點(diǎn)

免疫檢查點(diǎn)是免疫激活的調(diào)控因子，主要在免疫應(yīng)答過(guò)程中調(diào)節(jié)T細(xì)胞受體（TCR）的抗原識(shí)別。它們?cè)诰S持免疫穩(wěn)態(tài)和預(yù)防自身免疫方面至關(guān)重要。根據(jù)不同的免疫激活作用，免疫檢查點(diǎn)可分為兩種類(lèi)型：共刺激免疫檢查點(diǎn)和共抑制免疫檢查點(diǎn)。共刺激免疫檢查點(diǎn)是指一系列可以進(jìn)一步刺激免疫反應(yīng)的免疫檢查點(diǎn)，如CD28，ICOS和CD137。相反，共抑制免疫檢查點(diǎn)對(duì)抑制免疫反應(yīng)的免疫檢查點(diǎn)，如PD1，CTLA-4和VISTA。在有效的抗腫瘤免疫過(guò)程中，T細(xì)胞作為核心的執(zhí)行者，首先被T細(xì)胞受體介導(dǎo)的抗原識(shí)別信號(hào)激活，同時(shí)眾多的共刺激信號(hào)和共抑制信號(hào)精細(xì)調(diào)節(jié)T細(xì)胞反應(yīng)的強(qiáng)度和質(zhì)量。在生理情況下，共刺激分子與免疫檢查點(diǎn)分子保持平衡，從而最大程度減少對(duì)于周?chē)＝M織的損傷，維持對(duì)自身組織的耐受、避免自身免疫反應(yīng)。而腫瘤細(xì)胞可以通過(guò)此機(jī)制，異常上調(diào)共抑制分子及其相關(guān)配體，抑制T細(xì)胞激活，從而逃避免疫殺傷。

PD-L1(CD274) or PD-L2(CD273) CD80 or CD86 ICOSL(CD275) CD276 / VICN1 VISTA HHLA2 Butyrophilin Family Members (e.g. Btnl2 , Skint1, MOG , CD277 ) HVEM(CD270) MHC class I or II TNFSF9(CD137L) OX40L(CD252) TNFSF7(CD70) TNFRSF5(CD40) GIRL(TNFSF18) PVR(CD155) NECTIN-2(CD112) MOX1(CD200) BCM-1(CD48) Gal-9 Adenosine IDO1 ; TDO ? PD-1(CD279) CD28(TP44) CTLA-4(CD152) ICOS(CD278) ? ? TMIGD2(CD28H) ? ? BTLA(CD272) KIR_S KIR_L TCR LAG-3(CD223) TNFRSF-9(CD137) OX40(CD134) TNFRSF7(CD27) CD40L(CD154) GITR(CD357) CD96 DNAM-1(CD226) TIGIT CD112R CD200R 2B4(CD244) TIM-3(CD366) A2aR Tryptophan

免疫檢查點(diǎn)產(chǎn)品

近幾年， CUSABIO研發(fā)團(tuán)隊(duì)致力于靶向免疫研究，為廣大科研用戶(hù)開(kāi)發(fā)了一系列免疫檢查點(diǎn)重組蛋白。這些重組免疫檢查點(diǎn)蛋白涵蓋多種物種和標(biāo)簽，秉承客戶(hù)至上的原則，所有蛋白產(chǎn)品在發(fā)貨前我們都會(huì)對(duì)其生物活性進(jìn)行再次分析和驗(yàn)證。另外，我們還提供蛋白質(zhì)定制服務(wù)，如果您找不到您需要的蛋白質(zhì)，請(qǐng)聯(lián)系我們進(jìn)行定制服務(wù)。

產(chǎn)品名稱(chēng)	貨號(hào)	規(guī)格
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active)	CSB-AP005121GU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	CSB-AP005131HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	CSB-AP005141HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 9 (TNFRSF9), partial (Active)	CSB-AP005151HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active)	CSB-AP005161HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005171HU	1mg(1mg1 or 500ug2)/500μg/50μg/10μg
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active)	CSB-AP005181HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human CD40 ligand (CD40LG), partial (Active)	CSB-AP005191HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005201HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active)	CSB-AP005211HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human CD160 antigen (CD160) (Active)	CSB-AP005221HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active)	CSB-AP005231HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)	CSB-AP005241HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)	CSB-AP005251HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Tumor necrosis factor ligand superfamily member 4 (TNFSF4), partial (Active)	CSB-AP005261HU	1mg(1mg1 or 500ug2)/500μg/50μg/10μg
Recombinant Human Tyrosine-protein phosphatase non-receptor type substrate 1 (SIRPA), partial (Active)	CSB-AP005271HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005281HU	100ug/20ug
Recombinant Human Hepatitis A virus cellular receptor 2 (HAVCR2), partial (Active)	CSB-AP005291HU	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active)	CSB-AP005301MO	1mg(1mg1 or 500ug2)/500ug/50ug/10ug
Recombinant Mouse Tumor necrosis factor receptor superfamily member 14 (Tnfrsf14), partial (Active)	CSB-AP005311MO	1mg(1mg1 or 500ug2)/500ug/50ug/10ug