在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

自身免疫疾病系列——

特發性肺纖維化

特發性肺纖維化

特發性肺纖維化(IPF)是一種慢性、進行性、致死性的間質性肺炎,以肺組織不可逆性纖維化重塑為特征,最終導致呼吸衰竭。其核心病理機制包括肺泡上皮細胞反復損傷、異常修復,驅動成纖維細胞活化為肌成纖維細胞,導致細胞外基質過度沉積,形成肺瘢痕。臨床表現為活動性呼吸困難、干咳、疲勞,常伴肺功能進行性下降,約50%患者合并間質性肺病(ILD)。IPF主要影響50歲以上人群,中位生存期僅2-5年,預后差于多數癌癥,故被稱為"不是癌癥的癌癥"。?

特發性肺纖維化(IPF)的藥物研發聚焦于纖維化、炎癥及細胞修復等核心機制,主要關注以下靶點:

轉化生長因子-β(TGF-β)通路:現有藥物尼達尼布通過抑制TGF-β下游受體(VEGFR、PDGFR、FGFR)延緩肺功能下降。百時美施貴寶的BMS-986278(Admilparant)作為溶血磷脂酸受體1(LPAR1)拮抗劑,其II期研究顯示可降低FVC年下降率54%,目前III期試驗正在進行中。

磷酸二酯酶 4B(PDE4B):勃林格殷格翰的口服抑制劑nerandomilast在III期臨床試驗 FIBRONEER-IPF中顯著減緩FVC下降,且安全性可控,已在中國提交上市申請并被納入優先審評。

結締組織生長因子(CTGF):Pliant Therapeutics的Bexotegrast(PLN-74809)通過抑制CTGF與TGF-β結合,在IIa期試驗中顯示FVC下降幅度減少,目前進入IIb/III期臨床。

目前,特發性肺纖維化新藥研發正朝著多靶點與新型機制方向突破。英矽智能借助AI發現TNIK激酶抑制劑INS018_055,臨床前展現優于尼達尼布的抗纖維化效果,且與吡非尼酮聯用增效;北京生命科學研究所鎖定AREG蛋白為關鍵靶點,其抑制劑已進入一期臨床。細胞療法領域,上海交通大學的自體基底干細胞移植、吉美瑞生的REGEND001氣道基底層干細胞療法均在臨床試驗中取得肺功能改善等積極成果。此外,韓國研究證實依折麥布可抑制成纖維細胞分化,中國學者發現GOLM1-KLF4-NEAT1信號通路具備潛在價值,為IPF治療帶來新希望。

特發性肺纖維化藥物靶點相關產品推薦

● 靶點蛋白

CSB-MP5112MOW Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Rhesus macaque CTGF at 1 μg/ml can bind Anti-CTGF recombinant antibody (CSB-RA006147MA2HU). The EC50 is 0.6886-0.7825 ng/mL.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m,antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL.

CSB-MP006254HU(F1) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CXCR4 at 10 μg/ml can bind Anti-CXCR4 recombinant antibody (CSB-RA006254MA01HU), the EC50 is 101.7-253.6 ng/mL.

CSB-MP723415HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD73 at 2 μg/ml can bind Anti- CD73 Rabbit Monoclonal Antibody(CSB-RA978310A0HU), the EC50 is 3.212-4.525 ng/ml.

Target Product Name Source Tag Info Code
CCL2 Recombinant Human C-C motif chemokine 2 (CCL2) E.coli N-terminal GST-tagged CSB-EP004783HU
CCL2 Recombinant Human C-C motif chemokine 2 (CCL2) E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP004783HUb1
CCL2 Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial E.coli N-terminal 6xHis-tagged CSB-EP004783MO
CCN2 Recombinant Human CCN family member 2 (CCN2) E.coli C-terminal 6xHis-tagged CSB-EP006147HU
CCN2 Recombinant Human CCN family member 2 (CCN2), partial E.coli N-terminal 6xHis-tagged CSB-EP006147HU1
Ccn2 Recombinant Mouse CCN family member 2 (Ccn2), partial E.coli N-terminal 10xHis-SUMO-tagged CSB-EP006147MO
Ccn2 Recombinant Mouse CCN family member 2 (Ccn2), partial E.coli N-terminal GST-tagged CSB-EP006147MOe0
CCN2 Recombinant Macaca mulatta CCN family member 2 (CCN2) (Active) Mammalian cell C-terminal 10xHis-tagged CSB-MP5112MOW
Ccn4 Recombinant Rat CCN family member 4 (Ccn4), Biotinylated E.coli N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged CSB-EP857523RA-B
CCR7 Recombinant Human C-C chemokine receptor type 7 (CCR7), partial E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP004846HU1
CCR7 Recombinant Human C-C chemokine receptor type 7 (CCR7) in vitro E.coli expression system N-terminal 6xHis-tagged CSB-CF004846HUa0
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP878942HU2
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) Mammalian cell C-terminal hFc1-tagged CSB-MP878942HU1
CD274 Recombinant Dog CD274 molecule (CD274), partial Mammalian cell C-terminal 10xHis-tagged CSB-MP5015DO1
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial ( (K136A)) E.coli N-terminal 6xHis-tagged CSB-EP878942HU1(M)
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274) (K136A), partial Yeast C-terminal 6xHis-tagged CSB-YP878942HU1(M)c7
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial Mammalian cell C-terminal 10xHis-tagged CSB-MP878942HU1d7
Cldn1 Recombinant Rat Claudin-1 (Cldn1), partial E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP005490RA1
CLDN1 Recombinant Human Claudin-1 (CLDN1) in vitro E.coli expression system N-terminal 10xHis-tagged CSB-CF005490HU
CLDN1 Recombinant Human Claudin-1 (CLDN1)-VLPs Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions) CSB-MP005490HU

● 抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Tested Applications:
ELISA, IHC, FC

CD38 Recombinant Monoclonal Antibody
CSB-RA796695A0HU
CSB-RA796695A0HU WB

Tested Applications:
ELISA, WB, IHC

ITGAL Recombinant Monoclonal Antibody
CSB-RA787996A0HU
CSB-RA787996A0HU IF

Tested Applications:
ELISA, WB, IF

PCSK9 Recombinant Monoclonal Antibody
CSB-RA259644A0HU
CSB-RA259644A0HU IHC

Tested Applications:
ELISA, WB, IHC

- 重組抗體

Target Product Name Species Reactivity Tested Applications Code
CD274 CD274 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA977797A0HU
CD274 CD274 Recombinant Monoclonal Antibody Human ELISA, IHC, FC CSB-RA878942MA1HU
CD38 CD38 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA796695A0HU
CD40 CD40 Recombinant Monoclonal Antibody Human ELISA, IF, FC CSB-RA004936MA1HU
GCGR GCGR Recombinant Monoclonal Antibody Human ELISA CSB-RA009316A1HU
IL17A IL17A Recombinant Monoclonal Antibody Human ELISA CSB-RA624104MA1HU
IL23A IL23A Recombinant Monoclonal Antibody Human ELISA, WB CSB-RA251959A0HU
IL6 IL6 Recombinant Monoclonal Antibody Human ELISA CSB-RA011664MA1HU
ITGAL ITGAL Recombinant Monoclonal Antibody Human ELISA, WB, IF CSB-RA787996A0HU
MS4A1 CD20 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A0HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A1HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human, Dog, Macaca fascicularis ELISA CSB-RA015007MA3HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA, IHC, IF CSB-RA015007MA4HU
PCSK9 PCSK9 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA259644A0HU
SELPLG SELPLG Recombinant Monoclonal Antibody Human ELISA, IHC CSB-RA567010A0HU

- 單克隆抗體

Target Product Name Species Reactivity Tested Applications Code
CD2 CD2 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000227
CD2 CD2 Monoclonal Antibody,FITC Conjugated Human ELISA, IF, FC CSB-MA785710
CD38 CD38 Monoclonal Antibody Human ELISA, IHC CSB-MA785760
IL1B IL1B Monoclonal Antibody Human ELISA CSB-MA065741A0m
IL1B IL1B Monoclonal Antibody Human ELISA, WB, IHC, ICC CSB-MA010884
IL6 IL6 Monoclonal Antibody Human ELISA, WB, IHC CSB-MA067571A0m
ITGAL ITGAL Monoclonal Antibody,FITC Conjugated Human ELISA, IF, FC CSB-MA120024
ITGAL ITGAL Monoclonal Antibody,PE Conjugated Human ELISA, IF, FC CSB-MA897229
MS4A1 MS4A1 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000204
MS4A1 MS4A1 Monoclonal Antibody Human ELISA, IHC CSB-MA996413
TNF TNF Monoclonal Antibody Bovine ELISA CSB-MA084771A0m
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080271
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080272

- 多克隆抗體

Target Product Name Species Reactivity Tested Applications Code
CD2 CD2 Antibody Human ELISA, IHC, IF CSB-PA004894LA01HU
CD2 CD2 Antibody Human ELISA, WB CSB-PA005194
CD2 CD2 Antibody Human ELISA, WB CSB-PA004894GA01HU
CD274 CD274 Antibody Human ELISA, IHC CSB-PA878942ESR1HU
CD274 CD274 Antibody Human, Mouse, Rat ELISA, WB, IHC CSB-PA004911GA01HU
CD28 CD28 Antibody Human ELISA, WB CSB-PA005199
CD28 Phospho-CD28 (Y218) Antibody Human, Mouse ELISA, WB CSB-PA070302
CD38 CD38 Antibody Human ELISA, IHC CSB-PA004929ESR1HU
CD38 CD38 Antibody Human ELISA, WB CSB-PA005628
CD38 CD38 Antibody Human ELISA, WB CSB-PA134528
CD38 CD38 Antibody Human ELISA, WB, IHC CSB-PA926996
CD3D CD3D Antibody Human ELISA, IHC CSB-PA004930ESR1HU
CD3D CD3D Antibody Human ELISA, WB CSB-PA001452
CD3D CD3D Antibody Human ELISA, WB CSB-PA005826
CD3D CD3D Antibody Human, Mouse, Rat ELISA, WB, IF CSB-PA004930GA01HU
CD40 CD40 Antibody Human, Mouse ELISA, WB, IF CSB-PA004936LA01HU
CD40 CD40 Antibody Human, Mouse, Monkey ELISA, WB, IHC CSB-PA001455
CD40 Phospho-CD40 (T254) Antibody Human, Mouse ELISA, WB CSB-PA080031
CD40 CD40 Antibody Human ELISA, WB CSB-PA004936GA01HU
CD40 CD40 Antibody Human, Mouse ELISA, IHC CSB-PA215588

● ELISA試劑盒

Target Product Name Sample Types Detection Range Code
CCL2 Human high sensitivity C-C motif chemokine 2 (CCL2) ELISA kit serum, plasma, tissue homogenates 6.25 pg/mL-400 pg/mL CSB-EQ004783HU
TGFB1 Rat Transforming Growth Factor β1(TGF-β1) ELISA kit serum, plasma, cell culture supernates, tissue homogenates 6.25 pg/mL-400 pg/mL CSB-E04727r
TGFB1 Human Transforming Growth factor β1,TGF-β1 ELISA kit serum, plasma, cell culture supernates 0.78 ng/mL-50 ng/mL CSB-E04725h
TGFB1 Mouse Transforming Growth factor β1,TGF-β1 ELISA kit serum, plasma, cell culture supernates 0.78 ng/mL-50 ng/mL CSB-E04726m
CCL2 Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit serum, plasma, tissue homogenates 78 pg/mL-5000 pg/mL CSB-E07430m
CCL2 Rat monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit serum, plasma, tissue homogenates 31.25 pg/mL-2000 pg/mL CSB-E07429r
IL13 Mouse Interleukin 13,IL-13 ELISA Kit serum, plasma, tissue homogenates 78 pg/ml - 5000 pg/ml CSB-E04602m
CCL2 Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis 6.25 pg/ml-400 pg/ml. CSB-E04655h
CD274 Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit serum, plasma, tissue homogenates, cell lysates 15.6 pg/mL-1000 pg/mL CSB-E13644h
IL13 Rat Interleukin 13,IL-13 ELISA KIT serum, plasma, cell culture supernates, tissue homogenates 7.8 pg/mL-500 pg/mL CSB-E07454r
TGFB1 Chicken Transforming Growth factor β1,TGF-β1 ELISA kit serum, plasma, tissue homogenates 0.312 ng/mL-20 ng/mL CSB-E09875Ch
IL13 Human Interleukin 13,IL-13 ELISA KIT serum, plasma, tissue homogenates 0.39 ng/ml-25 ng/ml. CSB-E04601h
CLDN1 Human Claudin-1(CLDN1) ELISA kit serum, plasma, tissue homogenates, cell lysates 15.6 pg/mL-1000 pg/mL CSB-EL005490HU
TGFB1 Pig transforming growth factor β1(TGF-β1)ELISA Kit serum, plasma 0.78 ng/mL-50 ng/mL CSB-E06843p
IL11 Mouse Interleukin 11,IL-11 ELISA KIT serum, plasma, tissue homogenates 78 pg/ml - 5000 pg/ml CSB-E04597m
CCL2 Rabbit monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit serum, plasma, tissue homogenates 23.5 pg/mL-1500 pg/mL CSB-E06921Rb
ENO1 Human Alpha-enolase (ENO1/ENO1L1/MBPB1/MPB1) ELISA kit serum, tissue homogenates, plasma 0.312 ng/mL-20 ng/mL CSB-E17177h
CXCR4 Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit serum, plasma, cell culture supernates, tissue homogenates 0.156 ng/mL-10 ng/mL CSB-E12703r
CXCR4 Human CXC-chemokine receptor 4(CXCR4)ELISA Kit serum, plasma, tissue homogenates 15.6 pg/mL-1000 pg/mL CSB-E12825h
CCL2 Pig monocyte chemotactic protein 1,MCP1 ELISA Kit serum, plasma 31.25 pg/mL-2000 pg/mL CSB-E13178p


主站蜘蛛池模板: 中文字幕人妻少妇引诱隔壁| 国产成人精品a视频免费福利| 天天摸夜夜添狠狠添婷婷| 性色av无码不卡中文字幕| 国产精品久久久av久久久| 日本丰满护士bbw| 国产午夜无码片在线观看影视| 国产传媒精品1区2区3区| 国产日产韩国精品视频| 欧美刺激性大交| 国产精品无码mv在线观看| 亚洲中文字幕日产乱码在线| 久久天天躁夜夜躁狠狠躁 | av无码国产精品色午夜| 国产国拍精品av在线观看按摩| 最近中文字幕在线中文视频| 国产精品高清视亚洲中文| 天堂久久天堂av色综合| 免费无码又爽又刺激软件下载直播| 18禁黄无遮挡网站| 午夜私人成年影院| 国产一卡2卡3卡4卡精品| 2020国产在线拍揄自揄视频| 国产女主播喷水视频在线观看| 国产一区二区野外| 亚洲欧洲精品无码av| 三级特黄60分钟在线播放| 日本三级韩国三级欧美三级| 国产在线欧美日韩精品一区| 在线观看无码av网址| 日韩av无码精品人妻系列| 国产精品一区波多野结衣| www一区二区乱码www| ā片在线观看免费观看| 精品人妻系列无码人妻免费视频| 国产高清在线精品一区小说| 无码国模国产在线观看| 99国产精品自在自在久久| 果冻传媒mv免费播放在线观看| 新香蕉少妇视频网站| 欧美xxxx精品另类|