在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

自身免疫疾病系列——

間質性肺疾病

間質性肺疾病

間質性肺疾?。↖LD)是一組以肺實質炎癥和進行性纖維化為特征的異質性疾病,核心病理機制為肺泡上皮反復損傷后異常修復,導致成纖維細胞活化、細胞外基質(如膠原)過度沉積,形成不可逆的肺瘢痕。

ILD包含200余種亞型,其中特發性肺纖維化(IPF)最常見且預后最差,主要影響50歲以上人群,全球患病率約6.3/10萬,5年生存率僅20%-25%,低于多數癌癥。臨床表現為進行性呼吸困難、干咳、爆裂音,晚期可繼發肺動脈高壓和呼吸衰竭。

近年ILD藥物研發聚焦抗纖維化新靶點與疾病修飾療法,最新進展如下:

► PDE4B抑制劑:

  • 那米司特(Nerandomilast):勃林格殷格翰的口服選擇性PDE4B抑制劑,通過升高細胞內cAMP抑制NF-κB/NFAT信號,減少促炎因子釋放。2025年2月其III期研究FIBRONEER?-ILD達到主要終點,成為十年來首個成功的III期新藥,已向中美監管機構遞交IPF和進展性肺纖維化(PPF)適應癥申請。
  • SYH2059:石藥集團的高選擇性PDE4B抑制劑,臨床前活性優于同類藥物,2025年獲中美臨床試驗批準,靶向ILD。

► 細胞療法:

  • NCR101注射液:全球首款iPSC來源的基因修飾間充質樣細胞(iMSC)療法,通過基因工程增強抗炎與組織修復功能。2025年3月獲中國臨床許可,治療ILD,突破傳統MSC的異質性與產量限制。

► 急性加重期治療優化:

  • 尼達尼布:系統評價顯示,在ILD急性加重期(AE-ILD)啟動治療可顯著降低住院死亡率并縮短住院時間,可能與多重酪氨酸激酶抑制(PDGFR/VEGFR/FGFR)阻斷纖維化信號相關。

► 其他新興靶點:

  • WISP1抗體(MTX-463):禮來/Mediar開發,中和WNT通路關鍵蛋白WISP1,阻斷成纖維細胞活化,II期試驗進行中。
  • JAK抑制劑(如魯索替尼):靶向JAK-STAT通路調控巨噬細胞極化,臨床前使膠原沉積減少50%,探索老藥新用。

間質性肺疾病(ILD)藥物靶點相關產品推薦

● 靶點蛋白

CSB-MP002831HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC50 is 21.95-33.12 ng/ml.

CSB-MP5112MOW Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Rhesus macaque CTGF at 1 μg/ml can bind Anti-CTGF recombinant antibody (CSB-RA006147MA2HU). The EC50 is 0.6886-0.7825 ng/mL.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m,antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL.

CSB-MP006043HU1 Activity Verified

The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.

CSB-MP6408HU Activity Verified

The ED50 as determined by the dose-dependent stimulation of the proliferation of TF-1 cells is 2.045-6.215 ng/mL

CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL.

CSB-MP723415HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD73 at 2 μg/ml can bind Anti- CD73 Rabbit Monoclonal Antibody (CSB-RA978310A0HU), the EC50 is 3.212-4.525 ng/ml.

CSB-MP025141HUh7 Activity Verified

Measured by its binding ability in a functional ELISA.Immobilized Human TSLP at 2 μg/ml can bind Anti-TSLP recombinant antibody(CSB-RA025141MA2HU). The EC50 is 5.487-6.214 ng/mL.

Target Product Name Source Tag Info Code
B2M Recombinant Sheep Beta-2-microglobulin (B2M) E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP002486SH
B2M Recombinant Pig Beta-2-microglobulin (B2M) E.coli Tag-free CSB-EP4852PI
B2m Recombinant Mesocricetus auratus Beta-2-microglobulin (B2m) E.coli Tag-Free CSB-EP4853MRG
BSG Recombinant Human Basigin (BSG), partial (Active) Mammalian cell C-terminal hFc-tagged CSB-MP002831HU1
C5 Recombinant Human Complement C5 (C5), partial E.coli N-terminal 6xHis-SUMO-tagged CSB-EP003995HU
C5 Recombinant Rat Complement C5 (C5) E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP003995RA
C5 Recombinant Human Complement C5 (C5), partial Mammalian cell N-terminal 6xHis-Myc-tagged CSB-MP003995HU
C5 Recombinant Pig Complement C5a anaphylatoxin (C5) Yeast N-terminal 6xHis-tagged CSB-YP003995PI
CCL2 Recombinant Human C-C motif chemokine 2 protein (CCL2) E.coli N-terminal GST-tagged CSB-EP004783HU
CCL2 Recombinant Human C-C motif chemokine 2 (CCL2) E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP004783HUb1
CCL2 Recombinant Mouse C-C motif chemokine 2 (Ccl2), partial E.coli N-terminal 6xHis-tagged CSB-EP004783MO
CCN2 Recombinant Human CCN family member 2 (CCN2) E.coli C-terminal 6xHis-tagged CSB-EP006147HU
CCN2 Recombinant Human CCN family member 2 (CCN2), partial E.coli N-terminal 6xHis-tagged CSB-EP006147HU1
Ccn2 Recombinant Mouse CCN family member 2 (Ccn2), partial E.coli N-terminal 10xHis-SUMO-tagged CSB-EP006147MO
Ccn2 Recombinant Mouse CCN family member 2 (Ccn2), partial E.coli N-terminal GST-tagged CSB-EP006147MOe0
CCN2 Recombinant Macaca mulatta CCN family member 2 (CCN2) Mammalian cell C-terminal 10xHis-tagged CSB-MP5112MOW
Ccn4 Recombinant Rat CCN family member 4 (Ccn4), Biotinylated E.coli N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged CSB-EP857523RA-B
CCR7 Recombinant Human C-C chemokine receptor type 7 (CCR7), partial E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP004846HU1
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial E.coli N-terminal 10xHis-tagged and C-terminal Myc-tagged CSB-EP878942HU2
CD274 Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) Mammalian cell C-terminal hFc-tagged CSB-MP878942HU1

● 抗體

CD274 Recombinant Monoclonal Antibody
CSB-RA977797A0HU
CSB-RA977797A0HU WB

Tested Applications:
ELISA, WB, IHC

ITGAV Recombinant Monoclonal Antibody
CSB-RA279866A0HU
CSB-RA279866A0HU IHC

Tested Applications:
ELISA, WB, IHC

LOXL2 Recombinant Monoclonal Antibody
CSB-RA907007A0HU
CSB-RA907007A0HU Fc

Tested Applications:
ELISA, WB, IHC, IF, FC

NT5E Recombinant Monoclonal Antibody
CSB-RA978310A0HU
CSB-RA978310A0HU IHC

Tested Applications:
ELISA, IHC

- 重組抗體

Target Product Name Species Reactivity Tested Applications Code
CD274 CD274 Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA977797A0HU
CD274 CD274 Recombinant Monoclonal Antibody Human ELISA, IHC, FC CSB-RA878942MA1HU
CXCR4 CXCR4 Recombinant Monoclonal Antibody Human ELISA, IF CSB-RA569311A0HU
CXCR4 CXCR4 Recombinant Monoclonal Antibody Human ELISA CSB-RA006254MA01HU
IL6 IL6 Recombinant Monoclonal Antibody Human ELISA CSB-RA011664MA1HU
ITGAV ITGAV Recombinant Monoclonal Antibody Human ELISA, IHC CSB-RA548303A0HU
ITGAV ITGAV Recombinant Monoclonal Antibody Human ELISA, WB, IHC CSB-RA279866A0HU
ITGAV ITGAV Recombinant Monoclonal Antibody Human ELISA, IF, FC CSB-RA011877MA1HU
LOXL2 LOXL2 Recombinant Monoclonal Antibody Human, Mouse, Rat ELISA, WB, IHC, IF, FC CSB-RA907007A0HU
MS4A1 CD20 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A0HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA CSB-RA015007A1HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human, Dog, Macaca fascicularis ELISA CSB-RA015007MA3HU
MS4A1 MS4A1 Recombinant Monoclonal Antibody Human ELISA, IHC, IF CSB-RA015007MA4HU
NT5E NT5E Recombinant Monoclonal Antibody Human ELISA, IHC CSB-RA978310A0HU
TSLP TSLP Recombinant Monoclonal Antibody Human ELISA CSB-RA025141A1HU

- 單克隆抗體

Target Product Name Species Reactivity Tested Applications Code
CCL2 CCL2 Monoclonal Antibody Human ELISA, IHC CSB-MA058641A0m
ENG ENG Monoclonal Antibody Human ELISA, IHC CSB-MA294403
ENO1 ENO1 Monoclonal Antibody Human, Mouse, Rat, Rabbit ELISA, WB, IHC, IF, FC, IP CSB-MA007670A0m
ENO1 ENO1 Monoclonal Antibody Human, Mouse, Rat, Rabbit ELISA, WB, IF, FC, IP CSB-MA007670A1m
IL6 IL6 Monoclonal Antibody Human ELISA, WB, IHC CSB-MA067571A0m
MS4A1 MS4A1 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000204
MS4A1 MS4A1 Monoclonal Antibody Human ELISA, IHC CSB-MA996413
TNF TNF Monoclonal Antibody Bovine ELISA CSB-MA084771A0m
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080271
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080272

- 多克隆抗體

Target Product Name Species Reactivity Tested Applications Code
B2M B2M Monoclonal Antibody Human ELISA, IHC CSB-MA057861A0m
CCL2 CCL2 Monoclonal Antibody Human ELISA, IHC CSB-MA058641A0m
ENG ENG Monoclonal Antibody Human ELISA, IHC CSB-MA294403
ENO1 ENO1 Monoclonal Antibody Human, Mouse, Rat, Rabbit ELISA, WB, IHC, IF, FC, IP CSB-MA007670A0m
ENO1 ENO1 Monoclonal Antibody Human, Mouse, Rat, Rabbit ELISA, WB, IF, FC, IP CSB-MA007670A1m
IL6 IL6 Monoclonal Antibody Human ELISA, WB, IHC CSB-MA067571A0m
MS4A1 MS4A1 Monoclonal Antibody Human,Mouse,Rat ELISA, IHC CSB-MA000204
MS4A1 MS4A1 Monoclonal Antibody Human ELISA, IHC CSB-MA996413
TNF TNF Monoclonal Antibody Bovine ELISA CSB-MA084771A0m
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080271
TNF TNF Monoclonal Antibody Human,Mouse,Rat ELISA, WB, IHC CSB-MA080272
AREG AREG Antibody Human ELISA, IHC, IF CSB-PA11339A0Rb
AREG AREG Antibody Human ELISA, WB CSB-PA006314
AREG AREG Antibody Human ELISA, WB, IHC, IF CSB-PA001986GA01HU
AREG AREG Antibody Human ELISA, WB CSB-PA441346
AREG AREG Antibody Human ELISA, WB CSB-PA694774
B2M B2M Antibody Human, Mouse ELISA, WB, IHC CSB-PA002486YA01HU
B2M B2M Antibody Human, Mouse ELISA, WB CSB-PA05786A0Rb
B2m B2m Antibody Mouse ELISA, WB, IHC CSB-PA002486LA01MO
B2M B2M Antibody Human, Mouse, Rat ELISA, FC, IF, IHC, WB CSB-PA002486GA01HU

● ELISA試劑盒

Target Product Name Sample Types Detection Range Code
CSF2 Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit serum, plasma, cell culture supernates, tissue homogenates 15.6 pg/mL-1000 pg/mL CSB-E04568h
IL6 Human Interleukin 6,IL-6 ELISA KIT serum, plasma, cell culture supernates, tissue homogenates, urine 7.8 pg/mL-500 pg/mL CSB-E04638h
CCL2 Human monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit serum, plasma, urine, saliva, cerebrospinal fluid (CSF), ascitic fluid, cell culture supernates, tis 6.25 pg/ml-400 pg/ml. CSB-E04655h
CSF1 Mouse Macrophage Colony-Stimulating Factor,M-CSF ELISA kit serum, plasma, tissue homogenates 7.81 pg/mL-500 pg/mL CSB-E04659m
TGFB1 Human Transforming Growth factor β1,TGF-β1 ELISA kit serum, plasma, cell culture supernates 0.78 ng/mL-50 ng/mL CSB-E04725h
TGFB1 Dog Transforming growth factor β1,TGF-β1 ELISA Kit serum, plasma 0.781 ng/ml - 50 ng/ml CSB-E04796c
B2M Human β2-microglobulin,BMG/β2-MG ELISA Kit serum, urine 0.039 μg/mL-10 μg/mL CSB-E04883h
CCL2 Mouse monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP-1/MCAF ELISA kit serum, plasma, tissue homogenates 78 pg/mL-5000 pg/mL CSB-E07430m
ENG Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit serum, plasma, tissue homogenates 6.25 ng/mL-400 ng/mL CSB-E09921m
CSF1R Human Macrophage Colony-Stimulating Factor Receptor,M-CSFR ELISA Kit serum, plasma, tissue homogenates 0.156 ng/mL-10 ng/mL CSB-E10012h
ENG Human Soluble Endoglin,sENG/sCD105 ELISA Kit serum, plasma, tissue homogenates 0.156 ng/mL-10 ng/mL CSB-E10030h
CCL2 Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit serum, plasma, tissue homogenates 0.125 ng/mL-8 ng/mL CSB-E15747c
IL6R Human Interleukin 6 receptor(IL-6R)ELISA Kit serum, plasma, tissue homogenates 0.156 ng/mL-10 ng/mL CSB-E16524h
TNF Pig Tumor necrosis factor (TNF/TNFA/TNFSF2) ELISA kit serum, plasma, cell culture supernates, tissue homogenates 0.047 ng/mL-3 ng/mL CSB-E16980p
IL6 Mouse Interleukin 6,IL-6 ELISA Kit serum, plasma, tissue homogenates, cell culture supernates 3.9 pg/ml-250 pg/ml CSB-E04639m-IS
TNF Mouse Tumor necrosis factor α,TNF-α ELISA KIT q 62.5 pg/mL-4000 pg/mL CSB-E04741m(1)
TNF Mouse Tumor necrosis factor α,TNF-α ELISA Kit serum, plasma, tissue homogenates, cell culture supernates 7.8 pg/ml-500 pg/ml CSB-E04741m-IS
AREG Human keratinocyte autocrine factor/Amphiregulin,KAF/AR ELISA Kit serum, plasma 4.7 pg/mL-300 pg/mL CSB-E04496h
CSF2 Mouse Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit serum, plasma, tissue homogenates 15.6 pg/mL-1000 pg/mL CSB-E04569m
CSF2 Rat Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit serum, plasma, tissue homogenates 15.6 pg/ml - 1000 pg/ml CSB-E04570r


主站蜘蛛池模板: 久久99av无色码人妻蜜| 中文字幕一区日韩精品| 色综合久久无码中文字幕| 亚洲精品乱码久久久久蜜桃| 亚洲人成电影网站色迅雷| 娇小萝被两个黑人用半米长| 无码国产精品一区二区免费16| 麻豆国产成人av在线播放欲色| 欧美506070老妇乱子伦| 日本人妻丰满熟妇久久久久久| 亚洲国产人在线播放首页| 在线毛片片免费观看| 乱中年女人伦av| 欧美性猛交xxxx免费看蜜桃| 少妇激情一区二区三区视频| 亚洲精品无码aⅴ中文字幕蜜桃| 蜜桃av久久久一区二区三区麻豆| 成年轻人电影www无码| 性高湖久久久久久久久aaaaa| 亚洲欧美成人精品香蕉网| 国内精品久久久久影院网站| 久久久久蜜桃精品成人片| 欧美性猛交xxxx乱大交极品| 鲁丝一区二区三区免费| 国产人妻一区二区三区四区五区六 | 亚洲国产精品国语在线| 无码国产色欲xxxx视频| 色悠久久久久久久综合网| 亚洲国产欧美日韩在线人成| 国产精品福利2020久久| 久久激情日本亚洲欧洲国产中文| 国产未发育呦交视频| 免费午夜爽爽爽www视频十八禁| 青青草97国产精品免费观看| 丰满熟妇被猛烈进入高清片| 久久99精品国产麻豆婷婷洗澡| 国产精品久久自在自线不| 中文人妻无码一区二区三区在线 | 久久好在线视频| 亚洲一区二区三区高清在线看| 日本理论片午午伦夜理片2021 |