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Dog Monocyte Chemotactic Protein 1/Monocyte Chemotactic And Activating Factor(MCP-1/MCAF) ELISA kit

  • 中文名稱:
    犬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒
  • 貨號:
    CSB-E15747c
  • 規格:
    96T/48T
  • 價格:
    ¥4200/¥3000
  • 其他:

產品詳情

  • 產品描述:
    犬單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯免疫試劑盒(CSB-E15747c)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的CCL2含量。CCL2是一種趨化因子,在多種生理和病理過程中發揮重要作用。它可招募單核細胞、淋巴細胞等至炎癥部位。研究發現其與腫瘤進展、炎癥性疾病等密切相關,機制涉及促進腫瘤細胞增殖、轉移以及放大炎癥反應等。試劑盒檢測范圍為0.125 ng/mL-8 ng/mL,靈敏度為0.147 ng/mL。科研人員可將其應用于犬類疾病模型的炎癥機制研究、免疫相關藥物研發的療效評估,或結合其他指標探索心血管疾病、代謝綜合征等病理過程中趨化因子網絡的調控規律。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    CCL2 ELISA Kit; MCP1 ELISA Kit; SCYA2C-C motif chemokine 2 ELISA Kit; Monocyte chemoattractant protein 1 ELISA Kit; Monocyte chemotactic protein 1 ELISA Kit; MCP-1 ELISA Kit; Small-inducible cytokine A2 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Canis lupus familiaris (Dog) (Canis familiaris)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    0.125 ng/mL-8 ng/mL
  • 靈敏度:
    0.147 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展:
        CCL2,全稱為趨化因子C-C motif ligand 2,也稱為單核細胞趨化蛋白1(MCP-1)。它是一種細胞因子,參與了許多生理和病理過程,如炎癥、腫瘤、自身免疫性疾病等。CCL2主要由單核細胞、巨噬細胞和內皮細胞分泌,在炎癥和組織損傷時被激活。CCL2可引導單核細胞、記憶性T細胞和樹突狀細胞等進入炎癥和損傷組織,促進炎癥反應和組織修復。CCL2也參與了腫瘤的發生和發展,可以引起腫瘤相關的炎癥反應,增加腫瘤細胞的浸潤和轉移。
     
  • 功能:
    Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. May play a significant role in monocyte trafficking into the reperfused myocardium.
  • 基因功能參考文獻:
    1. Analysis of ROC suggests the use of serum levels of MCP-1 and IL-7 as predictors of the occurrence of complications with an AUC of 0.906 and 0.896 respectively and linear combinations of MCP-1, KC-Like, IL-7 and GM-CSF with values up to AUC = 0.983 PMID: 29304171
    2. data suggest that CCL2 acts as a PMNs chemotactic factor as well as CXCL8, and both CCL2 and CXCL8 facilitate the infiltration of PMNs into the joints of idiopathic polyarthritis PMID: 27863550
    3. The study findings suggest that both CCL2 and CXCL8 are involved in the pathogenesis of canine idiopathic pulmonary fibrosis. PMID: 26231926
    4. CCL2 concentrations might be related to the breed predisposition of the West Highland white terrier for canine idiopathic pulmonary fibrosis. PMID: 26267090
    5. MCP-1 might be helpful as a screening blood test marker for detection of neoplasia and inflammation in dogs. PMID: 22986270
    6. Adipose tissue-derived mesenchymal stem cells expressed the mRNA of transforming growth factor beta (TGF-beta), IL-6, IL-8, CCL2, CCL5, VEGF,HGF, tissue inhibitor metalloproteinase-1/2, and cyclooxygenase-2 but not that of IL-10. PMID: 18717642

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine beta (chemokine CC) family
  • 組織特異性:
    Endothelium of small veins and intrafascicular veins, and infiltrating leukocytes.
  • 數據庫鏈接:


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