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BSG

Basigin(BSG),又稱CD147,是一種高度糖基化的、分子量為50~60kD的跨膜糖蛋白,屬于免疫球蛋白超家族(IgSF)成員。人BASIGIN由269個(gè)氨基酸組成,可分為胞外區(qū)、跨膜區(qū)及胞內(nèi)區(qū)。BSG可通過刺激腫瘤細(xì)胞自身及其周圍的成纖維細(xì)胞,分泌多種基質(zhì)金屬蛋白酶(extracellular matrix metalloproteinase,MMP),包括MMP-1、MMP-2、MMP-3、MMP-11以及MT1-MMP和MT2-MMP等,從而加快腫瘤周圍基質(zhì)的降解,促進(jìn)了腫瘤的轉(zhuǎn)移。已證實(shí)BASIGIN在許多類型的人實(shí)體瘤,如肺癌、肝癌、宮頸癌、結(jié)腸癌、乳腺癌、卵巢癌、食管癌或胃癌中過度表達(dá)。既往研究表明,Basigin分子是腫瘤發(fā)展過程重要的功能性膜蛋白,參與多種與癌癥有關(guān)的現(xiàn)象。目前,Basigin已被作為一種新的腫瘤標(biāo)志物和治療靶點(diǎn)。

Recombinant Human BSG 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC50 is 21.95-33.12 ng/ml.


BSG Antibodies

BSG for Homo sapiens (Human)

BSG Proteins

BSG Proteins for Mus musculus (Mouse)

BSG Proteins for Gallus gallus (Chicken)

BSG Proteins for Homo sapiens (Human)

BSG Proteins for Rattus norvegicus (Rat)

BSG Proteins for Oryctolagus cuniculus (Rabbit)

BSG Proteins for Bos taurus (Bovine)

BSG Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

BSG ELISA Kit

BSG ELISA Kit for Homo sapiens (Human)