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  4. Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit

Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit

  • 中文名稱：
    人白介素-31受體α亞基(IL31RA)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL011654HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人白介素-31受體α亞基(IL31RA)酶聯(lián)免疫試劑盒（CSB-EL011654HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的IL31RA含量。IL31RA是一種重要靶點(diǎn)。它參與多種生理和病理過程，尤其在免疫調(diào)節(jié)與炎癥反應(yīng)方面。其研究機(jī)制主要聚焦于它與配體IL-31結(jié)合后激活下游信號(hào)通路，影響細(xì)胞的生物學(xué)行為，對(duì)相關(guān)疾病的發(fā)生發(fā)展意義重大，是藥物研發(fā)的潛在方向。試劑盒檢測(cè)范圍為6.25 pg/mL-400 pg/mL，本試劑盒基于高特異性配對(duì)抗體開發(fā)，操作流程標(biāo)準(zhǔn)化，適用于科研領(lǐng)域中對(duì)IL - 31信號(hào)通路的機(jī)制研究、疾病模型構(gòu)建或藥物干預(yù)效果評(píng)估，可為探索IL31RA在免疫調(diào)節(jié)、炎癥反應(yīng)或皮膚相關(guān)疾病中的功能提供定量分析工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Class I cytokine receptor ELISA Kit; CRL 3 ELISA Kit; CRL ELISA Kit; CRL3 ELISA Kit; Cytokine receptor like 3 ELISA Kit; Cytokine receptor-like 3 ELISA Kit; GLM R ELISA Kit; GLM-R ELISA Kit; GLMR ELISA Kit; Gp130 like monocyte receptor ELISA Kit; GP130 like receptor ELISA Kit; Gp130-like monocyte receptor ELISA Kit; Gp130-like receptor ELISA Kit; GPL ELISA Kit; HGLM R ELISA Kit; HGLM-R ELISA Kit; HGLMR ELISA Kit; IL 31 receptor subunit alpha ELISA Kit; IL 31R subunit alpha ELISA Kit; IL 31RA ELISA Kit; IL-31 receptor subunit alpha ELISA Kit; IL-31R subunit alpha ELISA Kit; IL-31R-alpha ELISA Kit; IL-31RA ELISA Kit; IL31 receptor subunit alpha ELISA Kit; IL31R subunit alpha ELISA Kit; IL31R_HUMAN ELISA Kit; IL31RA ELISA Kit; Interleukin 31 receptor A ELISA Kit; interleukin 31 receptor subunit alpha ELISA Kit; Interleukin-31 receptor subunit alpha ELISA Kit; MGC125346 ELISA Kit; PLCA 2 ELISA Kit; PLCA2 ELISA Kit; PRO21384 ELISA Kit; Soluble type I cytokine receptor CRL3 ELISA Kit; ZcytoR17 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IL31RA in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:5 Average % 95
    Range % 89-99
    1:10 Average % 102
    Range % 96-107
    1:20 Average % 96
    Range % 92-103
    1:40 Average % 89
    Range % 82-94
  • 回收率：
    The recovery of human IL31RA spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 86 82-91
    EDTA plasma (n=4) 97 92-102
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    400 2.943 2.875 2.909 2.819
    200 2.387 2.246 2.317 2.227
    100 1.554 1.512 1.533 1.443
    50 0.826 0.808 0.817 0.727
    25 0.467 0.455 0.461 0.371
    12.5 0.259 0.246 0.253 0.163
    6.25 0.179 0.173 0.176 0.086
    0 0.091 0.089 0.090 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
  • 基因功能參考文獻(xiàn)：
    1. The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. PMID: 28408397
    2. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
    3. detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia PMID: 24667097
    4. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
    5. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
    6. IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation PMID: 20849534
    7. The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology. PMID: 19690585
    8. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. PMID: 11877449
    9. GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor PMID: 14504285
    10. the molecular mechanisms underlying GPL-mediated signal transduction PMID: 15194700
    11. IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma PMID: 18580959
    12. ). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways.[review] PMID: 18926762

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  • 相關(guān)疾病：
    Amyloidosis, primary localized cutaneous, 2 (PLCA2)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 組織特異性：
    Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, b
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18969

    OMIM: 609510

    KEGG: hsa:133396

    STRING: 9606.ENSP00000415900

    UniGene: Hs.55378



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