S100A4
S100A4蛋白全稱為鈣結合蛋白S100A4,也被稱為轉移素或p9Ka,是一種多功能小分子蛋白。它通過與細胞內不同靶點結合,影響細胞骨架動態變化,促進細胞運動及侵襲能力,尤其在腫瘤轉移過程中扮演關鍵角色。S100A4常與乳腺癌、結直腸癌等多種惡性腫瘤的侵襲性生長和遠端擴散密切相關,其高表達常提示患者預后不良。此外,在肺纖維化、類風濕性關節炎等慢性疾病中,S100A4也被發現參與組織異常重塑和炎癥反應調控。
近年來研究發現,抑制S100A4功能可有效減緩腫瘤轉移進程。多個研究團隊正在開發針對該蛋白的小分子抑制劑和單克隆抗體,其中部分化合物已在動物模型中顯示出阻斷癌細胞遷移的效果。某些已上市藥物如二甲雙胍被發現具有間接調控S100A4表達的作用,這為老藥新用提供了潛在方向。學術界與制藥企業正通過結構生物學手段解析其三維構象,以期設計出更精準的靶向治療藥物。
熱銷產品
Recombinant Human Protein S100-A4 (S100A4) (CSB-EP020632HU)
驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
S100A4 Antibody (CSB-PA020632HA01HU)
驗證數據

Western blot
All lanes: S100A4 antibody at 2µg/ml + A549 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 12 kDa
Observed band size: 12 kDa

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA020632HA01HU diluted at 1:600 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
S100A4 Antibodies
S100A4 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA020632HD01HU | S100A4 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA020632HC01HU | S100A4 Antibody, FITC conjugated | Human | |
CSB-PA020632HB01HU | S100A4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA020632HA01HU | S100A4 Antibody | Human | ELISA, WB, IHC |
CSB-PA286071 | S100A4 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA443727 | S100A4 Antibody | Human | ELISA,IHC |
CSB-PA929601 | S100A4 Antibody | Human | ELISA,WB,IHC |
S100A4 Proteins
S100A4 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP020632HU CSB-BP020632HU CSB-MP020632HU CSB-EP020632HU-B |
Recombinant Human Protein S100-A4 (S100A4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP020632HU | Recombinant Human Protein S100-A4 (S100A4) | E.coli |
S100A4 Proteins for Bos taurus (Bovine)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP020632BO CSB-EP020632BO CSB-BP020632BO CSB-MP020632BO CSB-EP020632BO-B |
Recombinant Bovine Protein S100-A4 (S100A4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
S100A4 Proteins for Rattus norvegicus (Rat)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP020632RA CSB-BP020632RA CSB-MP020632RA CSB-EP020632RA-B |
Recombinant Rat Protein S100-A4 (S100a4) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP020632RA | Recombinant Rat Protein S100-A4 (S100a4) | E.coli |
S100A4 Proteins for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP020632MO CSB-EP020632MO CSB-BP020632MO CSB-MP020632MO CSB-EP020632MO-B |
Recombinant Mouse Protein S100-A4 (S100a4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
S100A4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP883309DO CSB-EP883309DO CSB-BP883309DO CSB-MP883309DO CSB-EP883309DO-B |
Recombinant Dog Protein S100-A4 (S100A4) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
S100A4 ELISA Kit
S100A4 ELISA Kit for Homo sapiens (Human)
產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL020632HU | Human Protein S100-A4(S100A4) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.225 ng/mL |
S100A4 ELISA Kit for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL020632MO | Mouse Protein S100-A4(S100A4) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 15.6 pg/mL |