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  4. Human Eotaxin 2/CCL24 ELISA Kit

Human Eotaxin 2/CCL24 ELISA Kit

  • 中文名稱：
    人嗜酸粒細(xì)胞趨化蛋白Eotaxin 2(Eotaxin 2/CCL24)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E10360h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人嗜酸粒細(xì)胞趨化蛋白Eotaxin 2(Eotaxin 2/CCL24)酶聯(lián)免疫試劑盒（CSB-E10360h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL24含量。CCL24，也稱為嗜酸性粒細(xì)胞趨化蛋白2（eotaxin-2）和骨髓祖細(xì)胞抑制因子2（MPIF-2），是CC趨化因子家族的一種小細(xì)胞因子，位于人類基因組第7號染色體上。CCL24通過與CCR3受體結(jié)合，誘導(dǎo)嗜酸性粒細(xì)胞趨化性，介導(dǎo)特應(yīng)性疾病、寄生蟲感染和全身性疾病，并促進(jìn)細(xì)胞運輸和調(diào)節(jié)炎癥及纖維化活動。研究顯示，褪黑激素能抑制CCL24的表達(dá)，從而抑制骨肉瘤細(xì)胞的轉(zhuǎn)移和侵襲。試劑盒檢測范圍為78.125 pg/mL-5000 pg/mL，靈敏度為67.660 pg/mL。該產(chǎn)品適用于基礎(chǔ)醫(yī)學(xué)研究中探索過敏性哮喘、特應(yīng)性皮炎等Th2型免疫反應(yīng)相關(guān)疾病的分子機制，也可用于體外藥物篩選模型中評估化合物對CCL24表達(dá)水平的調(diào)控作用，為炎癥微環(huán)境研究、免疫細(xì)胞趨化行為分析等科研領(lǐng)域提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    C C motif chemokine 24 ELISA Kit; C-C motif chemokine 24 ELISA Kit; CCL24 ELISA Kit; CCL24_HUMAN ELISA Kit; Chemokine CC Motif Ligand 24 ELISA Kit; CK beta 6 ELISA Kit; CK-beta-6 ELISA Kit; Ckb6 ELISA Kit; Eosinophil chemotactic protein 2 ELISA Kit; Eotaxin-2 ELISA Kit; MPIF 2 ELISA Kit; MPIF-2 ELISA Kit; MPIF2 ELISA Kit; Myeloid progenitor inhibitory factor 2 ELISA Kit; SCYA24 ELISA Kit; Small inducible cytokine A24 ELISA Kit; Small inducible cytokine subfamily A (Cys-Cys) member 24 ELISA Kit; Small-inducible cytokine A24 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78.125 pg/mL-5000 pg/mL
  • 靈敏度：
    67.660 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human eotaxin 2/CCL24 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 95    
    Range % 90-100    
    1:2 Average % 89    
    Range % 85-94    
    1:4 Average % 96    
    Range % 91-101    
    1:8 Average % 104    
    Range % 100-108    
  • 回收率：
    The recovery of human eotaxin 2/CCL24 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 99 95-103    
    EDTA plasma (n=4) 86 83-89    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    5000 2.152 2.204 2.178 2.065    
    2500 1.796 1.735 1.766 1.653    
    1250 1.182 1.205 1.194 1.081    
    625 0.765 0.798 0.782 0.669    
    312.5 0.453 0.468 0.461 0.348    
    156.25 0.328 0.331 0.330 0.217    
    78.125 0.251 0.240 0.246 0.133    
    0 0.115 0.110 0.113 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 最新研究進(jìn)展：
        CCL24是一種細(xì)胞因子，主要由T淋巴細(xì)胞和單核細(xì)胞產(chǎn)生，可通過調(diào)節(jié)免疫細(xì)胞的遷移和激活來參與多種疾病的發(fā)生和發(fā)展。近年來的研究表明，CCL24在哮喘和過敏性鼻炎中發(fā)揮重要作用，并與疾病的病理生理過程密切相關(guān)。
     
  • 功能：
    Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.
  • 基因功能參考文獻(xiàn)：
    1. Study showed that CCL24 was upregulated in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis in HCC patients . Also, CCL24 was associated with the metastatic potential of HCC cell lines and promoted proliferation, migration, and invasion. PMID: 28042950
    2. Mean eotaxin 2 concentrations in nasal fluid in patients with perennial allergic rhinitis and nonallergic and allergic chronic rhinosinusitis with nasal polyps patients were significantly higher in comparison to control subjects. PMID: 28587510
    3. HMGB1 did not elicit chemotaxis of human eosinophils alone and had no effect in combination with the eosinophil chemotactic agent, eotaxin-2 (CCL24). PMID: 25774667
    4. these data suggest that CCL26 and CCL24 are likely involved in the pathogenesis of chronic nasal hypereosinophilia, with a complex cooperation and different involvement of the various members of eotaxin family. PMID: 24989688
    5. Pregnancy associated environments increased local CCL24/CCR3, supporting the process of decidualization in human early pregnancy. PMID: 23696919
    6. Phosphodiesterase 4 inhibitors, rolipram and RO-20-1724 have no effect on CCL24 expression in human primary bronchial epithelial cells. PMID: 22946025
    7. Study shows that CCL24 levels were significantly increased in age-related macular degeneration (AMD) patients despite Avastin treatment as compared with normal controls and those without Avastin. PMID: 23025269
    8. CCR3 is differentially expressed on inflammatory cells in rheumatoid arthritis, while eotaxin-2, a potent CCR3 agonist, is differentially expressed in active disease. PMID: 20659406
    9. stimulates lung fibroblast proliferation and collagen synthesis PMID: 20143648
    10. alters eosinophil integrin function via mitogen-activated protein kinases PMID: 12034562
    11. Intradermal injection of CCL24 induces recruitment of eosinophils, basophils, neutrophils, and macrophages as well as features of early- and late-phase allergic reactions in atopic and nonatopic volunteers. PMID: 12193745
    12. Plasma eotaxin-2 concentrations differed in asthmatic patients with respect to aspirin intolerance and tolerance, indicating that eotaxin-2 may be differentially up-regulated according to aspirin intolerance. PMID: 16304252
    13. Our results suggest that Eo2 +179T>C and Eo2 +275C>T of eotaxin-2 might be associated with the susceptibility of ulcerative colitis. PMID: 16391516
    14. These data support the idea that CCL24/eotaxin-2 is part of the mechanism of CD4 lymphocyte activation paracrinally induced by Nef. PMID: 17630924
    15. eotaxin-2 is a chemokine strongly associated with primary and metastatic tumors of colorectal origin PMID: 17908961
    16. the ability to produce eotaxin-2/CCL24 is acquired during the differentiation into eosinophilic lineage which is dependent on GATA-1 expression PMID: 17917245
    17. This protein is an eosinophil chemoattractant that is up-regulated by human rhinovirus infection in cultured bronchial epithelial cells. PMID: 11467997

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Activated monocytes and activated T lymphocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10623

    OMIM: 602495

    KEGG: hsa:6369

    STRING: 9606.ENSP00000222902

    UniGene: Hs.247838



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