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PDCD1

PDCD1,即程序性細胞死亡蛋白1,也稱為PD1、CD279、hSLE1,由人類PDCD1基因編碼,該基因位于2號染色體的q37.3位置。PDCD1蛋白是一種重要的免疫抑制受體,屬于免疫球蛋白超家族成員,主要在激活的T細胞和B細胞上表達
其作用機制涉及與配體PD-L1和PD-L2的結合,啟動T細胞的程序性死亡,從而抑制T細胞的活化和增殖。
PDCD1在維持外周T、B細胞耐受中發揮重要作用,其增強信號可以下調已活化的T、B細胞在外周組織中的應答。PDCD1的異常表達與多種自身免疫疾病、感染性疾病和腫瘤相關,是免疫治療的重要靶點。

熱銷產品

Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active) (CSB-MP619964HU1)

驗證數據

CSB-MP619964HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-MP619964HU1

Activity
①Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP619964HU1

Activity
②Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Nivolumab, the EC50 of human PD-1 protein is 9.713-12.39 ng/ml.

CSB-MP619964HU1

The purity of PDCD1 was greater than 95% as determined by SEC-HPLC

PDCD1 Recombinant Monoclonal Antibody (CSB-RA240597A0HU)

驗證數據

CSB-RA240597A0HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: PD1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 32 KDa
Observed band size: 32 kDa

CSB-RA240597A0HU

IHC image of CSB-RA240597A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

PDCD1 Antibodies

PDCD1 for Homo sapiens (Human)

PDCD1 Proteins

PDCD1 Proteins for Homo sapiens (Human)

PDCD1 ELISA Kit

PDCD1 ELISA Kit for Homo sapiens (Human)

PDCD1 ELISA Kit for Mus musculus (Mouse)



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