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TLR4

TLR4全名Toll樣受體4,也被稱為CD284或hToll,是機(jī)體感知病原體入侵的重要"哨兵"。TLR4主要駐扎在免疫細(xì)胞表面,能夠敏銳識別細(xì)菌脂多糖等危險信號,迅速激活防御系統(tǒng)。當(dāng)它與特定分子結(jié)合時,會聯(lián)動細(xì)胞內(nèi)多種信號分子,促使免疫細(xì)胞釋放炎性因子,同時協(xié)調(diào)吞噬細(xì)胞清除病原體。這種快速反應(yīng)機(jī)制在對抗感染中不可或缺,但過度激活可能引發(fā)全身炎癥風(fēng)暴。
TLR4功能失衡與多種疾病密切相關(guān)。在敗血癥和急性呼吸窘迫綜合征患者中,其異常活躍會加劇組織損傷;而在某些腫瘤微環(huán)境和慢性感染中,其活性抑制又可能導(dǎo)致免疫應(yīng)答不足。近年來針對該靶點(diǎn)的藥物研發(fā)聚焦于調(diào)控其活性窗口,例如TAK-242等抑制劑曾嘗試用于膿毒癥治療,新型納米抗體則探索在自身免疫病中的應(yīng)用。部分研究團(tuán)隊(duì)正嘗試將其調(diào)控劑與化療藥物聯(lián)用,以改善腫瘤免疫治療效果。

熱銷產(chǎn)品

Recombinant Human Toll-like receptor 4 (TLR4), partial (CSB-EP023603HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP023603HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TLR4 Recombinant Monoclonal Antibody (CSB-RA023603MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA023603MA1HU

Overlay Peak curve showing Hela cells stained with CSB-RA023603MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human toll-like receptor 4,TLR4 ELISA Kit (CSB-E12954h)

驗(yàn)證數(shù)據(jù)

CSB-E12954h 標(biāo)準(zhǔn)曲線

貨號:CSB-E12954h

規(guī)格:96T/48T

靈敏度:0.039 ng/mL

檢測范圍:0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TLR4 Antibodies

TLR4 for Homo sapiens (Human)

TLR4 Proteins

TLR4 Proteins for Felis catus (Cat) (Felis silvestris catus)

TLR4 Proteins for Homo sapiens (Human)

TLR4 Proteins for Sus scrofa (Pig)

TLR4 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

TLR4 Proteins for Pongo pygmaeus (Bornean orangutan)

TLR4 Proteins for Bos taurus (Bovine)

TLR4 Proteins for Equus caballus (Horse)

TLR4 Proteins for Rattus norvegicus (Rat)

TLR4 Proteins for Papio anubis (Olive baboon)

TLR4 Proteins for Mus musculus (Mouse)

TLR4 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

TLR4 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

TLR4 Proteins for Boselaphus tragocamelus (Nilgai)

TLR4 ELISA Kit

TLR4 ELISA Kit for Homo sapiens (Human)

TLR4 ELISA Kit for Mus musculus (Mouse)

TLR4 ELISA Kit for Rattus norvegicus (Rat)



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