在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH)

  • 中文名稱:
    人DHODH重組蛋白
  • 貨號:
    CSB-CF006852HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    DHODH
  • Uniprot No.:
  • 別名:
    DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondrial; POADS; PYRD_HUMAN; URA1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-395
  • 氨基酸序列
    MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    10xHis-SUMO-tag
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
  • 基因功能參考文獻:
    1. This case with grossly raised plasma DHO represents the first biochemical confirmation of functional DHODH deficiency. DHO was also easily detectable in dried plasma and blood spots. PMID: 27370710
    2. This is the first study to report on conformational changes of the HsDHODH N-terminal microdomain through a combination of CD and DEER spectroscopic techniques PMID: 26086954
    3. Considering that pyrimidine deficiency alone does not induce craniofacial dysmorphism, the DHODH mutations may contribute to the Miller syndrome in part through somehow altered mitochondrial function. PMID: 23216091
    4. Carriage of a six-marker DHODH haplotype was associated with a reduced treatment response (p = 0.008). PMID: 22966891
    5. The G202A and R346W mutation causes deficient protein stability, and the R135C mutation impairs the substrate-induced enzymatic activity, suggesting that impairment of DHODH activity is linked to the Miller syndrome phenotype. PMID: 22967083
    6. biallelic DHODH mutations in four unrelated families with typical clinical features of Miller syndrome. PMID: 22692683
    7. DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in xenograft studies PMID: 21430780
    8. DHODH recessively causes Miller syndrome. PMID: 20220176
    9. required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis of cancer epithelial cells PMID: 20399851
    10. Data confirmed the presence of DHODH mutations in families with Miller syndrome. PMID: 19915526
    11. biophysical analysis of hydrogen bonding pathways in human dihydroorotate dehydrogenase PMID: 17004840
    12. Data provide new insights into the dynamic features of the DHODH reaction and suggest new approaches to the design of inhibitors against DHODH. PMID: 18672895
    13. DHODH polymorphism may be associated with incireased remiaaion in leflunomide treatment in rheumatoid arthritis patients. PMID: 19207032
    14. we report a new association of DHODH A40C polymorphism with leflunomide toxicity in patients with Rheumatoid Arthritis. PMID: 19605743

    顯示更多

    收起更多

  • 相關疾病:
    Postaxial acrofacial dysostosis (POADS)
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族:
    Dihydroorotate dehydrogenase family, Type 2 subfamily
  • 數據庫鏈接:

    HGNC: 2867

    OMIM: 126064

    KEGG: hsa:1723

    STRING: 9606.ENSP00000219240

    UniGene: Hs.654427



主站蜘蛛池模板: 99精品国产在热久久婷婷 | 色插图午夜影院| 日本护士╳╳╳hd少妇| 欧美成 人版中文字幕| 中文字幕av伊人av无码av狼人| 亚洲人毛茸茸bbxx| 韩国精品一区二区无码视频| 免费国产a国产片高清网站| 国产经典三级av在线播放| 综合图区亚洲欧美另类图片| 丰满人妻妇伦又伦精品国产| 国产亚洲精品久久久久久小说| 国产一卡2卡3卡四卡精品国色无边| 精品偷拍一区二区三区在线看| 俄罗斯丰满熟妇hd| 影音先锋在线亚洲网站 | 国色天香社区视频| 国产日产亚洲系列最新| 精品国产乱码久久久久app下载| 色94色欧美sute亚洲线路一| 久久久久久久性潮| 三级视频兔费看| 无码国产一区二区三区四区| 精品一品国产午夜福利视频| 性色av一区二区三区无码| 亚洲精品国产成人精品| 国产成人无码av大片大片在线观看| 成人免费ā片在线观看| 国产午夜成人av在线播放| 国产日产欧产精品精品免费| 国产在线视频一区二区三区98| 国产人妻一区二区三区久| 久久久综合九色综合88| 国产成人无码视频网站在线观看| 国产真人性做爰久久网站| 精品国产不卡一区二区三区| 国产日韩未满十八禁止观看| 少妇被又大又粗又爽毛片久久黑人| 一区二区三区人妻无码| yyyy11111少妇影院| 国产熟睡乱子伦午夜视频麻豆|