在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Dihydroorotate dehydrogenase (quinone),mitochondrial (DHODH), partial

In Stock
  • 中文名稱:
    人DHODH重組蛋白
  • 貨號:
    CSB-EP006852HU1b0
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    DHODH
  • Uniprot No.:
  • 別名:
    DHOdehase; Dhodh; Dihydroorotate dehydrogenase (quinone); Dihydroorotate dehydrogenase; Dihydroorotate dehydrogenase mitochondrial; Dihydroorotate oxidase; Human complement of yeast URA1; mitochondrial; POADS; PYRD_HUMAN; URA1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    45.1kDa
  • 表達區域:
    31-395aa
  • 氨基酸序列
    TGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
  • 基因功能參考文獻:
    1. This case with grossly raised plasma DHO represents the first biochemical confirmation of functional DHODH deficiency. DHO was also easily detectable in dried plasma and blood spots. PMID: 27370710
    2. This is the first study to report on conformational changes of the HsDHODH N-terminal microdomain through a combination of CD and DEER spectroscopic techniques PMID: 26086954
    3. Considering that pyrimidine deficiency alone does not induce craniofacial dysmorphism, the DHODH mutations may contribute to the Miller syndrome in part through somehow altered mitochondrial function. PMID: 23216091
    4. Carriage of a six-marker DHODH haplotype was associated with a reduced treatment response (p = 0.008). PMID: 22966891
    5. The G202A and R346W mutation causes deficient protein stability, and the R135C mutation impairs the substrate-induced enzymatic activity, suggesting that impairment of DHODH activity is linked to the Miller syndrome phenotype. PMID: 22967083
    6. biallelic DHODH mutations in four unrelated families with typical clinical features of Miller syndrome. PMID: 22692683
    7. DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in xenograft studies PMID: 21430780
    8. DHODH recessively causes Miller syndrome. PMID: 20220176
    9. required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis of cancer epithelial cells PMID: 20399851
    10. Data confirmed the presence of DHODH mutations in families with Miller syndrome. PMID: 19915526
    11. biophysical analysis of hydrogen bonding pathways in human dihydroorotate dehydrogenase PMID: 17004840
    12. Data provide new insights into the dynamic features of the DHODH reaction and suggest new approaches to the design of inhibitors against DHODH. PMID: 18672895
    13. DHODH polymorphism may be associated with incireased remiaaion in leflunomide treatment in rheumatoid arthritis patients. PMID: 19207032
    14. we report a new association of DHODH A40C polymorphism with leflunomide toxicity in patients with Rheumatoid Arthritis. PMID: 19605743

    顯示更多

    收起更多

  • 相關疾病:
    Postaxial acrofacial dysostosis (POADS)
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein.
  • 蛋白家族:
    Dihydroorotate dehydrogenase family, Type 2 subfamily
  • 數據庫鏈接:

    HGNC: 2867

    OMIM: 126064

    KEGG: hsa:1723

    STRING: 9606.ENSP00000219240

    UniGene: Hs.654427



主站蜘蛛池模板: 人妻人人看人妻人人添| 亚洲成av人片一区二区| 久久久久噜噜噜亚洲熟女综合| 狠狠久久噜噜熟女| 国产欧美另类久久久精品丝瓜| 亚洲丰满熟妇在线播放电影全集| 成人性做爰aaa片免费看不忠| 天天躁日日躁狠狠躁超碰97| 日本国产网曝视频在线观看| 无码伊人66久久大杳蕉网站谷歌| 永久黄网站色视频免费直播| 亚洲精品无码久久久久久久| 免费看成人午夜福利专区| 女高中生自慰污污网站| 无码成a毛片免费| 国产在线精品一区二区| 日本欧美一区二区免费视频| 大胆日本熟妇xxxx| 99久热在线精品视频观看| 亚洲一卡2卡3卡4卡 精品| 丝袜熟女国偷自产中文字幕亚洲 | 国产精品秘入口18禁麻豆免会员| 日日av色欲香天天综合网| 少妇熟女久久综合网色欲| 国产人成无码视频在线观看| 国产成人精品三上悠亚| 伊人无码精品久久一区二区| 狠狠色丁香久久综合| 国产精品久久久影视青草| 免费无码a片一区二三区| 久久只有这里有精品4| 国产精品久久久久久久久久久免费看| 狠狠色综合网站久久久久久久高清| 免费h动漫无码网站| 色综合视频一区二区三区44| 人妻熟女一区二区aⅴ水野朝阳| 天天躁人人躁人人躁狂躁| 搡8o老女人老妇人老熟| 五月婷六月婷婷俺也去| 经典三级欧美在线播放| 国产亚洲精品自在久久|