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  4. Recombinant Human Transport and Golgi organization protein 1 homolog (MIA3), partial

Recombinant Human Transport and Golgi organization protein 1 homolog (MIA3), partial

  • 中文名稱：
    人MIA3重組蛋白
  • 貨號：
    CSB-YP711448HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MIA3重組蛋白
  • 貨號：
    CSB-EP711448HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MIA3重組蛋白
  • 貨號：
    CSB-EP711448HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MIA3重組蛋白
  • 貨號：
    CSB-BP711448HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MIA3重組蛋白
  • 貨號：
    CSB-MP711448HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MIA3
  • Uniprot No.：
  • 別名：
    ARNT; C219 reactive peptide; C219-reactive peptide; D320; Melanoma inhibitory activity family; member 3; Melanoma inhibitory activity protein 3; Mia3; MIA3_HUMAN; RP11-378J18.4; TANGO; Transport and Golgi organization protein 1; UNQ6077
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES.
  • 基因功能參考文獻：
    1. ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis. PMID: 28341552
    2. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
    3. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion. PMID: 28442536
    4. TANGO1 is thus pivotal in concentrating procollagen VII in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum. PMID: 26568311
    5. TANGO expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma. PMID: 24889917
    6. We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese. PMID: 24125424
    7. results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis PMID: 22577832
    8. genetic polymorphism is associated with an increased risk of myocardial infarction PMID: 21264445
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20738937
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20971364
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20694560
    12. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    13. TANGO transfected cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration. PMID: 17044017
    14. The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells. PMID: 17726152
    15. Reduced expression of TANGO is associated with colon and hepatocellular carcinomas PMID: 17786351
    16. Observational study of gene-disease association. (HuGE Navigator) PMID: 19955471
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 19336575
    18. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19198609

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    MIA/OTOR family, Tango1 subfamily
  • 組織特異性：
    Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24008

    OMIM: 613455

    KEGG: hsa:375056

    STRING: 9606.ENSP00000340900

    UniGene: Hs.118474



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