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  4. MIA3 Antibody, Biotin conjugated

MIA3 Antibody, Biotin conjugated

  • 中文名稱：
    MIA3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA711448LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) MIA3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MIA3
  • 別名：
    ARNT antibody; C219 reactive peptide antibody; C219-reactive peptide antibody; D320 antibody; Melanoma inhibitory activity family; member 3 antibody; Melanoma inhibitory activity protein 3 antibody; Mia3 antibody; MIA3_HUMAN antibody; RP11-378J18.4 antibody; TANGO antibody; Transport and Golgi organization protein 1 antibody; UNQ6077 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Transport and Golgi organization protein 1 homolog protein (1447-1626AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES.
  • 基因功能參考文獻：
    1. ADTRP positively regulates PIK3R3 expression, which leads to activation of AKT and up-regulation of MIA3/TANGO1, thereby regulating endothelial cell functions directly relevant to atherosclerosis. PMID: 28341552
    2. TANGO1/CTAGE5 receptor serves as a polyvalent template for assembly of large COPII coats. PMID: 27551091
    3. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion. PMID: 28442536
    4. TANGO1 is thus pivotal in concentrating procollagen VII in the lumen and recruiting ERGIC membranes on the cytoplasmic surface of the endoplasmic reticulum. PMID: 26568311
    5. TANGO expression was strongly associated with tumour progression, nodal metastasis, clinical stage and number of blood or lymph vessels in oral squamous cell carcinoma. PMID: 24889917
    6. We conclude that SNP rs17465637 in MIA3 is indeed a genetic risk factor for CAD across different ethnic populations including Han Chinese. PMID: 24125424
    7. results suggest a potential association of the MIA3 rs17465637 with cardiovascular disease in dyslipidemic patients with rheumatoid arthritis PMID: 22577832
    8. genetic polymorphism is associated with an increased risk of myocardial infarction PMID: 21264445
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20738937
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20971364
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 20694560
    12. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    13. TANGO transfected cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration. PMID: 17044017
    14. The results from this study present TANGO as a novel ligand for CD11c, regulating migratory processes of hematopoietic cells. PMID: 17726152
    15. Reduced expression of TANGO is associated with colon and hepatocellular carcinomas PMID: 17786351
    16. Observational study of gene-disease association. (HuGE Navigator) PMID: 19955471
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 19336575
    18. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19198609

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  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    MIA/OTOR family, Tango1 subfamily
  • 組織特異性：
    Broadly expressed, except in bone marrow and peripheral blood mononuclear cells. Down-regulated in melanoma tissue.
  • 數據庫鏈接：

    HGNC: 24008

    OMIM: 613455

    KEGG: hsa:375056

    STRING: 9606.ENSP00000340900

    UniGene: Hs.118474



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