在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Galactokinase (GALK1)

  • 中文名稱:
    人GALK1重組蛋白
  • 貨號:
    CSB-YP009198HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人GALK1重組蛋白
  • 貨號:
    CSB-EP009198HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人GALK1重組蛋白
  • 貨號:
    CSB-EP009198HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人GALK1重組蛋白
  • 貨號:
    CSB-BP009198HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人GALK1重組蛋白
  • 貨號:
    CSB-MP009198HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    GALK1
  • Uniprot No.:
  • 別名:
    EC 2.7.1.6; epididymis secretory protein Li 19; Galactokinase 1; Galactokinase; Galactose kinase; GALK 1; GALK; GALK1; GALK1_HUMAN; GK1; GLK; GLK1; HEL-S-19
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-392
  • 氨基酸序列
    MAALRQPQVA ELLAEARRAF REEFGAEPEL AVSAPGRVNL IGEHTDYNQG LVLPMALELM TVLVGSPRKD GLVSLLTTSE GADEPQRLQF PLPTAQRSLE PGTPRWANYV KGVIQYYPAA PLPGFSAVVV SSVPLGGGLS SSASLEVATY TFLQQLCPDS GTIAARAQVC QQAEHSFAGM PCGIMDQFIS LMGQKGHALL IDCRSLETSL VPLSDPKLAV LITNSNVRHS LASSEYPVRR RQCEEVARAL GKESLREVQL EELEAARDLV SKEGFRRARH VVGEIRRTAQ AAAALRRGDY RAFGRLMVES HRSLRDDYEV SCPELDQLVE AALAVPGVYG SRMTGGGFGG CTVTLLEASA APHAMRHIQE HYGGTATFYL SQAADGAKVL CL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Major enzyme for galactose metabolism.
  • 基因功能參考文獻:
    1. Mutation in the GALK gene is associated with mental disorders in galactosemia. PMID: 28672748
    2. The GALK1 gene was included in this interval and direct sequencing. PMID: 24211322
    3. Data indicate taht the interactions between galactokinase (GALK) and its potential inhibitors by molecular dynamics simulations. PMID: 23517731
    4. The study highlighted the importance of GALK gene analysis in diagnosis of galactosemia in Indian population. PMID: 22632133
    5. A possible mechanism for the unfolding caused by the Pro(28)Thr point mutation of human galactokinase. PMID: 21264483
    6. Pathogenic mutations in GALK1 that are responsible for autosomal recessive congenital cataracts in consanguineous Pakistani families, are reported. PMID: 20405025
    7. 2 new GALK1 mutations near the ATP-binding site were found in a homozygotic Turkish immigrant: S142I and G148C. PMID: 11978883
    8. a functional analysis of disease-causing mutations in this enzyme PMID: 12694189
    9. In this northern Italian population age-related cataract does not appear to be associated with GALK1 alleles. PMID: 12942049
    10. structure and function of galactokinase, and role in type II galactosemia [review] PMID: 15526155
    11. active site geometry of this enzyme upon which to more fully understand the consequences of the those mutations known to give rise to Type II galactosemia. PMID: 15590630
    12. Mutations in GALK1 resulted in reduction of GALK activity and caused GALK deficiency. PMID: 17517531
    13. These results suggest that the elevated GALK1 activity resulted from enhanced gene expression, due to nucleotide variation within GALK1 promoter PMID: 19309526
    14. Structure of the human enzyme complexed with MgAMP.PNP and galactose PMID: 15590630
    15. The disease-causing point mutations in the human enzyme are mapped onto the structure of the protein from Pyrococcus furiosus and speculations made about the structural consequences. PMID: 15003454
    16. 2-deoxy-D-galactose is a substrate for this enzyme. D-glucose, D-fucose, L-arabinose and N-acetyl-D-galactosamine are not. Mutations H44A, H44I, E43G/H44I are insoluble, D46A is inactive, E43G has reduced activity and E43A has wild-type activity. PMID: 14596685
    17. Has ordered ternary complex mechanism with ATP being the first substrate to bind. PMID: 12694189

    顯示更多

    收起更多

  • 相關疾病:
    Galactosemia II (GALCT2)
  • 蛋白家族:
    GHMP kinase family, GalK subfamily
  • 數據庫鏈接:

    HGNC: 4118

    OMIM: 230200

    KEGG: hsa:2584

    STRING: 9606.ENSP00000225614

    UniGene: Hs.407966



主站蜘蛛池模板: 亚洲国产精品无码久久98| 久久这里只有是精品23| 久久天堂av综合合色| 精品国产青草久久久久福利| 国产又色又爽又黄的| 青青久在线视观看视| 中文字幕av无码免费久久| 综合亚洲伊人午夜网| 51国产黑色丝袜高跟鞋| 国产成人手机高清在线观看网站 | 国产精品无码一区二区在线| 日夜啪啪一区二区三区| 在线精品亚洲第一区焦香| 亚洲美女又黄又爽在线观看| 极品少妇hdxx麻豆hdxx| 欧美人与动人物姣配xxxx | 日韩成人无码v清免费| 人妻无码中字在线a| 亚洲另类春色校园小说| 国产亚洲精品97在线视频一| 中文字幕第一区高清av| 中文字幕在线精品视频入口一区 | 久久精品国产曰本波多野结衣| 日产精品卡1卡2卡三卡在线| 狠狠色噜噜狠狠狠狠777米奇小说 又黄又爽的60分钟视频 | 国产美女久久精品香蕉| 中国少妇内射xxxhd免费| 久久99精品久久久久久秒播| 综合激情丁香久久狠狠| 亚洲精品aa片在线观看国产| 1000部拍拍拍18勿入免费视频下载| 好男人社区www在线官网| 久久综合a∨色老头免费观看| 热re99久久精品国产99热| 奇米影视888欧美在线观看| 亚洲精品日本一区二区三区| 18禁美女裸体无遮挡免费观看国产| 亚洲精品色午夜无码专区日韩| 中国熟妇牲交视频免费| 亚洲 小说 欧美 另类 社区| 少妇放荡的呻吟干柴烈火免费视频 |