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  4. GALK1 Antibody

GALK1 Antibody

  • 中文名稱：
    GALK1兔多克隆抗體
  • 貨號：
    CSB-PA073623
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA073623(GALK1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA073623(GALK1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue, Primary antibody: CSB-PA073623(GALK1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    GALK1
  • 別名：
    EC 2.7.1.6 antibody; epididymis secretory protein Li 19 antibody; Galactokinase 1 antibody; Galactokinase antibody; Galactose kinase antibody; GALK 1 antibody; GALK antibody; GALK1 antibody; GALK1_HUMAN antibody; GK1 antibody; GLK antibody; GLK1 antibody; HEL-S-19 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human GALK1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Major enzyme for galactose metabolism.
  • 基因功能參考文獻：
    1. Mutation in the GALK gene is associated with mental disorders in galactosemia. PMID: 28672748
    2. The GALK1 gene was included in this interval and direct sequencing. PMID: 24211322
    3. Data indicate taht the interactions between galactokinase (GALK) and its potential inhibitors by molecular dynamics simulations. PMID: 23517731
    4. The study highlighted the importance of GALK gene analysis in diagnosis of galactosemia in Indian population. PMID: 22632133
    5. A possible mechanism for the unfolding caused by the Pro(28)Thr point mutation of human galactokinase. PMID: 21264483
    6. Pathogenic mutations in GALK1 that are responsible for autosomal recessive congenital cataracts in consanguineous Pakistani families, are reported. PMID: 20405025
    7. 2 new GALK1 mutations near the ATP-binding site were found in a homozygotic Turkish immigrant: S142I and G148C. PMID: 11978883
    8. a functional analysis of disease-causing mutations in this enzyme PMID: 12694189
    9. In this northern Italian population age-related cataract does not appear to be associated with GALK1 alleles. PMID: 12942049
    10. structure and function of galactokinase, and role in type II galactosemia [review] PMID: 15526155
    11. active site geometry of this enzyme upon which to more fully understand the consequences of the those mutations known to give rise to Type II galactosemia. PMID: 15590630
    12. Mutations in GALK1 resulted in reduction of GALK activity and caused GALK deficiency. PMID: 17517531
    13. These results suggest that the elevated GALK1 activity resulted from enhanced gene expression, due to nucleotide variation within GALK1 promoter PMID: 19309526
    14. Structure of the human enzyme complexed with MgAMP.PNP and galactose PMID: 15590630
    15. The disease-causing point mutations in the human enzyme are mapped onto the structure of the protein from Pyrococcus furiosus and speculations made about the structural consequences. PMID: 15003454
    16. 2-deoxy-D-galactose is a substrate for this enzyme. D-glucose, D-fucose, L-arabinose and N-acetyl-D-galactosamine are not. Mutations H44A, H44I, E43G/H44I are insoluble, D46A is inactive, E43G has reduced activity and E43A has wild-type activity. PMID: 14596685
    17. Has ordered ternary complex mechanism with ATP being the first substrate to bind. PMID: 12694189

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  • 相關疾病：
    Galactosemia II (GALCT2)
  • 蛋白家族：
    GHMP kinase family, GalK subfamily
  • 數據庫鏈接：

    HGNC: 4118

    OMIM: 230200

    KEGG: hsa:2584

    STRING: 9606.ENSP00000225614

    UniGene: Hs.407966



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