在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA topoisomerase I, mitochondrial (TOP1MT)

  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-YP853372HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-EP853372HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-EP853372HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-BP853372HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-MP853372HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TOP1MT
  • Uniprot No.:
  • 別名:
    TOP1MT; DNA topoisomerase I; mitochondrial; TOP1mt; EC 5.6.2.1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    51-601
  • 氨基酸序列
    VKWRQLEHKG PYFAPPYEPL PDGVRFFYEG RPVRLSVAAE EVATFYGRML DHEYTTKEVF RKNFFNDWRK EMAVEEREVI KSLDKCDFTE IHRYFVDKAA ARKVLSREEK QKLKEEAEKL QQEFGYCILD GHQEKIGNFK IEPPGLFRGR GDHPKMGMLK RRITPEDVVI NCSRDSKIPE PPAGHQWKEV RSDNTVTWLA AWTESVQNSI KYIMLNPCSK LKGETAWQKF ETARRLRGFV DEIRSQYRAD WKSREMKTRQ RAVALYFIDK LALRAGNEKE DGEAADTVGC CSLRVEHVQL HPEADGCQHV VEFDFLGKDC IRYYNRVPVE KPVYKNLQLF MENKDPRDDL FDRLTTTSLN KHLQELMDGL TAKVFRTYNA SITLQEQLRA LTRAEDSIAA KILSYNRANR VVAILCNHQR ATPSTFEKSM QNLQTKIQAK KEQVAEARAE LRRARAEHKA QGDGKSRSVL EKKRRLLEKL QEQLAQLSVQ ATDKEENKQV ALGTSKLNYL DPRISIAWCK RFRVPVEKIY SKTQRERFAW ALAMAGEDFE F
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
  • 基因功能參考文獻:
    1. This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. PMID: 28874393
    2. Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. PMID: 24172750
    3. DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. PMID: 23261817
    4. Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. PMID: 23422507
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Type IB topoisomerase family
  • 組織特異性:
    Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
  • 數據庫鏈接:

    HGNC: 29787

    OMIM: 606387

    KEGG: hsa:116447

    STRING: 9606.ENSP00000328835

    UniGene: Hs.528574



主站蜘蛛池模板: 久久99国产精品久久| 伊人精品成人久久综合| 亚洲精品tv久久久久久久久j | 兔费看少妇性l交大片免费| 高潮内射免费看片| 国内精品久久久久影院老司机 | 日日摸天天碰中文字幕你懂的| 国产xxxx69真实实拍| 无码8090精品久久一区| 特级a欧美做爰片第一次| 久青青视频在线观看久| 久久久久国色av免费看| 国产激情综合五月久久| 亚洲欧洲自拍拍偷精品 美利坚| 久久久亚洲欧洲日产国码二区 | 亚洲日韩看片无码超清| 亚洲精品偷拍影视在线观看 | 国产精成人品| 国产免费爽爽视频在线观看| 永久不封国产av毛片| 国产乱子影视频上线免费观看| 国产精品久久久久野外| 四虎影视国产精品久久| 无码三级国产三级在线电影| 国产高清在线精品一区下载 | 青青青青国产免费线在线观看| 亚洲另类欧美在线电影| 漂亮人妻洗澡被公强 日日躁| 国产卡一卡二卡三无线乱码新区| 久久www香蕉免费人成| 久久精品国产男包| www成人国产高清内射| 国产一区二区波多野结衣| 欧美肥胖老太vidio在线视频| 中文字幕一区日韩精品| 久久亚洲精品中文字幕无码| 国产精品人妻一区夜夜爱| 亚洲色无码专区在线播放| 狂野欧美激情性xxxx按摩| 亚洲成a∨人片在线观看不卡| 久久亚洲精品无码网站|