在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human DNA topoisomerase I, mitochondrial (TOP1MT)

  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-YP853372HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-EP853372HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-EP853372HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-BP853372HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人TOP1MT重組蛋白
  • 貨號:
    CSB-MP853372HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    TOP1MT
  • Uniprot No.:
  • 別名:
    TOP1MT; DNA topoisomerase I; mitochondrial; TOP1mt; EC 5.6.2.1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    51-601
  • 氨基酸序列
    VKWRQLEHKG PYFAPPYEPL PDGVRFFYEG RPVRLSVAAE EVATFYGRML DHEYTTKEVF RKNFFNDWRK EMAVEEREVI KSLDKCDFTE IHRYFVDKAA ARKVLSREEK QKLKEEAEKL QQEFGYCILD GHQEKIGNFK IEPPGLFRGR GDHPKMGMLK RRITPEDVVI NCSRDSKIPE PPAGHQWKEV RSDNTVTWLA AWTESVQNSI KYIMLNPCSK LKGETAWQKF ETARRLRGFV DEIRSQYRAD WKSREMKTRQ RAVALYFIDK LALRAGNEKE DGEAADTVGC CSLRVEHVQL HPEADGCQHV VEFDFLGKDC IRYYNRVPVE KPVYKNLQLF MENKDPRDDL FDRLTTTSLN KHLQELMDGL TAKVFRTYNA SITLQEQLRA LTRAEDSIAA KILSYNRANR VVAILCNHQR ATPSTFEKSM QNLQTKIQAK KEQVAEARAE LRRARAEHKA QGDGKSRSVL EKKRRLLEKL QEQLAQLSVQ ATDKEENKQV ALGTSKLNYL DPRISIAWCK RFRVPVEKIY SKTQRERFAW ALAMAGEDFE F
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
  • 基因功能參考文獻:
    1. This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. PMID: 28874393
    2. Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. PMID: 24172750
    3. DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. PMID: 23261817
    4. Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. PMID: 23422507
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Type IB topoisomerase family
  • 組織特異性:
    Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
  • 數據庫鏈接:

    HGNC: 29787

    OMIM: 606387

    KEGG: hsa:116447

    STRING: 9606.ENSP00000328835

    UniGene: Hs.528574



主站蜘蛛池模板: 永久免费观看美女裸体视频的网站| 久久国产精品偷| 无码精品日韩中文字幕| 国产午夜精华2020在线| 国产明星裸体xxxx视频| 与子敌伦刺激对白播放| 人妻熟女αⅴ一区二区三区| 无修无码h里番在线播放网站| 亚洲制服丝袜自拍中文字幕| 麻豆果冻传媒2021精品传媒一区| 国产精品99久久免费黑人人妻| 国产薄丝脚交视频在线观看| 亚洲精品无码久久久久秋霞 | 4438xx亚洲最大五色丁香| 日韩去日本高清在线| 亚洲.日韩.欧美另类| 免费做a爰片久久毛片a片| 成人性生交大片免费看96| 无码专区―va亚洲v专区在线| 国产午夜福利在线观看视频_ | 波多野结衣一区二区三区av免费 | 人妻av无码一区二区三区| 亚洲精品成人无码中文毛片不卡 | 麻批好紧日起要舒服死了| 337p亚洲日本中国大胆69| 丝袜足控一区二区三区| 爆乳女仆高潮在线观看| 9re热国产这里只有精品| 国产成人av乱码免费观看| 国产伦久视频免费观看视频| 亚洲精品国产精品乱码视色| 免费观看四虎精品国产地址| 精品无码一区二区三区爱欲| 成 人影片 免费观看在线| 国产精品人成视频免费播放| 女人张开腿让男桶喷水高潮| 国产精品久久久久久爽爽爽床戏| 国产成人愉拍精品| 日产一区日产2区| 综合无码成人aⅴ视频在线观看 | 国语对白做受xxxxx在|