在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8), partial (Active)

In Stock
  • 中文名稱:
    人TNFSF8重組蛋白
  • 貨號:
    CSB-MP023996HU1
  • 規格:
    ¥816
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized CD30(CSB-MP023983HU1h6) at 5 μg/ml can bind human CD30L, the EC50 is 9.531-12.49 ng/ml. Biological Activity Assay
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/ug as determined by LAL method.
  • 生物活性:
    Measured by its binding ability in a functional ELISA. Immobilized CD30(CSB-MP023983HU1h6) at 5 μg/ml can bind human CD30L, the EC50 is 9.531-12.49 ng/ml.
  • 基因名:
  • Uniprot No.:
  • 別名:
    TNFSF8; CD30L; CD30LG; Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD antigen CD153
  • 分子結構:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    Mammalian cell
  • 分子量:
    21.8 kDa
  • 表達區域:
    63-234aa
  • 氨基酸序列
    QRTDSIPNSPDNVPLKGGNCSEDLLCILKRAPFKKSWAYLQVAKHLNKTKLSWNKDGILHGVRYQDGNLVIQFPGLYFIICQLQFLVQCPNNSVDLKLELLINKHIKKQALVTVCESGMQTKHVYQNLSQFLLDYLQVNTTISVNVDTFQYIDTSTFPLENVLSIFLYSNSD
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    Human TNFSF8 amino acids Gly21-Glu147 with N-terminal 6xHis-tag were expressed in mammalian cells. The resulting product is the recombinant human TNFSF8 protein. This TNFSF8 protein was validated by SDS-PAGE analysis, and its purity is greater than 75%. It migrated to the molecular mass band of about 22 kDa on the gel. Its endotoxin level is less than 1.0 EU/ug determined by the LAL method. This TNFSF8 protein can bind to the immobilized CD30 in the functional ELISA, with an EC50 of 9.531-12.49 ng/ml. It shows the TNFSF8 is an active protein. And it is available now.

    TNFSF8, also called CD30L or CD153, is primarily expressed on activated T and B cells eosinophils, and macrophages. CD30L/CD30 signaling is involved in Th1, Th2, Th17 cell responses, and Th1-, and Th2- associated diseases.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

平均分:
5.0分 - 1 個評價

實驗應用:結合實驗/蛋白間互作

產品評價: TNFSF8也被稱為CD30L或CD153,主要在活化的T細胞和B細胞嗜酸性粒細胞和巨噬細胞上表達。CD30L/CD30信號通路參與Th1, Th2, Th17細胞反應以及Th1-和Th2-相關疾病。CD30L和CD30有較好的結合活性,通過ELISA方法高通量篩選,建立起了穩定的篩選體系。

By 溫老師

靶點詳情

  • 功能:
    Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
  • 基因功能參考文獻:
    1. circulant sCD30L is functionally active and that it may favor persistence of active inflammation by inducing apoptosis of CD30(+)T cells, known to down-modulate inflammation in rheumatoid synovitis. PMID: 24447865
    2. TNFSF8 is an important leprosy T1R susceptibility gene. PMID: 25320285
    3. The heritability of IgA levels is moderate and can partly be attributable to common variation in the CD30L locus. PMID: 24676358
    4. The TNFSF8 polymorphisms rs927374 and rs2295800 were associated with neutrophil count. This finding suggests that post-MI inflammatory response is genetically modulated. PMID: 22033252
    5. Positional candidate gene screening in the SPA2 locus allowed us to identify and replicate an association between a rare SNP located in TNFSF8 and spondylarthritis. PMID: 21480186
    6. a possible role of novel TNFSF8 variants in susceptibility to lung cancer. PMID: 21292647
    7. capability to up-regulate expression of CD30, release of soluble CD30 and production of IL-4 in pre-activated T cells upon co-culture PMID: 11728464
    8. Mast cells were found to be the predominant CD30 ligand-positive (CD30L-positive) cell in the chronic inflammatory skin diseases psoriasis and atopic dermatitis. PMID: 16964309
    9. CD153 antigen was expressed by synovial mast cells, and correlated with serum levels, in Rheumatoid Arthritis patients PMID: 19208589
    10. Single nucleotide polymorphism in TNFSF8 gene is associated with bone disease in myeloma. PMID: 19657367

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Tumor necrosis factor family
  • 數據庫鏈接:

    HGNC: 11938

    OMIM: 603875

    KEGG: hsa:944

    STRING: 9606.ENSP00000223795

    UniGene: Hs.494901



主站蜘蛛池模板: 无码手机线免费观看| 久久亚洲春色中文字幕久久久 | 一边啪啪一边呻吟av夜夜嗨| 国产成人av在线一区二区三区| 亚洲国产av一区二区三区四区| 色妞色视频一区二区三区四区| 天天拍夜夜添久久精品| 无码人妻精品丰满熟妇区| 亚洲国产成人久久精品99| 国产精品自在拍在线拍| 精品无码一区二区三区在线| 欧美大黑帍在线播放| 99精品国产丝袜在线拍国语| 青青视频免费观看免费| 亚洲 日本 欧美 中文幕| 久久亚洲精精品中文字幕| 国产好爽…又高潮了毛片| 欧美综合乱图图区乱图图区 | 欧美熟妇性xxxx欧美熟人多毛| 国产精品18久久久久久麻辣| 国产熟妇勾子乱视频| 天堂8а√中文在线官网| 中文无码日韩欧免费视频| 无码丰满熟妇| 国产97超碰人人做人人爱| 色噜噜亚洲男人的天堂www| 国产又色又爽又刺激在线播放| 国模无码一区二区三区| 久久精品女人的天堂av| 18禁精品久久久国产精品久久久| 精品国产品香蕉在线| 老妇肥熟凸凹丰满刺激| 国产丰满乱子伦无码专区| 国产日产欧产精品品不卡| 成人无码www免费视频| 国产成人精品免费视频大全五级| 色欲香天天综合网站| 国产乱人伦av麻豆网| 久久久综合九色综合88| 中国xxx农村性视频| 日韩精品视频一区二区三区|