在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TOP1MT Antibody

TOP1MT Antibody

  • 中文名稱：
    TOP1MT兔多克隆抗體
  • 貨號：
    CSB-PA294602
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA294602(TOP1MT Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA294602(TOP1MT Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    TOP1MT
  • 別名：
    TOP1MT antibody; DNA topoisomerase I antibody; mitochondrial antibody; TOP1mt antibody; EC 5.6.2.1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human TOP1MT
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
  • 基因功能參考文獻(xiàn)：
    1. This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. PMID: 28874393
    2. Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. PMID: 24172750
    3. DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. PMID: 23261817
    4. Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. PMID: 23422507
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Type IB topoisomerase family
  • 組織特異性：
    Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29787

    OMIM: 606387

    KEGG: hsa:116447

    STRING: 9606.ENSP00000328835

    UniGene: Hs.528574



主站蜘蛛池模板： 人妻 校园 激情 另类| 亚洲熟妇无码八v在线播放| 亚洲国产成人第一天堂| 日本50岁丰满熟妇xxxx| 天天做天天爱天天综合网| 亚洲欧洲国产码专区在线观看| 亚洲不卡1卡2卡三卡入口| 男人添女人囗交做爰视频| 国产精品无码久久久久| 狠狠色综合网久久久久久| 亚洲综合熟女久久久40p| 亚洲国产日韩a在线播放| 亚洲国产精品无码观看久久| 一区二区三区无码被窝影院| 中文午夜乱理片无码| 欧美成人天天综合在线| 国产亚洲精久久久久久无码| 51国产黑色丝袜高跟鞋| 东京热毛片无码dvd一二三区| 亚洲综合另类小说色区大陆| 无码av一区二区三区无码| 人妻激情偷乱一区二区三区| 久久国产午夜精品理论片| 人与嘼av免费| 久久久久无码精品亚洲日韩| 午夜dj高清免费观看视频| 国产综合18久久久久久| 人妻丰满熟妇av无码区乱| 24小时日本在线www免费的| 亚洲综合久久成人a片红豆| 人妻无码久久一区二区三区免费| 欧美性生交大片18禁止| 好了av在线第四综合网站| 春色校园亚洲愉拍自拍| 女人被黑人狂躁c到高潮小说| 在线天堂新版最新版在线8| 99精品国产在热久久无毒| 亚洲精品久久久久avwww潮水 | 国内精品伊人久久久久av影院 | 日韩卡1卡2 卡三卡免费| 99精品国产一区二区三区a片|