在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TOP1MT Antibody

  • 中文名稱:
    TOP1MT兔多克隆抗體
  • 貨號:
    CSB-PA294602
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA294602(TOP1MT Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA294602(TOP1MT Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    TOP1MT
  • 別名:
    TOP1MT antibody; DNA topoisomerase I antibody; mitochondrial antibody; TOP1mt antibody; EC 5.6.2.1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human TOP1MT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:5-1:20
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
  • 基因功能參考文獻(xiàn):
    1. This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. PMID: 28874393
    2. Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. PMID: 24172750
    3. DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. PMID: 23261817
    4. Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. PMID: 23422507
  • 亞細(xì)胞定位:
    Mitochondrion.
  • 蛋白家族:
    Type IB topoisomerase family
  • 組織特異性:
    Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 29787

    OMIM: 606387

    KEGG: hsa:116447

    STRING: 9606.ENSP00000328835

    UniGene: Hs.528574



主站蜘蛛池模板: 天堂8а√中文在线官网| 蜜臀aⅴ国产精品久久久国产老师| 少妇的肉体k8经典| 中日韩精品卡一卡二卡3卡| 污污污污污污污网站污| 中文字幕精品亚洲无线码一区| 亚洲人成影院在线观看| 99久久精品美女高潮喷水| 久久www免费人成人片| 潮喷大喷水系列无码久久精品 | 4hu四虎永久在线观看| 宅男66lu国产在线观看| 少妇高潮惨叫久久久久电影 | 又色又爽又黄还免费毛片96下载| 长腿校花无力呻吟娇喘的视频| 欧美xxxx做受欧美| 无码吃奶揉捏奶头高潮视频| 在线视频国产网址你懂的| 国产三级a三级三级| 国精产品一品二品国精品69xx| 国产亚洲精品久久久久秋霞不卡 | 国产日产欧产精品网站| 欧美人妻日韩精品| 精品久久久久久无码人妻蜜桃| 不卡无码人妻一区二区三区| 国产人妻大战黑人20p| 亚洲中文字幕无码一区在线| 中文字日产乱码免费1~3软件 | 国产人成视频在线视频| 超碰国产天天做天天爽| 韩国主播av福利一区二区| 欧美va亚洲va在线观看| 久久免费精品国产72精品| 色噜噜亚洲男人的天堂www| 日韩电影一区二区三区| 狠狠色噜噜狠狠狠狠色综合久| 99re8精品视频热线观看| 少妇高潮太爽了在线视频| 人妻精油按摩bd高清中文字幕| 琪琪秋霞午夜av影视在线| 最新在线精品国自产拍福利|