在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TOP1MT Antibody

TOP1MT Antibody

  • 中文名稱：
    TOP1MT兔多克隆抗體
  • 貨號：
    CSB-PA125082
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA125082(TOP1MT Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA125082(TOP1MT Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    TOP1MT
  • 別名：
    TOP1MT antibody; DNA topoisomerase I antibody; mitochondrial antibody; TOP1mt antibody; EC 5.6.2.1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human TOP1MT
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:15-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
  • 基因功能參考文獻：
    1. This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. PMID: 28874393
    2. Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. PMID: 24172750
    3. DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. PMID: 23261817
    4. Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. PMID: 23422507
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Type IB topoisomerase family
  • 組織特異性：
    Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
  • 數據庫鏈接：

    HGNC: 29787

    OMIM: 606387

    KEGG: hsa:116447

    STRING: 9606.ENSP00000328835

    UniGene: Hs.528574



主站蜘蛛池模板： 免费人成在线观看视频无码| 国产精品久久久影视青草| 国产在视频线精品视频| 亚洲www啪成人一区二区麻豆| 成av人电影在线观看| 国产精品久久国产精品99盘| 人妻熟女久久久久久久| 欧美超级乱婬视频播放| 欧美成人精品手机在线| 欧美性猛交xxx嘿人猛交| 波多野结衣一区二区免费视频| 无码毛片aaa在线| 鲁一鲁一鲁一鲁一澡| 日韩欧无码一区二区三区免费不卡 | 小雪尝禁果又粗又大的视频| 亚洲国产v高清在线观看| 日产a一a区二区www| 西西人体444www高清大胆| 女人被男人爽到呻吟的视频| 亚洲精品国产福利一区二区 | 欧美交a欧美精品喷水| 日本少妇浓毛bbwbbwbbw| 无码国产精品一区二区免费16| 瑜伽裤国产一区二区三区| 伊人色综合网一区二区三区| 9lporm自拍视频区| 欧美成人猛片aaaaaaa| 成年男人裸j照无遮挡无码| 亚洲婷婷五月激情综合app| 欧美一区二区三区红桃小说| 国产毛a片啊久久久久久保和丸| 午夜电影网va内射| 曰批全过程免费视频在线观看无码| 日韩少妇内射免费播放18禁裸乳 | 亚洲精品国产美女久久久99| 国产美女久久久亚洲综合| 99视频偷窥在线精品国自产拍| 国产在线精品无码二区| 人人妻人人超人人| 人人妻人人澡人人爽欧美二区| 日韩插啊免费视频在线观看|