在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. TOP1MT Antibody

TOP1MT Antibody

  • 中文名稱：
    TOP1MT兔多克隆抗體
  • 貨號：
    CSB-PA853372LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA853372LA01HU diluted at 1:600 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) TOP1MT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    TOP1MT
  • 別名：
    TOP1MT antibody; DNA topoisomerase I antibody; mitochondrial antibody; TOP1mt antibody; EC 5.6.2.1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human DNA topoisomerase I, mitochondrial protein (270-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，TOP1MT Antibody (CSB-PA853372LA01HU)，的標記方式是Non-conjugated。對于TOP1MT Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA853372LB01HU TOP1MT Antibody, HRP conjugated ELISA
    FITC CSB-PA853372LC01HU TOP1MT Antibody, FITC conjugated
    Biotin CSB-PA853372LD01HU TOP1MT Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
  • 基因功能參考文獻：
    1. This report was the first to focus on the role of TOP1MT in tumors. We identified a new mechanism underlying TOP1MT-deficient gastric cancer (GC) metastasis and showed that TOP1MT played an important role in cancer cells. PMID: 28874393
    2. Data indicate that the different coordination geometry achieved by the two transition metal ions has an important role in modulating their efficiency as topoisomerase I inhibitors. PMID: 24172750
    3. DNA topoisomerase I stimulates BLM helicase activity on a nucleolar-relevant RNA:DNA hybrid. PMID: 23261817
    4. Data reported in this paper indicate that hTop IB does not confer to the cells radio-resistance, but the kinetic analysis of both DNA repair rate as well as colonies growth, demonstrates that the cells containing hTop IB show a more efficient rescue from IR injury. PMID: 23422507
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Type IB topoisomerase family
  • 組織特異性：
    Ubiquitous; highest in skeletal muscle, heart, brain and fetal liver.
  • 數據庫鏈接：

    HGNC: 29787

    OMIM: 606387

    KEGG: hsa:116447

    STRING: 9606.ENSP00000328835

    UniGene: Hs.528574



主站蜘蛛池模板： 无码精品国产dvd在线观看9久| 欧美老人巨大xxxx做受| 久久99精品国产麻豆不卡| 成年性生交大片免费看| 黑巨人与欧美精品一区| 少妇spa推油被扣高潮| 成人免费无码视频在线网站 | 国产精品无码久久综合| 国产小呦泬泬99精品| 精品欧美乱码久久久久久1区2区 | 国产午夜成人无码免费看不卡| 国产av影片麻豆精品传媒| 韩国和日本免费不卡在线v| 理论片午午伦夜理片影院99| 女人18毛片水最多| 精品亚洲欧美自拍| 亚洲国产成人久久一区久久| 国产白嫩护士被弄高潮| 久久精品国产精品亚洲| 特级a欧美做爰片三人交| 天下第一社区视频www日本| 中文字幕乱偷无码av先锋| 少妇做爰免费视频网站| 日本道精品一区二区三区| 18禁成年无码免费网站| 日日碰狠狠躁久久躁综合小说| 无码av天堂一区二区三区| 久久精品国产999久久久| 18级成人毛片免费观看| 东京热无码av男人的天堂| а√中文在线资源库| 国内永久福利在线视频图片| 国产乱子伦精品无码码专区 | 少妇高潮毛片色欲ava片| 久久精品国产亚洲欧美成人| 成熟老妇女毛茸茸的做性 | 色视频综合无码一区二区三区| 国产性生交xxxxx无码| 国产一区二区波多野结衣| 国产亚洲精品第一综合另类灬| √最新版天堂资源网在线下载 |