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PLXNB2

PLXNB2,即神經叢蛋白B2,別名KIAA0315、MM1、Nbla00445、PLEXB2等。它是一種跨膜受體,參與軸突導向和細胞遷移,響應于信號蛋白如血管生成素。PLXNB2的作用機制包括與血管生成素結合,激活下游的RHOA信號通路,影響細胞骨架的重組和細胞遷移。PLXNB2在神經系統發育、腫瘤發生發展、以及細胞遷移和增殖等過程中發揮重要作用。例如,它在急性髓系白血病(AML)中的過表達與不良預后相關,可能作為潛在的生物標志物和治療靶點。此外,PLXNB2還與癌癥肝轉移的形成有關,其在肝細胞中的表達增加可以促進腸癌、胰腺癌和黑色素瘤等癌癥的肝轉移。

熱銷產品

Recombinant Human Plexin-B2 (PLXNB2), partial (CSB-EP018223HUe1)

驗證數據

CSB-EP018223HUe1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PLXNB2 Antibody (CSB-PA018223ESR1HU)

驗證數據

CSB-PA018223ESR1HU

Western blot
All lanes: PLXNB2 antibody IgG at 2.39μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 205 kDa
Observed band size: 205 kDa

CSB-PA018223ESR1HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018223ESR1HU at dilution of 1:100

CSB-PA018223ESR1HU

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018223ESR1HU at dilution of 1:100

PLXNB2 Antibodies

PLXNB2 for Homo sapiens (Human)

PLXNB2 Proteins

PLXNB2 Proteins for Homo sapiens (Human)