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ACE2

血管緊張素轉(zhuǎn)化酶2(ACE2),也稱為ACEH,一種金屬蛋白酶,全長(zhǎng)805個(gè)氨基酸,是具有單一胞外催化結(jié)構(gòu)域的I型跨膜糖蛋白。ACE2組織分布具有器官特異性,主要表達(dá)于腎臟、心血管及胃腸道系統(tǒng),在正常肺組織中,Ⅰ型及Ⅱ型肺泡上皮細(xì)胞中均存在ACE2。ACE2不僅在心血管系統(tǒng)中發(fā)揮了重要的功能,而且作為SARS-CoV-2入胞的受體在肺部疾病中發(fā)揮了一定作用。研究已經(jīng)進(jìn)一步證實(shí):對(duì)于SARS-CoV-2而言,刺突蛋白(S蛋白)是介導(dǎo)病毒入侵宿主細(xì)胞的關(guān)鍵蛋白。SARS-CoV-2是通過(guò)S蛋白與ACE2結(jié)合入侵肺部細(xì)胞。ACE2與新冠病毒的RBD(受體結(jié)合結(jié)構(gòu)域)之間的親和力,比其與SARS病毒的RBD的親和力高10到20倍。隨著ACE2為SARS-CoV-2入侵人體靶點(diǎn)的揭露,阻斷病毒和 ACE2的結(jié)合成為了治療方向之一。

更多相關(guān)閱讀:
ACE2—新型冠狀病毒入侵人體的靶標(biāo)
戰(zhàn)疫時(shí)刻|再談ACE2——新冠肺炎的“導(dǎo)火線”和“滅火器”
重大發(fā)現(xiàn)|首個(gè)不依賴于ACE2的新冠病毒新受體——AXL

熱銷產(chǎn)品

Recombinant Human Angiotensin-converting enzyme 2(ACE2),partial (Active) CSB-MP866317HU

驗(yàn)證數(shù)據(jù)

SDS
CSB-MP866317HU-SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP866317HU

Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD (CSB-YP3324GMY1) at 5 μg/ml can bind human ACE2, the EC50 of human ACE2 protein is 31.80 - 44.69 ng/ml.

LSPR
CSB-MP866317HU LSPR

SARS-CoV-2 Spike protein RBD his/sumostar tag (CSB-YP3324GMY1) captured on COOH chip can bind Human ACE2 protein Fc tag (CSB-MP866317HU) with an affinity constant of 100 nM as detected by LSPR Assay.

Recombinant Macaca fascicularis Angiotensin-converting enzyme(ACE2),partial (Active) CSB-MP3414MOV

驗(yàn)證數(shù)據(jù)

SDS
CSB-MP3414MOV SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP3414MOV

Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD (CSB-MP3324GMY1b1) at 5 μg/ml can bind Cynomolgus-ACE2, the EC50 is 5.638-9.496 ng/ml.

Recombinant Paguma larvata Angiotensin-converting enzyme 2(ACE2),partial (Active) CSB-MP684964PAL

驗(yàn)證數(shù)據(jù)

SDS
CSB-MP684964PAL SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP684964PAL

Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD (CSB-MP348663HQE) at 2 μg/ml can bind Paguma larvata ACE2, the EC50 is 5.056-7.559 ng/ml.

 
CSB-MP684964PAL

Activity: Recombinant Paguma larvata ACE2 protein (CSB-MP684964PAL) enzyme activity is
Activity: Measured by its ability to cleave fluorogenic peptide substrate(Mca-Ala-Pro-Lys(Dnp)-OH), The Km is 22.84 μM.

HPLC
CSB-MP684964PAL HPLC

The purity of ACE2 was greater than 90% as determined by SEC-HPLC


ACE2 Antibodies

ACE2 for Homo sapiens (Human)

ACE2 for Rattus norvegicus (Rat)

ACE2 Proteins

ACE2 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

ACE2 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

ACE2 Proteins for Felis catus (Cat) (Felis silvestris catus)

ACE2 Proteins for Paguma larvata (Masked palm civet)

ACE2 Proteins for Bos taurus (Bovine)

ACE2 Proteins for Rattus norvegicus (Rat)

ACE2 Proteins for Pongo abelii (Sumatran orangutan)

ACE2 Proteins for Hypocrea jecorina (Trichoderma reesei)

ACE2 Proteins for Mus musculus (Mouse)

ACE2 Proteins for Homo sapiens (Human)

ACE2 ELISA Kit

ACE2 ELISA Kit for Homo sapiens (Human)

ACE2 ELISA Kit for Mus musculus (Mouse)

ACE2 ELISA Kit for Rattus norvegicus (Rat)



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