在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Angiotensin-converting enzyme 2 (Ace2), partial

Recombinant Mouse Angiotensin-converting enzyme 2 (Ace2), partial

  • 中文名稱：
    Recombinant Mouse Angiotensin-converting enzyme 2(Ace2),partial
  • 貨號：
    CSB-YP851244MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiotensin-converting enzyme 2(Ace2),partial
  • 貨號：
    CSB-EP851244MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiotensin-converting enzyme 2(Ace2),partial
  • 貨號：
    CSB-EP851244MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiotensin-converting enzyme 2(Ace2),partial
  • 貨號：
    CSB-BP851244MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Angiotensin-converting enzyme 2(Ace2),partial
  • 貨號：
    CSB-MP851244MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ace2; Angiotensin-converting enzyme 2; EC 3.4.17.23; ACE-related carboxypeptidase) [Cleaved into: Processed angiotensin-converting enzyme 2]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. Converts angiotensin I to angiotensin 1-9, a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes, and angiotensin II to angiotensin 1-7, which then acts as a beneficial vasodilator and anti-proliferation agent, counterbalancing the actions of the vasoconstrictor angiotensin II. Also removes the C-terminal residue from three other vasoactive peptides, neurotensin, kinetensin, and des-Arg bradykinin, but is not active on bradykinin. Also cleaves other biological peptides, such as apelins, casomorphins and dynorphin A. By cleavage of angiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its trafficking on the cell surface and its activity.
  • 基因功能參考文獻(xiàn)：
    1. ACE2/A1-7/Mas axis may be one of the intra-islet paracrine mechanisms of communication between alpha and beta cells. Enhancing the ACE2/A1-7 axis exerts a protective effect by ameliorating beta cell dedifferentiation. PMID: 29225087
    2. ACE2 is a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for serotonin metabolism. PMID: 29679094
    3. High ACE2 expression is associated with acute lung injury. PMID: 29990483
    4. These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway PMID: 29138810
    5. Exogenous ACE2 alters angiotensin peptide metabolism in the kidneys of Col4a3 knockout mice and attenuates the progression of Alport syndrome nephropathy. PMID: 28249676
    6. Profound augmentation of ACE2 confined to the circulation failed to ameliorate the glomerular lesions and hyperfiltration characteristic of early diabetic nephropathy. PMID: 27927599
    7. Nrf2-mediated stimulation of intrarenal Renin-Angiotensin syste, (CAE2 and MasR) gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes. PMID: 29211853
    8. In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in GSIS. These results shed light on the potential roles of ACE2 in mitochondrial metabolism, moreover, may improve our understanding of diabetes. PMID: 29128354
    9. Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage. PMID: 27612496
    10. Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2. PMID: 27806985
    11. Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala. PMID: 26767952
    12. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease. PMID: 26813885
    13. ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 and proinflammatory cytokine expression. PMID: 26498282
    14. ACE2 regulates vascular function by modulating nitric oxide release. PMID: 27070147
    15. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS axis functionality PMID: 26144375
    16. ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin resistance. PMID: 26224885
    17. a Mas receptor-mediated mechanism may stimulate pancreatic cell development PMID: 26029927
    18. ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE-mutant mice through modulation of the nephrin, NOX4 and TNF-alpha-TNFRSF1A signaling. PMID: 26245758
    19. Hydronephrosis led to an increase of ACE level and a decrease of ACE2 and Mas receptor in the heart. PMID: 25650385
    20. Overexpression of ADAM17 increases shed ACE2 and decreases cellular ACE2 levels in pancreatic islets. Whereas ADAM17 has the ability to shed ACE2, ADAM17 does not deplete ACE2 from pancreatic islets in diabetic db/db mice. PMID: 26441236
    21. ACE2 and Ang-(1-7) significantly inhibit early atherosclerotic lesion formation via protection of endothelial function and inhibition of inflammatory response. PMID: 25721616
    22. These results demonstrate a critical role for endogenous ACE2 in the adaptive beta-cell hyperinsulinemic response to High Fat feeding through regulation of beta-cell proliferation and growth. PMID: 26389599
    23. ACE2 deficiency worsened the influenza pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). PMID: 25391767
    24. Placental hypoxia and uterine artery dysfunction develop before major growth of the fetus occurs and may explain the fetal growth restricted phenotype in Ace2 knock-out pregnant mice. PMID: 25968580
    25. Beneficial effects of E2 to decrease blood pressure in ovariectomized obese females may result from stimulation of adipose ACE2. PMID: 26078188
    26. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. PMID: 24800825
    27. Whole-body deficiency of ACE2 significantly increased aortic lumen diameters and external diameters of suprarenal aortas from AngII-infused mice. PMID: 25301841
    28. Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. PMID: 25489058
    29. Partial loss of ACE2 is sufficient to enhance the susceptibility to heart disease. PMID: 24728465
    30. Suggest that the ACE2-ACE imbalance plays an important role in the pathogenesis of severe acute pancreatitis and that pancreatic ACE2 is an important factor in determining the severity of SAP. PMID: 24414175
    31. Expression of ACE2 reduced the fibrosis. PMID: 24695436
    32. Angiotensin converting enzyme 2/Ang-(1-7)/Mas axis protects brain from ischemic injury via the Nox/ROS signaling pathway, with a greater effect in older mice PMID: 24581232
    33. ACE2 deficiency promotes the development of vascular diseases associated with Ang-II-mediated vascular inflammation and activation of the JNK signalling, leading to the notion that ACE2 potentially confers protection against vascular diseases. PMID: 24193738
    34. Proximal tubular shedding of ACE2 may increase in diabetes. PMID: 24454948
    35. This study also shows that serum and urine ACE2 activity is increased in the NOD mouse model of diabetes starting at an early stage of the disease. PMID: 24400109
    36. Loss of ACE2 exacerbates AngII-mediated inflammation, myocardial injury and dysfunction in ACE2-deficient hearts via activation of the CTGF-FKN-ERK and MMP signaling. PMID: 24161906
    37. Suggest that ACE2 plays a key role in the recruitment of the renal reserve and hyperfiltration associated with diabetes. PMID: 24477684
    38. blockade of the AT1 receptor by azilsartan could enhance the activities of the ACE2/Ang-(1-7)/Mas axis and ACE2/Ang-(1-7)/AT2 receptor axis, thereby inhibiting neointimal formation. PMID: 24379178
    39. These results suggest that ACE2 plays an important role in postnatal development of the heart, and that lack of ACE2 enhances coronary artery remodeling with an increase in perivascular fibrosis and cardiac hypertrophy already around the weaning period. PMID: 23608725
    40. ACE2 has a protective role in murine renal ischemia-reperfusion injury. PMID: 23951161
    41. ACE2 was downregulated in apelin-deficient mice. Apelin, via activation of its receptor, APJ, increased ACE2 promoter activity in vitro and upregulated ACE2 expression in failing hearts in vivo. ACE2 couples the RAS to the apelin system. PMID: 24177423
    42. Unlike angiotensin-converting enzyme 2, collectrin lacks any catalytic domain. PMID: 24048198
    43. Urinary ACE2 could be a potential biomarker of increased metabolism of ANG II in diabetic kidney disease. PMID: 23761674
    44. A cardioprotective and vascular protective role is documented for ACE2 under pathological conditions. PMID: 23043153
    45. This review summarizes and discusses the structure and multiple functions of ACE2 and the relevance of this key enzyme in disease pathogenesis. PMID: 23328447
    46. ACE2 metabolizes ANG II in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH. PMID: 23392115
    47. Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice PMID: 22947377
    48. Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7). PMID: 23127535
    49. ACE2 protects against high-calorie diet-induced insulin resistance in mice. This mechanism may involve the transcriptional regulation of GLUT4 via an A1-7-dependent pathway. PMID: 22933108
    50. ACE2 deficiency impaired endothelial function in cerebral arteries from adult mice and augmented endothelial dysfunction during aging. PMID: 23160880

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Processed angiotensin-converting enzyme 2]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, cilium. Apical cell membrane.
  • 組織特異性：
    Expressed in heart, kidney and forebrain (at protein level). Expressed in the small intestine, with expression in the intestinal brush border (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 精品国际久久久久999| 粉嫩av久久一区二区三区| 三男一女吃奶添下面视频| 欧美亚洲日韩国产综合电影| 四虎国产精品永久地址入口| 久久久一本精品99久久精品88| 日本中文字幕有码在线视频| 亚洲精品无码av专区最新| 美女被啪到深处抽搐视频| 国产亚洲精品久久久久久老妇小说| 国产无遮挡裸体免费视频在线观看 | 中文字幕人妻第一区| 少妇爆乳无码专区| 99久久综合狠狠综合久久| 欧美饥渴熟妇高潮喷水| 免费网站内射红桃视频| 邻居少妇张开腿让我爽了在线观看| 免费国产a国产片高清| 人人狠狠久久亚洲综合88| 亚洲中文字幕aⅴ天堂| 中文字幕亚洲无线码在线一区| 国产高清亚洲精品视bt天堂频| 国产超碰女人任你爽| 国产精品毛片一区二区三区 | 国产日产久久高清欧美一区| 国内精品久久久久伊人av| 波多野结衣乱码中文字幕| 国产美女精品视频线免费播放软件| 婷婷五月小说| 久久99亚洲网美利坚合众国| 18禁超污无遮挡无码免费网站国产| 久久精品一区二区免费播放| 波多野结衣在线播放| 无码av免费一区二区三区a片| 无遮18禁在线永久免费观看挡 | 成在线人免费无码高潮喷水 | 亚洲日韩看片无码超清| 中文无码一区二区三区在线观看| 日本无遮挡边做边爱边摸| 天天躁日日躁狠狠躁超碰97| 亚洲乱色伦图片区小说|