在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Type-1 angiotensin II receptor-associated protein (AGTRAP)-VLPs

  • 中文名稱:
    Recombinant Human Type-1 angiotensin II receptor-associated protein(AGTRAP)
  • 貨號:
    CSB-MP744194HU
  • 規格:
  • 其他:

產品詳情

  • 基因名:
    AGTRAP
  • Uniprot No.:
  • 別名:
    AGTRAP; ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
  • 種屬:
    Homo sapiens (Human)
  • 來源:
    Mammalian cell
  • 表達區域:
    1-159aa
  • 氨基酸序列
    MELPAVNLKVILLGHWLLTTWGCIVFSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPRVSLTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAPADPFAVPEGRSQDARGY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it’s possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will default ship it in lyophilized form with normal bule ice packs. However, if you request to ship in liquid form, it needs to be shipped with dry ice, please communicate with us in advance and extra fees for dry ice and dry ice box will be charged.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store the protein at -20°C/-80°C upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
  • 基因功能參考文獻:
    1. A role for AT1 receptor-associated proteins in blood pressure regulation PMID: 25562590
    2. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. PMID: 23902639
    3. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein). PMID: 21728994
    4. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock. PMID: 21423001
    5. CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes PMID: 20541774
    6. Endogenous increases in angiotensin II during dehydration contribute to dehydration-associated sympathoexcitation. PMID: 19805740
    7. Small interfering RNA significantly attenuates angiotensin II type 1 receptor-stimulated inositol phosphate formation. PMID: 20018811
    8. cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein PMID: 11733189
    9. isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK-293 cells PMID: 14559250
    10. mRNA is detected in all human tissues; cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. PMID: 14985364
    11. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
  • 組織特異性:
    Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
  • 數據庫鏈接:

    HGNC: 13539

    OMIM: 608729

    KEGG: hsa:57085

    STRING: 9606.ENSP00000319713

    UniGene: Hs.464438



主站蜘蛛池模板: 亚洲欧美日韩综合av| 午夜精品久久久久9999| 无码精品日韩专区| 国产成人综合久久免费导航| 成人免费无码大片a毛片| 老子午夜精品无码不卡| 特殊重囗味sm在线观看无码| 欧美成人午夜性视频| 亚洲精品国偷拍自产在线观看蜜桃| 日本三级欧美三级人妇视频黑白配| 99久久er这里只有精品18| 欧美日韩精品成人网站二区| 日本少妇春药特殊按摩3| 国产精品秘入口18禁麻豆免会员| 成年午夜精品久久久精品| 免费无码成人av在线播放不卡| 国产精品久久久久aaaa| 亚洲va欧美va天堂v国产综合| 色综合久久久久综合99| 欧美天天拍在线视频| 欧美成人片一区二区三区| 丰满的人妻hd高清日本| 国产精品久久人妻无码网站蜜臀 | 亚洲无线卡一卡二| 动漫av网站免费观看| 加比勒色综合久久| 又硬又粗进去好爽免费| 精品丰满人妻无套内射| k频道国产在线观看| 国产精品成人一区二区不卡| 最新国产av无码专区亚洲| 中文字幕乱码中文乱码777 | 亚洲人禽杂交av片久久| 日本高清视频wwww色| 日韩国产成人精品视频| 色欲天天婬色婬香综合网完整版| 欧洲美熟女乱又伦av| 澳门永久av免费网站| 久久精品亚洲成在人线av麻豆| 中文字幕在线不卡精品视频99| 午夜三级a三级三点窝|