在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AGTRAP Antibody

  • 中文名稱:
    AGTRAP兔多克隆抗體
  • 貨號:
    CSB-PA001467GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AGTRAP
  • 別名:
    AGTRAP; ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human AGTRAP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
  • 基因功能參考文獻:
    1. A role for AT1 receptor-associated proteins in blood pressure regulation PMID: 25562590
    2. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. PMID: 23902639
    3. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein). PMID: 21728994
    4. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock. PMID: 21423001
    5. CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes PMID: 20541774
    6. Endogenous increases in angiotensin II during dehydration contribute to dehydration-associated sympathoexcitation. PMID: 19805740
    7. Small interfering RNA significantly attenuates angiotensin II type 1 receptor-stimulated inositol phosphate formation. PMID: 20018811
    8. cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein PMID: 11733189
    9. isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK-293 cells PMID: 14559250
    10. mRNA is detected in all human tissues; cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. PMID: 14985364
    11. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
  • 組織特異性:
    Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
  • 數據庫鏈接:

    HGNC: 13539

    OMIM: 608729

    KEGG: hsa:57085

    STRING: 9606.ENSP00000319713

    UniGene: Hs.464438



主站蜘蛛池模板: 国产精品久久久久一区二区三区 | 亚洲精品午夜无码专区| 学生精品国产在线视频| 精品无码成人网站久久久久久| 亚洲精品国产第一综合99久久| 玩弄人妻少妇精品视频| 国产av久久人人澡人人爱| 69风韵老熟女口爆吞精| 日韩精品成人一区二区三区| 国产免费毛卡片| 亚洲国产精品国语在线| 欧美成人aaaa免费全部观看| 久久综合av免费观看| 熟妇的味道hd中文字幕| 国产96在线 | 韩国| 国内精品自线在拍2020不卡| 天天干天天日夜夜操| 日韩精品人妻系列无码专区免费| 国内精品久久久久精免费| 51福利国产在线观看午夜天堂 | 忍不住的亲子中文字幕| 青草伊人久久综在合线亚洲观看| 中国少妇大p毛茸茸| 久久久亚洲精品一区二区三区浴池 | 日日碰狠狠躁久久躁96avv| 无码中文人妻在线一区| 欧美乱码卡一卡二卡三新区| 日日摸夜夜添夜夜添无码| 亚洲国产成人精品无码区软件| 体验区试看120秒啪啪免费| 长腿校花无力呻吟娇喘的视频| 精品人伦一区二区三区潘金莲| 国产在线精品一区二区三区直播| 国产精品∧v在线观看| 國产一二三内射在线看片| 丰满爆乳在线播放| av无码av在线a∨天堂app| 日日碰狠狠躁久久躁婷婷| 无码内射中文字幕岛国片| 乱子伦国产对白在线播放| 国产色婷婷亚洲99精品小说|