在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGTRAP Antibody

AGTRAP Antibody

  • 中文名稱：
    AGTRAP兔多克隆抗體
  • 貨號：
    CSB-PA964373
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA964373(AGTRAP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA964373(AGTRAP Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    AGTRAP
  • 別名：
    AGTRAP; ATRAP; Type-1 angiotensin II receptor-associated protein; AT1 receptor-associated protein
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human AGTRAP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
  • 基因功能參考文獻：
    1. A role for AT1 receptor-associated proteins in blood pressure regulation PMID: 25562590
    2. ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin resistance via regulatory effects on adipose tissue function. PMID: 23902639
    3. The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein). PMID: 21728994
    4. the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock. PMID: 21423001
    5. CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes PMID: 20541774
    6. Endogenous increases in angiotensin II during dehydration contribute to dehydration-associated sympathoexcitation. PMID: 19805740
    7. Small interfering RNA significantly attenuates angiotensin II type 1 receptor-stimulated inositol phosphate formation. PMID: 20018811
    8. cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein PMID: 11733189
    9. isolation of a novel protein, ARAP1, which promotes recycling of angiotensin(1A) to the plasma membrane in HEK-293 cells PMID: 14559250
    10. mRNA is detected in all human tissues; cellular hypertrophy in cultured rat vascular smooth muscle and renal proximal tubular cells. PMID: 14985364
    11. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
  • 組織特異性：
    Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
  • 數據庫鏈接：

    HGNC: 13539

    OMIM: 608729

    KEGG: hsa:57085

    STRING: 9606.ENSP00000319713

    UniGene: Hs.464438



主站蜘蛛池模板： 国产精品久久久久久爽爽爽| 精品一卡二卡三卡| 天天躁日日躁狠狠躁| 女同亚洲一区二区无线码| 狠狠cao2020高清视频| 无码任你躁久久久久久老妇蜜桃| 久久这里只有是精品23| 正在播放国产乱子伦最新视频| 亚洲日韩国产精品第一页一区| 亚洲欧洲日产国码无码av一 | 老太脱裤子让老头玩xxxxx| 黑色丝袜脚足国产在线看| 无码h黄肉动漫在线观看| 色婷婷亚洲精品综合影院| 无码人妻丰满熟妇奶水区码| 中文字幕乱码人妻综合二区三区| 欧美乱妇高清无乱码免费| 午夜福利影院私人爽爽| 久久久婷婷五月亚洲97色| 国产成人a人亚洲精v品无码| 国产av国片精品| 国产精品欧美一区二区三区| 538prom精品视频在线播放| 日本久久久久久久久久加勒比| 亚洲一区二区三区中文字幕在线| 4399理论片午午伦夜理片| 国产在线 | 中文| 亚洲国产人成自精在线尤物| 中文无码第3页不卡av| 国产亚洲综合欧美一区二区| 国产欧美日韩综合精品一区二区| 色欲av无码一区二区人妻| 亚洲色大网站www永久网站| 亚洲成亚洲成网| 国产在线永久视频| 波多野结衣av手机在线观看| 西西人体大胆瓣开下部毛茸茸| 亚洲精品乱码一区二区三区| 国产精品毛片在线完整版sab| 国产女人高潮叫床视频| 亚欧欧美人成视频在线|