在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Vacuolar protein sorting-associated protein 11 homolog (VPS11), partial

Recombinant Human Vacuolar protein sorting-associated protein 11 homolog (VPS11), partial

  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-YP887959HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-EP887959HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-EP887959HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-BP887959HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-MP887959HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    END1; HGNC:14583; hVPS11; PEP5; PP3476; RING finger protein 108; RNF108; Vacuolar protein sorting 11 (yeast homolog); Vacuolar protein sorting 11 (yeast); Vacuolar protein sorting 11 homolog (S. cerevisiae); Vacuolar protein sorting 11 homolog; Vacuolar protein sorting associated protein 11 homolog; Vacuolar protein sorting protein 11; Vacuolar protein sorting-associated protein 11 homolog; vps11; VPS11_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes. Involved in the retrograde Shiga toxin transport.
  • 基因功能參考文獻：
    1. Underlining the presumed pathogenic potential of VPS11 defects. PMID: 27473128
    2. our study reveals a defect in VPS11 as the underlying etiology for an autosomal recessive leukoencephalopathy disorder associated with a dysfunctional autophagy-lysosome trafficking pathway PMID: 27120463
    3. In Ashkenazi-Jewish patients, syndrome with hypomyelination, developmental delay, increasing appendicular spasticity, truncal hypotonia and acquired microcephaly is associated with VPS11 missense mutation, p.Cys846Gly. PMID: 26307567
  • 相關疾病：
    Leukodystrophy, hypomyelinating, 12 (HLD12)
  • 亞細胞定位：
    Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族：
    VPS11 family
  • 組織特異性：
    Ubiquitous. Expression was highest in heart and low in lung.
  • 數據庫鏈接：

    HGNC: 14583

    OMIM: 608549

    KEGG: hsa:55823

    UniGene: Hs.234282



主站蜘蛛池模板： 99日本精品永久免费久久 | 日本污ww视频网站| 亚洲成色www久久网站| 日本老熟妇乱| 变态另类先锋影音| 午夜一区二区亚洲福利| 亚洲精品久久一区二区三区777| 狠狠色婷婷久久综合频道日韩| 亚洲精品无码高潮喷水a片软| 亚洲美女高清aⅴ视频免费| 东京热无码国产精品| 亚洲性久久久影院| 成人区人妻精品一区二区不卡视频| 国产精品成人嫩草影院| 正在播放熟妇群老熟妇456| 亚洲日韩国产精品第一页一区| 成年丰满熟妇午夜免费视频| 亚洲中文字幕无码人在线| 亚洲色欲av无码成人专区| 日本成本人片免费网站| 曰韩免费无码av一区二区| 国模国产精品嫩模大尺度视频| 先锋影音av最新资源网| 欧美疯狂做受xxxx高潮| 久久综合狠狠色综合伊人| 亚洲制服 视频在线观看| 国产精品日本亚洲777| 性色av无码久久一区二区三区| 婷婷五月综合色视频| 国产揉捏爆乳巨胸挤奶视频| 免费无遮挡在线观看网站| 国产精品久久久久久福利| 99久久国产综合精品swag | 蜜臀av一区二区| av影音先锋最大资源网| 欧美另类精品xxxx人妖| 欧美一区二区三区成人久久片| 国产边摸边吃奶边做爽视频| 中国少妇videos呻吟| av无码一区二区三区| 无码专区 人妻系列 在线|