在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Vacuolar protein sorting-associated protein 11 homolog (VPS11), partial

Recombinant Human Vacuolar protein sorting-associated protein 11 homolog (VPS11), partial

  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-YP887959HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-EP887959HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-EP887959HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-BP887959HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人VPS11重組蛋白
  • 貨號：
    CSB-MP887959HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    END1; HGNC:14583; hVPS11; PEP5; PP3476; RING finger protein 108; RNF108; Vacuolar protein sorting 11 (yeast homolog); Vacuolar protein sorting 11 (yeast); Vacuolar protein sorting 11 homolog (S. cerevisiae); Vacuolar protein sorting 11 homolog; Vacuolar protein sorting associated protein 11 homolog; Vacuolar protein sorting protein 11; Vacuolar protein sorting-associated protein 11 homolog; vps11; VPS11_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes. Involved in the retrograde Shiga toxin transport.
  • 基因功能參考文獻：
    1. Underlining the presumed pathogenic potential of VPS11 defects. PMID: 27473128
    2. our study reveals a defect in VPS11 as the underlying etiology for an autosomal recessive leukoencephalopathy disorder associated with a dysfunctional autophagy-lysosome trafficking pathway PMID: 27120463
    3. In Ashkenazi-Jewish patients, syndrome with hypomyelination, developmental delay, increasing appendicular spasticity, truncal hypotonia and acquired microcephaly is associated with VPS11 missense mutation, p.Cys846Gly. PMID: 26307567
  • 相關疾病：
    Leukodystrophy, hypomyelinating, 12 (HLD12)
  • 亞細胞定位：
    Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族：
    VPS11 family
  • 組織特異性：
    Ubiquitous. Expression was highest in heart and low in lung.
  • 數據庫鏈接：

    HGNC: 14583

    OMIM: 608549

    KEGG: hsa:55823

    UniGene: Hs.234282



主站蜘蛛池模板： 美女又色又爽视频免费| 久久综合亚洲色一区二区三区| 女女互磨互喷水高潮les呻吟| 初尝人妻少妇中文字幕| 天堂网www在线资源中文| 77777五月色婷婷丁香视频| 高清不卡毛片免费观看| 久久激情综合狠狠爱五月| 色噜噜狠狠成人中文综合| 国产成人无码一区二区在线播放 | 国产精品免费看久久久无码| 国产精品区免费视频| 国产男女性潮高清免费网站| 强辱丰满人妻hd中文字幕| 久久综合五月丁香久久激情| 久久精品国产国产精品四凭| 顶级少妇做爰视频在线观看 | 精品人妻大屁股白浆无码| 天天躁日日躁狠狠躁2018| 日产欧美国产日韩精品| 国产作爱视频免费播放| 日本公妇乱偷中文字幕| 欧洲熟妇色xxxxx欧美老妇伦| 无码人妻aⅴ一区二区三区玉蒲团| 亚洲成av人片在线观看一区二区三区 | 欧美亚洲偷图色综合| 精品日本一区二区免费视频| 无码国产精品成人| 人人妻人人澡人人爽人人精品| 人妻中文字幕乱人伦在线| 人人妻人人澡人人爽人人精品97| 鲁一鲁av2019在线| 欧洲美女粗暴牲交免费观看| 国产乱国产乱老熟300部视频| 亚洲精品无码一二区a片| 国产高清精品软件丝瓜软件| 久久久久久人妻精品一区| 国产口爆吞精在线视频2020版| 国产色产综合色产在线视频| 狠狠亚洲色一日本高清色| 日本一区午夜艳熟免费|