在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VPS11 Antibody

  • 中文名稱:
    VPS11兔多克隆抗體
  • 貨號:
    CSB-PA887959ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA887959ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human bladder cancer using CSB-PA887959ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VPS11 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    END1 antibody; HGNC:14583 antibody; hVPS11 antibody; PEP5 antibody; PP3476 antibody; RING finger protein 108 antibody; RNF108 antibody; Vacuolar protein sorting 11 (yeast homolog) antibody; Vacuolar protein sorting 11 (yeast) antibody; Vacuolar protein sorting 11 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 11 homolog antibody; Vacuolar protein sorting associated protein 11 homolog antibody; Vacuolar protein sorting protein 11 antibody; Vacuolar protein sorting-associated protein 11 homolog antibody; vps11 antibody; VPS11_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes. Involved in the retrograde Shiga toxin transport.
  • 基因功能參考文獻:
    1. Underlining the presumed pathogenic potential of VPS11 defects. PMID: 27473128
    2. our study reveals a defect in VPS11 as the underlying etiology for an autosomal recessive leukoencephalopathy disorder associated with a dysfunctional autophagy-lysosome trafficking pathway PMID: 27120463
    3. In Ashkenazi-Jewish patients, syndrome with hypomyelination, developmental delay, increasing appendicular spasticity, truncal hypotonia and acquired microcephaly is associated with VPS11 missense mutation, p.Cys846Gly. PMID: 26307567
  • 相關疾病:
    Leukodystrophy, hypomyelinating, 12 (HLD12)
  • 亞細胞定位:
    Endosome. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族:
    VPS11 family
  • 組織特異性:
    Ubiquitous. Expression was highest in heart and low in lung.
  • 數據庫鏈接:

    HGNC: 14583

    OMIM: 608549

    KEGG: hsa:55823

    UniGene: Hs.234282



主站蜘蛛池模板: 欧美激烈精交gif动态图| 亚欧美日韩香蕉在线播放视频| 高清破外女出血av毛片| 成 人影片 免费观看在线| 无码人妻av一区二区三区波多野| 性欧美暴力猛交69hd| 亚洲欧美一区二区三区| 国色天香网www在线观看| 囯产精品一区二区三区线| 精品熟女少妇av免费观看| 西西人体大胆午夜啪啪| 亚洲欧洲日产国码在线| 国语对白做受xxxxx在| 99re在线播放| 人人澡人人透人人爽| 午夜影视啪啪免费体验区入口| 亚洲成a人v电影在线观看| 久久久国产精品| 色拍拍在线精品视频| 成人无码嫩草影院| 国产aⅴ精品一区二区三区 | 免费又黄又爽又猛的毛片| 中文字幕日韩人妻在线视频| 中国女人和老外的毛片| 精品午夜国产福利观看| 爽到高潮无码视频在线观看| www国产精品内射熟女| 亚洲国产成人久久综合下载| 国产美女露脸口爆吞精| 精品国产亚洲一区二区三区在线观看| 久久久久人妻精品一区蜜桃| 日本看片一二三区高清| 人人妻人人爽人人添夜夜欢视频| 天天狠天天透天干天天怕∴| 成人影片麻豆国产影片免费观看| 人人做人人爽久久久精品| 免免费国产aaaaa片| 精品一区二区三区免费播放| 国产超碰无码最新上传| 欧美成年网站色a| 久久这里只有精品18|