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VPS11

VPS11 is a protein in humans that is encoded by VPS11 gene. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes. Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes. Involved in the retrograde Shiga toxin transport.

VPS11 Antibodies

VPS11 for Homo sapiens (Human)

VPS11 Proteins

VPS11 Proteins for Dictyostelium discoideum (Slime mold)

VPS11 Proteins for Mus musculus (Mouse)

VPS11 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

VPS11 Proteins for Homo sapiens (Human)



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