在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 (USP20), partial

  • 中文名稱:
    人USP20重組蛋白
  • 貨號(hào):
    CSB-YP896876HU
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    人USP20重組蛋白
  • 貨號(hào):
    CSB-EP896876HU
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    人USP20重組蛋白
  • 貨號(hào):
    CSB-EP896876HU-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人USP20重組蛋白
  • 貨號(hào):
    CSB-BP896876HU
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人USP20重組蛋白
  • 貨號(hào):
    CSB-MP896876HU
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    USP20
  • Uniprot No.:
  • 別名:
    Deubiquitinating enzyme 20; hVDU2; KIAA1003; LSFR 3A; LSFR3A; pVHL interacting deubiquitinating enzyme 2; Ubiquitin carboxyl terminal hydrolase 20; Ubiquitin carboxyl-terminal hydrolase 20; ubiquitin specific peptidase 20; Ubiquitin specific processing protease 20; Ubiquitin specific protease 20; Ubiquitin thioesterase 20; Ubiquitin thiolesterase 20; Ubiquitin-specific-processing protease 20; UBP20_HUMAN; USP 20; USP20; VDU 2; VDU2; VHL interacting deubiquitinating enzyme 2; VHL-interacting deubiquitinating enzyme 2
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻(xiàn):
    1. USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on ERK3 expression. The results identify USP20 as a bona fide regulator of ERK3 stability and physiological functions. PMID: 28167606
    2. we investigated the inter-action between PKM2 and USP20. Our results suggest a new molecular pathway in cancer metabolism through the regulation of PKM2. PMID: 25708858
    3. findings reveal a dynamic regulation of USP20 by site-specific phosphorylation as well as the interdependence of signal transduction and trafficking pathways in balancing adrenergic stimulation and maintaining cellular homeostasis PMID: 25666616
    4. data establish a new function of USP20 in genome maintenance and DNA repair. PMID: 24923443
    5. Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. PMID: 22552337
    6. Our results point to USP20 as a key negative regulator of HTLV-1 Tax-induced NF-kappaB signaling. PMID: 21525354
    7. identification and description of VDU2 in human cells PMID: 12865408
    8. von Hippel-Lindau protein-interacting deubiquitinating enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha. PMID: 15776016
    9. USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface. PMID: 19424180

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.
  • 蛋白家族:
    Peptidase C19 family, USP20/USP33 subfamily
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 12619

    OMIM: 615143

    KEGG: hsa:10868

    STRING: 9606.ENSP00000313811

    UniGene: Hs.5452



主站蜘蛛池模板: 欧美亚洲国产一区二区三区| 久久国产精品波多野结衣av| 一本色道久久东京热| 日日碰狠狠躁久久躁96avv| 国产一区二区三区美女| 乱色国内精品视频在线| 国产精品老熟女露脸视频| a一区二区三区乱码在线 | 欧洲| 亚洲一卡2卡3卡4卡精品| 无码ol丝袜高跟秘书在线观看| 亚洲熟女综合一区二区三区| 狠狠综合久久综合88亚洲| 又爽又黄无遮拦成人网站| 久久丫精品久久丫| 日韩吃奶摸下aa片免费观看| 男女啪啪免费观看的网址| 高潮毛片无遮挡高清视频播放| 国产白嫩美女在线观看| 亚洲人成网站在小说| 国产在线拍揄自揄视频导航| 日本高清视频色wwwwww色| 久久久精品免费| 人人狠狠综合久久亚洲爱咲| 国产精品青青在线观看爽| 四虎国产精品永久免费网址| 久久午夜夜伦鲁鲁片免费无码| 毛片无码免费无码播放| 国产拍揄自揄免费观看| 久久精品成人免费国产片小草| 男人撕开奶罩揉吮奶头视频| 苍井空张开腿实干12次| 亚洲一区二区三区四区五区六区| 久久亚洲日韩精品一区二区三区 | 国产精品制服| 性人久久久久| 午夜精品一区二区三区免费视频| 人人妻人人澡人人爽精品欧美| 亚洲一区二区色情苍井空| 日韩欧美亚洲综合久久影院d3| 欧美野外疯狂做受xxxx高潮| 国产美女精品一区二区三区|