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  4. Recombinant Human RING finger and CCCH-type zinc finger domain-containing protein 2 (RC3H2), partial

Recombinant Human RING finger and CCCH-type zinc finger domain-containing protein 2 (RC3H2), partial

  • 中文名稱：
    人RC3H2重組蛋白
  • 貨號：
    CSB-YP884510HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RC3H2重組蛋白
  • 貨號：
    CSB-EP884510HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RC3H2重組蛋白
  • 貨號：
    CSB-EP884510HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RC3H2重組蛋白
  • 貨號：
    CSB-BP884510HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RC3H2重組蛋白
  • 貨號：
    CSB-MP884510HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RC3H2
  • Uniprot No.：
  • 別名：
    2900024N03Rik; 9430019J22Rik; D930043C02Rik; FLJ20301; FLJ20713; Membrane associated DNA binding protein; Membrane associated nucleic acid binding protein; Membrane-associated nucleic acid-binding protein; MGC52176; MNAB; OTTHUMP00000022076; OTTHUMP00000022077; OTTMUSP00000013545; OTTMUSP00000013546; Rc3h2; RC3H2_HUMAN; Ring finger and CCCH type domains 2; RING finger and CCCH type zinc finger domain containing protein 2; Ring finger and CCCH-type zinc finger domain-containing protein 2; ring finger and CCCH-type zinc finger domains 2; RING finger protein 164; RNF164; roquin-2; RP23-321B3.1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation. miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression. Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5. Able to interact with double-stranded RNA (dsRNA).
  • 基因功能參考文獻：
    1. Crystal structures, small-angle X-ray scattering, and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are different in their structures and functions. PMID: 26489670
    2. Roquin-1 and roquin-2 proteins function redundantly in mRNA degradation. PMID: 26249698
  • 亞細胞定位：
    Cytoplasm, P-body.
  • 組織特異性：
    Expressed in spleen, testis, ovary and small intestine.
  • 數據庫鏈接：

    HGNC: 21461

    OMIM: 615231

    KEGG: hsa:54542

    STRING: 9606.ENSP00000349783

    UniGene: Hs.533499



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