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RC3H2 Antibody, Biotin conjugated

  • 中文名稱:
    RC3H2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA884510LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RC3H2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RC3H2
  • 別名:
    2900024N03Rik antibody; 9430019J22Rik antibody; D930043C02Rik antibody; FLJ20301 antibody; FLJ20713 antibody; Membrane associated DNA binding protein antibody; Membrane associated nucleic acid binding protein antibody; Membrane-associated nucleic acid-binding protein antibody; MGC52176 antibody; MNAB antibody; OTTHUMP00000022076 antibody; OTTHUMP00000022077 antibody; OTTMUSP00000013545 antibody; OTTMUSP00000013546 antibody; Rc3h2 antibody; RC3H2_HUMAN antibody; Ring finger and CCCH type domains 2 antibody; RING finger and CCCH type zinc finger domain containing protein 2 antibody; Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody; ring finger and CCCH-type zinc finger domains 2 antibody; RING finger protein 164 antibody; RNF164 antibody; roquin-2 antibody; RP23-321B3.1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Roquin-2 protein (251-506AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H1, possibly leading to feedback loop regulation. miRNA-binding protein that regulates microRNA homeostasis. Enhances DICER-mediated processing of pre-MIR146a but reduces mature MIR146a levels through an increase of 3' end uridylation. Both inhibits ICOS mRNA expression and they may act together to exert the suppression. Acts as a ubiquitin E3 ligase. Pairs with E2 enzymes UBE2B, UBE2D2, UBE2E2, UBE2E3, UBE2G2, UBE2K and UBE2Q2 and produces polyubiquitin chains. Shows the strongest activity when paired with UBE2N:UBE2V1 or UBE2N:UBE2V2 E2 complexes and generate both short and long polyubiquitin chains. Involved in the ubiquitination of MAP3K5. Able to interact with double-stranded RNA (dsRNA).
  • 基因功能參考文獻:
    1. Crystal structures, small-angle X-ray scattering, and E2 profiling revealed that while the two paralogs are highly homologous, RC3H2 and RC3H1 are different in their structures and functions. PMID: 26489670
    2. Roquin-1 and roquin-2 proteins function redundantly in mRNA degradation. PMID: 26249698
  • 亞細胞定位:
    Cytoplasm, P-body.
  • 組織特異性:
    Expressed in spleen, testis, ovary and small intestine.
  • 數據庫鏈接:

    HGNC: 21461

    OMIM: 615231

    KEGG: hsa:54542

    STRING: 9606.ENSP00000349783

    UniGene: Hs.533499



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