在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Protein S100-A14 (S100A14)

  • 中文名稱(chēng):
    人S100A14重組蛋白
  • 貨號(hào):
    CSB-YP875728HUa4
  • 規(guī)格:
    ¥1500
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產(chǎn)品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    S100A14
  • Uniprot No.:
  • 別名:
    BCMP84; Protein S100-A14; S100 calcium binding protein A14; S100 calcium-binding protein A14; S100a14; S100A15; S10AE_HUMAN; S114
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度:
    Full Length
  • 來(lái)源:
    Yeast
  • 分子量:
    27.7kDa
  • 表達(dá)區(qū)域:
    1-104aa
  • 氨基酸序列
    MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 6xHis-sumostar-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.
  • 基因功能參考文獻(xiàn):
    1. S100A14 is expressed in a subset of lung adenocarcinoma, and its expression is related to certain clinicopathological parameters. Furthermore, S100A14 expression was strongly correlated with migration and invasion in lung adenocarcinoma cells. PMID: 28950283
    2. Increased S100A15 expression and decreased DNA methylation of its gene promoter region were associated with high metastasis potential and poor outcome in lung adenocarcinoma. PMID: 28498804
    3. results indicate that S100A14 may have a role in the induction of differentiation and inhibition of cell metastasis in gastric cancer. PMID: 28726786
    4. We identified a two-gene signature including KCNN4 and S100A14 which was related to recurrence in optimally debulked serous ovarian carcinoma patients PMID: 27270322
    5. Co-expression of S100A14 and S100A16 correlates with a poor prognosis in human breast cancer and promotes cancer cell invasion PMID: 25884418
    6. The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts PMID: 25502330
    7. S100A14 is expressed in epithelial-like, but not in mesenchymal-like, triple-negative breast cancer cells in vitro. PMID: 25912829
    8. Data show that the genetic variant 425G>A on the 5'-UTR of calcium-binding protein S100A14 was associated with reduced S100A14 expression in gastric cancer (GC) cells. PMID: 25266115
    9. Data indicate that S100A14 has a crucial role in EOC progression, and its overexpression is associated with poor prognosis. PMID: 24939856
    10. Data demonstrate that S100A14 is transcriptionally regulated by JunB and involved in esophageal squamous cell carcinoma cell differentiation. PMID: 24107296
    11. S100A14 interacts with S100A16 and regulates its expression in human cancer cells. PMID: 24086685
    12. Data show that S100A14 and HER2 are colocalized in plasma membrane of breast cancer tissue cells and breast cancer cell lines. PMID: 24285542
    13. High S100A14 expression is associated with metastasis of hepatocellular carcinoma. PMID: 23886191
    14. The solution structure of homodimeric S100A14 in the apo state solved by NMR PMID: 23197251
    15. that S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a p53-dependent manner. PMID: 22451655
    16. S100A14 provides a novel role in oral squamous cell carcinoma cell proliferation by inducing G1-arrest PMID: 22032898
    17. S100A14 induces cell apoptosis is partially in a RAGE-dependent manner PMID: 21559403
    18. S100A14 and S100A4 have roles in metastasis in colorectal cancer after surgery PMID: 19956863
    19. Data constitute strong evidence in support of the notion that S100A14 might function as a cancer suppressor working in the P53 pathway and play a role in esophageal carcinogenesis. PMID: 19351828

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    S-100 family
  • 組織特異性:
    Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 18901

    OMIM: 607986

    KEGG: hsa:57402

    STRING: 9606.ENSP00000340463

    UniGene: Hs.288998



主站蜘蛛池模板: 男人扒开女人双腿猛进免费视频| 韩国精品一区二区无码视频| 国产精品18久久久久久麻辣| 中文字幕欧美日韩va免费视频| 国产精成人品| 日日碰狠狠躁久久躁96| √天堂资源中文| 无码国模国产在线观看| 国产美女自慰在线观看| 久久人搡人人玩人妻精品首页| 久久97国产超碰青草| 蜜桃传媒av免费观看麻豆| 蜜臀av 国内精品久久久| 大伊香蕉精品一区视频在线 | 蜜桃视频在线观看免费视频网站www| 精品人妻大屁股白浆无码| 精品第一国产综合精品蜜芽| awww在线天堂bd资源在线| 夜夜高潮夜夜爽夜夜爱爱一区| 精品一区二区三区在线成人 | 国产成人av大片在线观看| 国产av国片精品jk制服丝袜| 无码av大香线蕉| 一区二区三区高清日本vr| 欧美大波少妇在厨房被| 性开放的女人aaa片| 少妇下蹲露大唇无遮挡| 色综合欧美亚洲国产| 国产欧美另类久久久精品不卡| 亚洲精品一区二区三区中文字幕| 免费精品国产人妻国语| 羞羞色男人的天堂| 成年女人午夜性视频| 中文字幕人妻无码一夲道| 无码gogo大胆啪啪艺术| 人妻av中文字幕一区二区三区| 又粗又黄又爽视频免费看| 国内精品九九久久精品| 久久不见久久见免费影院www日本 99久久无色码中文字幕 | 国产精品久久久天天影视香蕉| 成年男女免费视频网站|