在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Protein Hook homolog 3 (HOOK3)

Recombinant Human Protein Hook homolog 3 (HOOK3)

  • 中文名稱：
    人HOOK3重組蛋白
  • 貨號：
    CSB-YP769790HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HOOK3重組蛋白
  • 貨號：
    CSB-EP769790HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人HOOK3重組蛋白
  • 貨號：
    CSB-EP769790HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HOOK3重組蛋白
  • 貨號：
    CSB-BP769790HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HOOK3重組蛋白
  • 貨號：
    CSB-MP769790HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HOOK3
  • Uniprot No.：
  • 別名：
    FLJ31058; h-hook3; hHK3; HK3; hook3; HOOK3_HUMAN; OTTHUMP00000229200; Protein Hook homolog 3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-718
  • 氨基酸序列
    MFSVESLERA ELCESLLTWI QTFNVDAPCQ TVEDLTNGVV MAQVLQKIDP AYFDENWLNR IKTEVGDNWR LKISNLKKIL KGILDYNHEI LGQQINDFTL PDVNLIGEHS DAAELGRMLQ LILGCAVNCE QKQEYIQAIM MMEESVQHVV MTAIQELMSK ESPVSAGNDA YVDLDRQLKK TTEELNEALS AKEEIAQRCH ELDMQVAALQ EEKSSLLAEN QVLMERLNQS DSIEDPNSPA GRRHLQLQTQ LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADEAQSLK DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNTMYMQN TVSLEEELRK ANAARSQLET YKRQVVELQN RLSEESKKAD KLDFEYKRLK EKVDSLQKEK DRLRTERDSL KETIEELRCV QAQEGQLTTQ GLMPLGSQES SDSLAAEIVT PEIREKLIRL QHENKMLKLN QEGSDNEKIA LLQSLLDDAN LRKNELETEN RLVNQRLLEV QSQVEELQKS LQDQGSKAED SVLLKKKLEE HLEKLHEANN ELQKKRAIIE DLEPRFNNSS LKIEELQEAL RKKEEEMKQM EERYKKYLEK AKSVIRTLDP KQNQGAAPEI QALKNQLQER DRLFHSLEKE YEKTKSQREM EEKYIVSAWY NMGMTLHKKA AEDRLASTGS GQSFLARQRQ ATSSRRSYPG HVQPATAR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.; (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking.
  • 基因功能參考文獻：
    1. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
    2. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). PMID: 27365401
    3. results of our study identify HOOK3 as a strong candidate prognostic marker with a possible role in maintaining genomic integrity in prostate cancer, which may have potential for inclusion into clinical routine assays PMID: 26230842
    4. Results found that downregulation of Hook3 expression slows down endosomal transport and increases beta-amyloid production suggesting that Hook3 might play a critical role in pathogenic events exacerbating Alzheimer disease. PMID: 25799409
    5. Hook3 is recruited to pericentriolar satellites through interaction with pericentriolar material 1 protein PCM1. PMID: 20152126
    6. Salmonella SpiC targets the function of Hook3, a mammalian protein implicated in cellular trafficking. PMID: 12950921
    7. Hook3 interacts with a cytoplasmic domain of scavenger receptor A PMID: 17237231
    8. A fusion product between exon 11 of HOOK3 and exon 12 of RET gene was identified by 5'RACE, and the presence of chimeric HOOK3-RET protein of 88 kDa was detected by western blot analysis with an anti-RET antibody. PMID: 17639057

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Golgi apparatus.
  • 蛋白家族：
    Hook family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23576

    OMIM: 607825

    KEGG: hsa:84376

    STRING: 9606.ENSP00000305699

    UniGene: Hs.162852



主站蜘蛛池模板： 久久久久人妻精品一区蜜桃| 国产精品毛片无遮挡高清| 无码办公室丝袜ol中文字幕| 中文字幕乱码熟女人妻水蜜桃| 粉嫩av国产一区二区三区| 国产在线视频一区二区三区| 欧美性潮喷xxxxx免费视频看| 欧美日韩一区二区三区在线观看视频 | 久久天天躁夜夜躁狠狠i女人| 一区二区亚洲精品国产精华液| 国产特级毛片aaaaaa毛片| 西西人体做爰大胆gogo| 亚洲乱亚洲乱妇中文影视| 正在播放重口老熟女露脸| 免费看又黄又爽又猛的视频软件| 无套熟女av呻吟在线观看| 99久久免费国产精品| 国产成人av无码永久免费一线天| 国产精品三级av三级av三级| 免费大香伊蕉在人线国产卡 | 国产对白老熟女正在播放| 国产人妻鲁鲁一区二区| 香蕉在线精品视频在线| 久久精品国产9久久综合| 亚洲国产成人av网站| 欧洲日本一线二线三线区本庄铃| 在线精品国精品国产尤物| 亚洲精品国产美女久久久99| 四虎成人国产精品永久在线| 中文字幕av无码一二三区电影 | 免费国产在线精品一区不卡 | 欧美xxxx做受欧美人妖| 国产一区二区三区免费观看在线| 国产乱人伦av在线无码| 男女啪祼交视频| 人与禽交av在线播放| 成人爽a毛片免费网站| 清纯唯美经典一区二区| 久久久婷婷五月亚洲97色| 亚洲第一福利网站在线观看| 亚洲成a人片在线观看无码 |