在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HOOK3 Antibody

  • 中文名稱:
    HOOK3兔多克隆抗體
  • 貨號:
    CSB-PA769790LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: HOOK3 antibody at 4.9µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 84 kDa
      Observed band size: 84 kDa
    • IHC image of CSB-PA769790LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunoprecipitating HOOK3 in 293 whole cell lysate
      Lane 1: Rabbit control IgG instead of CSB-PA769790LA01HU in 293 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA769790LA01HU (6µg) + 293 whole cell lysate (500µg)
      Lane 3: 293 whole cell lysate (20µg)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HOOK3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    HOOK3
  • 別名:
    FLJ31058 antibody; h-hook3 antibody; hHK3 antibody; HK3 antibody; hook3 antibody; HOOK3_HUMAN antibody; OTTHUMP00000229200 antibody; Protein Hook homolog 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein Hook homolog 3 protein (357-455AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,HOOK3 Antibody (CSB-PA769790LA01HU),的標記方式是Non-conjugated。對于HOOK3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA769790LB01HU HOOK3 Antibody, HRP conjugated ELISA
    FITC CSB-PA769790LC01HU HOOK3 Antibody, FITC conjugated
    Biotin CSB-PA769790LD01HU HOOK3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IP
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
    IP 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.; (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking.
  • 基因功能參考文獻:
    1. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
    2. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). PMID: 27365401
    3. results of our study identify HOOK3 as a strong candidate prognostic marker with a possible role in maintaining genomic integrity in prostate cancer, which may have potential for inclusion into clinical routine assays PMID: 26230842
    4. Results found that downregulation of Hook3 expression slows down endosomal transport and increases beta-amyloid production suggesting that Hook3 might play a critical role in pathogenic events exacerbating Alzheimer disease. PMID: 25799409
    5. Hook3 is recruited to pericentriolar satellites through interaction with pericentriolar material 1 protein PCM1. PMID: 20152126
    6. Salmonella SpiC targets the function of Hook3, a mammalian protein implicated in cellular trafficking. PMID: 12950921
    7. Hook3 interacts with a cytoplasmic domain of scavenger receptor A PMID: 17237231
    8. A fusion product between exon 11 of HOOK3 and exon 12 of RET gene was identified by 5'RACE, and the presence of chimeric HOOK3-RET protein of 88 kDa was detected by western blot analysis with an anti-RET antibody. PMID: 17639057

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Golgi apparatus.
  • 蛋白家族:
    Hook family
  • 數據庫鏈接:

    HGNC: 23576

    OMIM: 607825

    KEGG: hsa:84376

    STRING: 9606.ENSP00000305699

    UniGene: Hs.162852



主站蜘蛛池模板: 国产精品992tv在线观看| 妺妺窝人体色www在线观看| 小宝极品内射国产在线| 日本熟妇浓毛hdsex| 久久久久久人妻一区二区三区| 手机看片福利一区二区三区| 蜜臀亚洲精品国产aⅴ综合第一| 少妇愉情理伦片丰满丰满午夜| 欧美日韩无套内射另类| 亚洲精品成人网线在线播放va| 又黄又湿免费高清视频| 丰满少妇熟女高潮流白浆| 少妇被爽到高潮喷水久久欧美精品| 丁香五香天堂网| 男人添女人下部高潮视频| 久久不见久久见免费视频6无删减| 久久人人爽人人爽爽久久小说| 成人无码a∨电影免费| 99久久99久久免费精品蜜桃| 国产午夜福利片在线观看| 国模无码一区二区三区| 好了av四色综合无码久久| 国产与黑人在线播放| 久久久97丨国产人妻熟女| 蜜桃视频无码区在线观看| 欧美性生 活18~19| 无码av中文字幕免费放| 久久精品国产只有精品96| 拍摄av现场失控高潮数次| 国产伦精品一区二区三区免费迷| 国产尤物av尤物在线看| 国产美女被遭强高潮网站下载| 国产成人愉拍免费视频| 少妇裸体性生交| 国内精品人妻久久毛片app| 吃奶摸下的激烈视频| 国产成人亚洲精品无码车a| 亚洲欭美日韩颜射在线| 中出内射颜射骚妇| 日本丰满熟妇videossex| 嫩草国产福利视频一区二区|