在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HOOK3 Antibody

  • 中文名稱:
    HOOK3兔多克隆抗體
  • 貨號:
    CSB-PA010642GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HOOK3
  • 別名:
    FLJ31058 antibody; h-hook3 antibody; hHK3 antibody; HK3 antibody; hook3 antibody; HOOK3_HUMAN antibody; OTTHUMP00000229200 antibody; Protein Hook homolog 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HOOK3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.; (Microbial infection) May serve as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking.
  • 基因功能參考文獻:
    1. This work reveals the structural details of Hook3's interaction with dynein and offers insight into how cargo adaptors form processive dynein-dynactin motor complexes. PMID: 27482052
    2. Single-molecule motility assays using total internal reflection fluorescence microscopy indicate that both Hook1 and Hook3 effectively activate cytoplasmic dynein, inducing longer run lengths and higher velocities than the previously characterized dynein activator bicaudal D2 (BICD2). PMID: 27365401
    3. results of our study identify HOOK3 as a strong candidate prognostic marker with a possible role in maintaining genomic integrity in prostate cancer, which may have potential for inclusion into clinical routine assays PMID: 26230842
    4. Results found that downregulation of Hook3 expression slows down endosomal transport and increases beta-amyloid production suggesting that Hook3 might play a critical role in pathogenic events exacerbating Alzheimer disease. PMID: 25799409
    5. Hook3 is recruited to pericentriolar satellites through interaction with pericentriolar material 1 protein PCM1. PMID: 20152126
    6. Salmonella SpiC targets the function of Hook3, a mammalian protein implicated in cellular trafficking. PMID: 12950921
    7. Hook3 interacts with a cytoplasmic domain of scavenger receptor A PMID: 17237231
    8. A fusion product between exon 11 of HOOK3 and exon 12 of RET gene was identified by 5'RACE, and the presence of chimeric HOOK3-RET protein of 88 kDa was detected by western blot analysis with an anti-RET antibody. PMID: 17639057

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Golgi apparatus.
  • 蛋白家族:
    Hook family
  • 數據庫鏈接:

    HGNC: 23576

    OMIM: 607825

    KEGG: hsa:84376

    STRING: 9606.ENSP00000305699

    UniGene: Hs.162852



主站蜘蛛池模板: 六十熟妇乱子伦视频| 久久精品无码一区二区无码| 拍国产乱人伦偷精品视频| 内射小寡妇无码| 福利姬国产精品一区在线| 国产亚洲精品久久久久久牛牛| 国产精品久久福利网站| 日本亚洲国产一区二区三区| 午夜激成人免费视频在线观看 | 黄网在线观看免费网站| 水蜜桃av无码| 伊人精品成人久久综合| 亚洲精品99久久久久久欧美版| 久久综合九色综合欧美98| 成人区精品一区二区婷婷| 欧美乱妇xxxxxbbbbb| 亚洲色精品三区二区一区| 亚洲欧洲日产国码无码久久99| 日产无码中文字幕av| 国产公开久久人人97超碰| 久久av无码精品人妻出轨| 国产女同疯狂作爱系列| 奇米777四色在线精品| 国产精品福利一区二区久久| 国产精品成熟老女人| 又粗又硬整进去好爽视频| 日本一卡2卡3卡4卡5卡精品视频| 色香欲综合成人免费视频 | 内射人妻少妇无码一本一道| 国内精品伊人久久久久777| 亚洲综合最新无码专区| 日韩亚洲国产主播在线不卡| 99精品久久毛片a片| 中文字幕久久综合伊人| 九九99无码精品视频在线观看| 免费观看黄网站| 色资源av中文无码先锋| 东京热加勒比视频一区| 中文字幕亚洲综合久久菠萝蜜| 毛茸茸性xxxx毛茸茸毛茸茸| 国产主播av福利精品一区|