在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human N (4)- (beta-N-acetylglucosaminyl)-L-asparaginase (AGA)

  • 中文名稱:
    Recombinant Human N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase(AGA)
  • 貨號:
    CSB-YP001423HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase(AGA)
  • 貨號:
    CSB-EP001423HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase(AGA)
  • 貨號:
    CSB-BP001423HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase(AGA)
  • 貨號:
    CSB-MP001423HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    AGA
  • Uniprot No.:
  • 別名:
    Aga; AGU; Aspartylglucosaminidase; Aspartylglucosylamine deaspartylase; Aspartylglycosaminuria; ASPG_HUMAN; ASRG; GA; Glycosylasparaginase; Glycosylasparaginase beta chain; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; N4 (N acetyl beta glucosaminyl) L asparagine amidase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    24-205
  • 氨基酸序列
    SSPLPLV VNTWPFKNAT EAAWRALASG GSALDAVESG CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLE HTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG PYKPPGILKQ DIPIHKETED DRGHD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
  • 基因功能參考文獻:
    1. 1.8A resolution crystal structure of mature G172D mutant of a model missense GA corresponding to a Canadian aspartylglucosaminuria allele; studied the effect of its single amino acid change on substrate processing PMID: 28457719
    2. We show that gene-silenced cells show specifically reduced AGA activity and store globotriaosylceramide. In gene-silenced cells, release of the neurotransmitter acetylcholine is significantly reduced, demonstrating that this model may be used to study specific neuronal functions such as neurotransmitter release in Fabry disease PMID: 27471012
    3. study reports 2 novel aspartylglucosaminidase gene mutations, one in Qatari twins with an early, perinatal presentation not previously described for aspartylglucosaminuria and the other in 3 Turkish children with newly diagnosed aspartylglucosaminuria and a more classical disease course PMID: 23271757
    4. [review] Natural killer (NK) cell tumors, subtypes of myeloid leukemias and T-cell lymphomas respond to ASNase; ovarian carcinomas and other solid tumors have been proposed as additional targets for ASNase, with a potential role for glutaminase. activity. PMID: 21854356
    5. Molecular mechanism for the autoproteolytic activation of aspartylglucosaminidase. PMID: 14616088
    6. A new point mutation, c.44T>G, found in a Finnish compound heterozygote causes a L15R AA substitution in the signal sequence of the AGA enzyme, affecting AGA translocation by altering a critical hydrophobic core structure in the signal sequence. PMID: 15365992
    7. aspartylglucosaminidase may have a role in development of congenital disorders of glycosylation type I PMID: 16435229
    8. The amino acid substitutions in aspartylglucosaminidase responsible for aspartylglucosaminuria were classified and divided in three groups. PMID: 18992224
    9. Increased AGA plasma activity, although a consistent finding in congenital disorders of glycosylation patients, is not specific to this group of disorders. PMID: 19100247

    顯示更多

    收起更多

  • 相關疾病:
    Aspartylglucosaminuria (AGU)
  • 亞細胞定位:
    Lysosome.
  • 蛋白家族:
    Ntn-hydrolase family
  • 數據庫鏈接:

    HGNC: 318

    OMIM: 208400

    KEGG: hsa:175

    STRING: 9606.ENSP00000264595

    UniGene: Hs.207776



主站蜘蛛池模板: 国产精品av在线| 夜精品一区二区无码a片| 国产日本精品视频在线观看| 国产高清av喷水白丝护士| 国产无吗一区二区三区在线欢 | 中文字幕精品久久久久人妻红杏1| 五级黄高潮片90分钟视频| 亚洲日韩成人性av网站| 欧美精品黑人粗大破除| 国产欧美精品一区二区色综合| 国産精品久久久久久久| 人人玩人人添人人澡超碰偷拍| 少妇被又大又粗猛烈进出视频| 国产情侣一区二区| 看全色黄大色大片免费久久| 久久青青草原国产毛片| 77se77亚洲欧美在线| 欧洲亚洲色视频综合在线| 中文字幕乱码亚洲无线三区| 亚洲中文字幕无码一区在线| 在线岛国片免费无码av| 老湿机香蕉久久久久久| 人妻va精品va欧美va| 欧美成人精品第一区二区三区| 亚洲欧美色αv在线影视| 国产成人无码精品久久涩吧| 欧美人与牲动交xxxx| 久久人人爽人人爽人人片av麻烦 | 国产色秀视频在线播放| 亚洲精品一区二区三区在线 | 久久66热人妻偷产精品| 无码精品国产va在线观看| 福利姬液液酱喷水| 拍国产乱人伦偷精品视频| 国内精品久久久久久影院8f| 日本护士毛茸茸| 国产人与禽zoz0性伦| 国产精品女同一区二区在线| 我的性奴的肉玩具1一17心奴| 丰满少妇被猛烈进入高清播放| 欧洲av成本人在线观看免费|