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  4. Recombinant Human Laminin subunit alpha-4 (LAMA4), partial

Recombinant Human Laminin subunit alpha-4 (LAMA4), partial

  • 中文名稱：
    人LAMA4重組蛋白
  • 貨號：
    CSB-YP621948HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LAMA4重組蛋白
  • 貨號：
    CSB-EP621948HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LAMA4重組蛋白
  • 貨號：
    CSB-EP621948HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LAMA4重組蛋白
  • 貨號：
    CSB-BP621948HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LAMA4重組蛋白
  • 貨號：
    CSB-MP621948HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CMD1JJ; DKFZp686D23145 ; LAMA3 ; LAMA3, formerly; LAMA4 1; LAMA4; LAMA4*-1; LAMA4_HUMAN; Laminin alpha 4; Laminin alpha 4 chain; Laminin subunit alpha 4 precursor; Laminin subunit alpha-4; Laminin-14 subunit alpha; Laminin-8 subunit alpha; Laminin-9 subunit alpha
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻：
    1. High LAMA4 expression is associated with gastric cancer. PMID: 30015861
    2. Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) PMID: 27614294
    3. highlight MCAM and LAMA4 as prime candidates for RCC prognosis and therapeutic targeting PMID: 26921326
    4. LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. PMID: 26295200
    5. LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 and ERK activation. PMID: 26059342
    6. Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia. PMID: 25676580
    7. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146). PMID: 24951930
    8. Data from experiment with peptide fragments suggest laminin alpha4 (and laminin alpha5) may be part of host defense response and may protect tissues from invading pathogens. PMID: 20433883
    9. Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
    10. Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. PMID: 12445830
    11. The G domain of laminin alpha4 chain is a specific, high affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, with alpha6beta1, cooperatively mediate endothelial cell-alpha4 laminin interaction & blood vessel development. PMID: 12454288
    12. The alpha4 laminin subunit regulates vascular endothelium cell survival. PMID: 14980521
    13. laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4. PMID: 15086543
    14. Downregulation of laminin alpha4 chain expression inhibits glioma invasion PMID: 15915502
    15. laminin isoform changes are associated with brain tumor invasion and angiogenesis [review] PMID: 16146715
    16. This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin. PMID: 16824487
    17. alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo. PMID: 17533363
    18. 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure. PMID: 17646580
    19. LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression. PMID: 18084776
    20. Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, suggesting that tumor cells could utilize laminin-411 in their invasive behavior PMID: 18496706
    21. LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells PMID: 19048114

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  • 相關疾病：
    Cardiomyopathy, dilated 1JJ (CMD1JJ)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 組織特異性：
    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn t
  • 數據庫鏈接：

    HGNC: 6484

    OMIM: 600133

    KEGG: hsa:3910

    STRING: 9606.ENSP00000230538

    UniGene: Hs.654572



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