在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LAMA4 Antibody

  • 中文名稱:
    LAMA4兔多克隆抗體
  • 貨號:
    CSB-PA003134
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 293 cells using Laminin α-4 Polyclonal Antibody
    • Western Blot analysis of COLO 293 cells using Laminin α-4 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CMD1JJ antibody; DKFZp686D23145 antibody; LAMA3 antibody; LAMA3, formerly antibody; LAMA4 1 antibody; LAMA4 antibody; LAMA4*-1 antibody; LAMA4_HUMAN antibody; Laminin alpha 4 antibody; Laminin alpha 4 chain antibody; Laminin subunit alpha 4 precursor antibody; Laminin subunit alpha-4 antibody; Laminin-14 subunit alpha antibody; Laminin-8 subunit alpha antibody; Laminin-9 subunit alpha antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Laminin α-4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻:
    1. High LAMA4 expression is associated with gastric cancer. PMID: 30015861
    2. Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) PMID: 27614294
    3. highlight MCAM and LAMA4 as prime candidates for RCC prognosis and therapeutic targeting PMID: 26921326
    4. LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. PMID: 26295200
    5. LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 and ERK activation. PMID: 26059342
    6. Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia. PMID: 25676580
    7. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146). PMID: 24951930
    8. Data from experiment with peptide fragments suggest laminin alpha4 (and laminin alpha5) may be part of host defense response and may protect tissues from invading pathogens. PMID: 20433883
    9. Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
    10. Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. PMID: 12445830
    11. The G domain of laminin alpha4 chain is a specific, high affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, with alpha6beta1, cooperatively mediate endothelial cell-alpha4 laminin interaction & blood vessel development. PMID: 12454288
    12. The alpha4 laminin subunit regulates vascular endothelium cell survival. PMID: 14980521
    13. laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4. PMID: 15086543
    14. Downregulation of laminin alpha4 chain expression inhibits glioma invasion PMID: 15915502
    15. laminin isoform changes are associated with brain tumor invasion and angiogenesis [review] PMID: 16146715
    16. This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin. PMID: 16824487
    17. alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo. PMID: 17533363
    18. 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure. PMID: 17646580
    19. LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression. PMID: 18084776
    20. Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, suggesting that tumor cells could utilize laminin-411 in their invasive behavior PMID: 18496706
    21. LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells PMID: 19048114

    顯示更多

    收起更多

  • 相關疾病:
    Cardiomyopathy, dilated 1JJ (CMD1JJ)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 組織特異性:
    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn t
  • 數據庫鏈接:

    HGNC: 6484

    OMIM: 600133

    KEGG: hsa:3910

    STRING: 9606.ENSP00000230538

    UniGene: Hs.654572



主站蜘蛛池模板: 欧洲一卡2卡3卡4卡乱码视频 | 凸凹人妻人人澡人人添| 新狼窝色av性久久久久久| 久久 国产 尿 小便 嘘嘘| 免费国产成人高清在线观看网站| 羞涩的丰满人妻40p| 国产精品久久久久久人妻精品| 小说区 图片区色 综合区| 永久免费无码日韩视频| 大桥未久亚洲一区二区| 免费国产午夜视频在线观看 | 亚洲精品久久久久久| 久久精品国产第一区二区三区| 18禁美女黄网站色大片在线| 九九九精品成人免费视频小说| 麻豆传传媒久久久爱| 日日噜噜噜夜夜爽爽狠狠视频| 两个美女裸体舌吻互扒内裤| 一区二区三区毛aaaa片特级| 国产精品二区一区二区aⅴ污介绍| 无套内谢的新婚少妇国语播放| 色综合久久88色综合天天| 国内精品乱码卡一卡2卡麻豆| 国产人妻精品一区二区三首| 欧美亚洲国产一区二区三区| 老司机午夜福利视频| 天天澡日日澡狠狠欧美老妇| 天堂www中文资源| 国产午夜精品一区二区三区不卡| 亚洲国产精品特色大片观看完整版| 久久97久久97精品免视看秋霞| 亚洲欧洲美洲在线观看| 一道久久爱综合久久爱| 欧美成人秋霞久久aa片| 人妻少妇精品无码专区芭乐视网| 男人边吃奶边做好爽免费视频| 国产亚洲精品久久久久久牛牛 | 亚洲第一在线综合网站| 国产农村老太xxxxhdxx| 日本在线看片免费人成视频1000| 亚洲精品国产自在久久|