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  4. Human Laminin subunit alpha-4(LAMA4) ELISA kit

Human Laminin subunit alpha-4(LAMA4) ELISA kit

  • 中文名稱：
    人層粘連蛋白亞基α-4(LAMA4)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL012728HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人層粘連蛋白亞基α-4(LAMA4)酶聯(lián)免疫試劑盒（CSB-EL012728HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的LAMA4含量。LAMA4是一個重要靶點。它是層粘連蛋白α4亞基，在細胞黏附、遷移和組織發(fā)育等過程有重要作用。研究機制方面，主要聚焦其與細胞表面受體相互作用調(diào)節(jié)細胞行為，在腫瘤、心血管疾病等病理機制研究中有潛在意義。試劑盒檢測范圍為23.5 pg/mL-1500 pg/mL，適用于多種科研場景，包括探究心血管疾病、腫瘤轉(zhuǎn)移或纖維化疾病中細胞外基質(zhì)的動態(tài)變化，分析組織再生過程中LAMA4的表達調(diào)控機制，以及評估實驗?zāi)Ｐ椭谢|(zhì)重塑相關(guān)分子通路的功能。為體外研究LAMA4在生理病理過程中的作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CMD1JJ ELISA Kit; DKFZp686D23145 ELISA Kit; LAMA3 ELISA Kit; LAMA3, formerly ELISA Kit; LAMA4 1 ELISA Kit; LAMA4 ELISA Kit; LAMA4*-1 ELISA Kit; LAMA4_HUMAN ELISA Kit; Laminin alpha 4 ELISA Kit; Laminin alpha 4 chain ELISA Kit; Laminin subunit alpha 4 precursor ELISA Kit; Laminin subunit alpha-4 ELISA Kit; Laminin-14 subunit alpha ELISA Kit; Laminin-8 subunit alpha ELISA Kit; Laminin-9 subunit alpha ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    23.5 pg/mL-1500 pg/mL
  • 靈敏度：
    5.86 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human LAMA4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:20 Average % 95
    Range % 88-99
    1:40 Average % 104
    Range % 98-108
    1:80 Average % 90
    Range % 85-94
    1:160 Average % 99
    Range % 90-103
  • 回收率：
    The recovery of human LAMA4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 92 84-97
    EDTA plasma (n=4) 101 93-104
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1500 2.673 2.586 2.630 2.535
    750 2.180 2.145 2.163 2.068
    375 1.786 1.712 1.749 1.654
    187.5 1.201 1.239 1.220 1.125
    94 0.653 0.648 0.651 0.556
    47 0.415 0.422 0.419 0.324
    23.5 0.252 0.263 0.258 0.163
    0 0.093 0.097 0.095 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻：
    1. High LAMA4 expression is associated with gastric cancer. PMID: 30015861
    2. Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) PMID: 27614294
    3. highlight MCAM and LAMA4 as prime candidates for RCC prognosis and therapeutic targeting PMID: 26921326
    4. LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. PMID: 26295200
    5. LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 and ERK activation. PMID: 26059342
    6. Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia. PMID: 25676580
    7. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146). PMID: 24951930
    8. Data from experiment with peptide fragments suggest laminin alpha4 (and laminin alpha5) may be part of host defense response and may protect tissues from invading pathogens. PMID: 20433883
    9. Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
    10. Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. PMID: 12445830
    11. The G domain of laminin alpha4 chain is a specific, high affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, with alpha6beta1, cooperatively mediate endothelial cell-alpha4 laminin interaction & blood vessel development. PMID: 12454288
    12. The alpha4 laminin subunit regulates vascular endothelium cell survival. PMID: 14980521
    13. laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4. PMID: 15086543
    14. Downregulation of laminin alpha4 chain expression inhibits glioma invasion PMID: 15915502
    15. laminin isoform changes are associated with brain tumor invasion and angiogenesis [review] PMID: 16146715
    16. This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin. PMID: 16824487
    17. alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo. PMID: 17533363
    18. 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure. PMID: 17646580
    19. LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression. PMID: 18084776
    20. Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, suggesting that tumor cells could utilize laminin-411 in their invasive behavior PMID: 18496706
    21. LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells PMID: 19048114

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  • 相關(guān)疾病：
    Cardiomyopathy, dilated 1JJ (CMD1JJ)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 組織特異性：
    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn t
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6484

    OMIM: 600133

    KEGG: hsa:3910

    STRING: 9606.ENSP00000230538

    UniGene: Hs.654572



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