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LAMA4 Antibody

  • 中文名稱:
    LAMA4兔多克隆抗體
  • 貨號:
    CSB-PA915894
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from COLO cells and 293 cells, using LAMA4 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human heart tissue using LAMA4 antibody.
    • Immunofluorescence analysis of NIH/3T3 cells, using LAMA4 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) LAMA4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human LAMA4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻(xiàn):
    1. High LAMA4 expression is associated with gastric cancer. PMID: 30015861
    2. Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) PMID: 27614294
    3. highlight MCAM and LAMA4 as prime candidates for RCC prognosis and therapeutic targeting PMID: 26921326
    4. LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. PMID: 26295200
    5. LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 and ERK activation. PMID: 26059342
    6. Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia. PMID: 25676580
    7. Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146). PMID: 24951930
    8. Data from experiment with peptide fragments suggest laminin alpha4 (and laminin alpha5) may be part of host defense response and may protect tissues from invading pathogens. PMID: 20433883
    9. Laminins with alpha1, alpha4, and alpha5 chains are compared to determine laminin isoform-specific promotion of adhesion and migration of human bone marrow progenitor cells. PMID: 12393739
    10. Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. PMID: 12445830
    11. The G domain of laminin alpha4 chain is a specific, high affinity ligand for alphavbeta3 & alpha3beta1 integrin heterodimers. These integrins, with alpha6beta1, cooperatively mediate endothelial cell-alpha4 laminin interaction & blood vessel development. PMID: 12454288
    12. The alpha4 laminin subunit regulates vascular endothelium cell survival. PMID: 14980521
    13. laminin alpha4 LG4 module may play an important role in cell adhesion and/or vessel wall formation in the skin by interacting with syndecan-2 and/or -4. PMID: 15086543
    14. Downregulation of laminin alpha4 chain expression inhibits glioma invasion PMID: 15915502
    15. laminin isoform changes are associated with brain tumor invasion and angiogenesis [review] PMID: 16146715
    16. This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin. PMID: 16824487
    17. alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo. PMID: 17533363
    18. 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure. PMID: 17646580
    19. LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression. PMID: 18084776
    20. Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, suggesting that tumor cells could utilize laminin-411 in their invasive behavior PMID: 18496706
    21. LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells PMID: 19048114

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  • 相關(guān)疾病:
    Cardiomyopathy, dilated 1JJ (CMD1JJ)
  • 亞細(xì)胞定位:
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 組織特異性:
    In adult, strong expression in heart, lung, ovary small and large intestines, placenta, liver; weak or no expression in skeletal muscle, kidney, pancreas, testis, prostate, brain. High expression in fetal lung and kidney. Expression in fetal and newborn t
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6484

    OMIM: 600133

    KEGG: hsa:3910

    STRING: 9606.ENSP00000230538

    UniGene: Hs.654572



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