在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Fanconi anemia group F protein (FANCF)

Recombinant Human Fanconi anemia group F protein (FANCF)

  • 中文名稱：
    人FANCF重組蛋白
  • 貨號：
    CSB-YP873614HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人FANCF重組蛋白
  • 貨號：
    CSB-EP873614HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人FANCF重組蛋白
  • 貨號：
    CSB-EP873614HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人FANCF重組蛋白
  • 貨號：
    CSB-BP873614HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人FANCF重組蛋白
  • 貨號：
    CSB-MP873614HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    FANCF
  • Uniprot No.：
  • 別名：
    A730016A17; FACF; FAF; FANCF; FANCF_HUMAN; Fanconi anemia complementation group F; Fanconi anemia group F protein; MGC126856; Protein FACF; RGD1561456
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-374
  • 氨基酸序列
    MESLLQHLDR FSELLAVSST TYVSTWDPAT VRRALQWARY LRHIHRRFGR HGPIRTALER RLHNQWRQEG GFGRGPVPGL ANFQALGHCD VLLSLRLLEN RALGDAARYH LVQQLFPGPG VRDADEETLQ ESLARLARRR SAVHMLRFNG YRENPNLQED SLMKTQAELL LERLQEVGKA EAERPARFLS SLWERLPQNN FLKVIAVALL QPPLSRRPQE ELEPGIHKSP GEGSQVLVHW LLGNSEVFAA FCRALPAGLL TLVTSRHPAL SPVYLGLLTD WGQRLHYDLQ KGIWVGTESQ DVPWEELHNR FQSLCQAPPP LKDKVLTALE TCKAQDGDFE VPGLSIWTDL LLALRSGAFR KRQVLGLSAG LSSV
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
  • 基因功能參考文獻：
    1. LOH in FA genes appears to be a common feature of head and neck squamous cell carcinomas development seen here in 57% of patients and other mutation types may increase this mutation frequency. We suggest larger patient cohorts would be needed to test the observed association of LOH in FANCF and patient survival comprehensively PMID: 28440438
    2. we report three patients who illustrate the clinical variability within the FA-F group. This analysis suggests a more severe phenotype for those with the common c.484_485delCT mutation. PMID: 27714961
    3. CpG island methylation of FANCF gene promoter region is strongly associated with the susceptibility and clinicopathologic features of epithelial ovarian cancer. PMID: 26507869
    4. careful examination of three electively aborted fetuses in one family and one affected girl in the other indicated an association of the FANCF loss-of-function mutation with a severe phenotype characterized by multiple malformations PMID: 26033879
    5. Data suggest that the Fanconi anemia group F protein/BRCA1/2 proteins pathway may be a new target to reverse adriamycin (ADR) resistance in leukemia treatment. PMID: 24996439
    6. Silencing of FANCF enhanced the antiproliferative effect of ADM in OVCAR3 cells. PMID: 23440494
    7. FANCF methylation is a rare event in Japanese primary invasive breast cancer. PMID: 19813073
    8. Data identify the gene encoding Fanconi F (FANCF) as an ICSBP target gene. PMID: 19801548
    9. inactivation of the FANC-BRCA pathway is relatively common in solid tumors and may be related to tobacco and alcohol exposure and survival PMID: 14647419
    10. Inactivation of genes in the FA-BRCA pathway by epigenetic alterations have been found in a high proportion of cervix cancer patients, suggesting a major role for this pathway in the development of cervical cancer. PMID: 15126331
    11. FANCF acts as a flexible adaptor protein that plays a key role in the proper assembly of the FA core complex. PMID: 15262960
    12. results showed that FANCF methylation regulates the expression of FANCF at both mRNA and protein levels; methylation-induced inactivation of FANCF plays an important role in the occurrence of ovarian cancers via disrupting the FA-BRCA pathway PMID: 16418574
    13. human FANCF protein has specific structural components that function in the assembly of a DNA damage signaling complex PMID: 17082180
    14. FANCF methylation was rare in breast tumors PMID: 17932744
    15. This study does not support methylation-dependent silencing of FANCF as a mechanism of sensitisation to platinum-based chemotherapy in ovarian cancer. PMID: 18414472

    顯示更多

    收起更多

  • 相關疾病：
    Fanconi anemia complementation group F (FANCF)
  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 3587

    OMIM: 603467

    KEGG: hsa:2188

    STRING: 9606.ENSP00000330875

    UniGene: Hs.632151



主站蜘蛛池模板： 国产亚洲精品无码成人| 日韩视频 中文字幕 视频一区| 一本大道东京热无码| 亚洲啪av永久无码精品放毛片| 亚洲精品久久久久久久蜜臀老牛| 亚洲日韩欧美国产另类综合| 亚洲色欲色欲www在线看| 色偷偷av亚洲男人的天堂| 国产爆乳无码视频在线观看3| 国产超碰无码最新上传| 最大胆裸体人体牲交免费| 人妻少妇久久久久久97人妻| 日韩一区二区在线观看视频| 亚洲国产午夜精品理论片妓女| 精品久久久久久久国产潘金莲| 99精品欧美一区二区三区| 欧美性猛交xxxx免费看| 人妻护士在线波多野结衣| 欧美精品无码久久久久久| 亚洲午夜未满十八勿入网站| 欧美三级欧美成人高清| 欧美综合乱图图区乱图图区| 久久精晶国产99久久6| 成在人线av无码免费| 亚洲另类无码专区丝袜| 无码精品人妻一区二区三区98| 亚洲女同一区二区| 国产精品99久久久久久www| 337p粉嫩日本欧洲亚福利| 国产98在线 | 欧美| 乱妇乱女熟妇熟女网站| 加比勒色综合久久| 久久99亚洲精品久久69| 亚洲国产精品第一区二区| 日产亚洲一区二区三区| 久久久噜噜噜久久熟女色| 无码视频一区二区三区| 日本妇人成熟免费| 丰满多毛的陰户视频| 国产高清在线精品二区| 日本肥老妇色xxxxx日本老妇|