在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human F-box only protein 3 (FBXO3)

  • 中文名稱:
    人FBXO3重組蛋白
  • 貨號:
    CSB-EP892132HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人FBXO3重組蛋白
  • 貨號:
    CSB-EP892132HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人FBXO3重組蛋白
  • 貨號:
    CSB-BP892132HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人FBXO3重組蛋白
  • 貨號:
    CSB-MP892132HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Name:FBXO3 Synonyms:FBX3
  • Uniprot No.:
  • 別名:
    F Box G - Domain 3; F box only protein 3; F box protein 3; F box protein FBX3; F-box only protein 3; FBA; FBX3; FBX3_HUMAN; FBXO3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-471
  • 氨基酸序列
    MAAMETETAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI IGATFTDWFT SYVKNVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY EEMEEEEEEE EEEDEDDDSA DMDESDEDDE EERRRRVFDV PIRRRRCSRL F
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 基因功能參考文獻:
    1. we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866
    2. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
    3. Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664
    4. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    5. controls TRAF adaptor stability to regulate inflammation PMID: 23542741
    6. Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
  • 數據庫鏈接:

    HGNC: 13582

    OMIM: 609089

    KEGG: hsa:26273

    STRING: 9606.ENSP00000265651

    UniGene: Hs.406787



主站蜘蛛池模板: 亚洲综合另类小说专区| 国精品午夜福利视频| 免费观看男女性高视频| 无码人妻一区二区三区av | 人妻少妇精品无码专区| 欧美大肥婆大肥bbbbb| 欧美一区二区三区性视频| 天天天天噜在线视频| 亚洲国产精品无码久久sm| 久久国产精品波多野结衣av| 国产精品情侣呻吟对白视频| 重口sm一区二区三区视频| 十八岁污网站在线观看| 亚洲欧美日本久久综合网站| 国产亚洲日本精品无码| 浴室人妻的情欲hd三级国产| 一卡二卡三卡视频| 免费观看女人高潮视频软件| 国产精品久久久久久av福利| 国产乱xxⅹxx国语对白| 国产精品久久久一区二区| 午夜好爽好舒服免费视频| 青青视频免费观看免费| 色橹橹欧美在线观看视频高清| 337p粉嫩日本欧洲亚洲大胆| 男人边吻奶边挵进去视频| 任我爽橹在线视频精品583| 波多野结衣在线观看一码| 欧美va亚洲va在线观看日本| 又黄又湿啪啪响18禁| 艳妇荡女欲乱双飞两中年熟妇| 久久精品人妻一区二区蜜桃| 国产成人亚洲精品另类动态 | 日本高清色www网站色噜噜噜| 日本一道高清一区二区三区| 欧美深度肠交惨叫| 四虎成人精品无码永久在线| 亚洲第一天堂无码专区| 内射白浆一区二区在线观看| 亚欧洲精品在线视频免费观看| 国产九九99久久99大香伊|