在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXO3 Antibody

FBXO3 Antibody

  • 中文名稱：
    FBXO3兔多克隆抗體
  • 貨號：
    CSB-PA008495GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human FBXO3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 基因功能參考文獻(xiàn)：
    1. we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866
    2. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
    3. Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664
    4. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    5. controls TRAF adaptor stability to regulate inflammation PMID: 23542741
    6. Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13582

    OMIM: 609089

    KEGG: hsa:26273

    STRING: 9606.ENSP00000265651

    UniGene: Hs.406787



主站蜘蛛池模板： 亚洲精品av无码喷奶水网站| 欧美亚洲偷图色综合| 137裸交肉体摄影| 色偷偷久久一区二区三区| 成人爽a毛片免费| 久久精品国产99国产精品澳门| 熟女少妇内射日韩亚洲| 国产情侣草莓视频在线| 18禁真人抽搐一进一出免费 | 18禁超污无遮挡无码免费网站国产| 丰满少妇夜夜爽爽高潮水| 性一交一黄一片| 黑人大荫蒂高潮视频| 亚洲日韩欧洲无码av夜夜摸| 成人精品免费视频在线观看| 性色欲情网站iwww九文堂| 国产一区二区三区不卡av| 久碰久摸久看视频在线观看| 国产av高清无亚洲| 人人妻人人妻人人人人妻人人| 一个人在线观看免费视频www| 亚洲日本一区二区一本一道| 冲田杏梨av一区二区三区| 无码精品人妻一区二区三区98 | 国产午夜亚洲精品一区| 无码少妇一区二区浪潮av| 亚洲婷婷综合色高清在线| 中文www新版资源在线| 丰满多毛的陰户视频| 国产高清在线精品一区免费| 狠狠色综合tv久久久久久| 色欲av无码一区二区三区| 日韩综合亚洲色在线影院| 97夜夜澡人人爽人人| 国产成人精品优优av| 人妻少妇久久中文字幕456| 亚洲2020天天堂在线观看| 欧美乱强伦xxxx孕妇| 亚洲v欧美v国产v在线观看 | 欧美激情肉欲高潮视频| 久久久久蜜桃精品成人片|