在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXO3 Antibody, HRP conjugated

FBXO3 Antibody, HRP conjugated

  • 中文名稱：
    FBXO3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA892132LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 3 protein (276-376AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 基因功能參考文獻：
    1. we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866
    2. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
    3. Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664
    4. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    5. controls TRAF adaptor stability to regulate inflammation PMID: 23542741
    6. Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
  • 數據庫鏈接：

    HGNC: 13582

    OMIM: 609089

    KEGG: hsa:26273

    STRING: 9606.ENSP00000265651

    UniGene: Hs.406787



主站蜘蛛池模板： 日本乱亲伦视频中文字幕| 国产成人综合色视频精品| 蜜乳av久久久久久久久久久| 久久www成人免费直播| 国产伦久视频免费观看视频| 亚洲中文字幕无码一区二区三区 | 亚洲综合色噜噜狠狠网站超清| 婷婷激情综合色五月久久竹菊影视 | 色婷婷欧美在线播放内射| 无码人妻精品一区二区三区东京热| 日本丰满熟妇乱子伦| 亚洲国产精品无码专区影院| 色一情一乱一伦麻豆| 亚洲自偷自偷图片| 99精品热在线在线观看视频| 性色香蕉av久久久天天网| 97久久精品人人澡人人爽| 在线天堂www在线国语对白| 成人精品免费视频在线观看| 免费无码又爽又刺激聊天app| 久久久久女教师免费一区| 国产亚洲综合网曝门系列| 亚洲r成人av久久人人爽| 一本大道东京热无码一区| 欧美巨大黑人极品精男| 吃奶摸下高潮60分钟免费视频| 久久国内精品自在自线400部| 国产精品18久久久久久麻辣| 亚洲欧洲av无码专区| 亚洲不卡1卡2卡三卡入口| 欧美饥渴熟妇高潮喷水水 | 偷拍农村老熟妇xxxxx7视频| 四虎永久地址www成人| 狠狠躁夜夜躁人人爽蜜桃| 亚洲v国产v天堂a无码二区| 小泽玛利亚一区二区在线观看| 国产农村妇女精品一二区| 伊人久久丁香色婷婷啪啪| 色久悠悠婷婷综合在线亚洲| h肉动漫无码无修6080动漫网| 免费全部高h视频无码|