在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXO3 Antibody, HRP conjugated

FBXO3 Antibody, HRP conjugated

  • 中文名稱：
    FBXO3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA892132LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 3 protein (276-376AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 基因功能參考文獻：
    1. we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866
    2. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
    3. Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664
    4. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    5. controls TRAF adaptor stability to regulate inflammation PMID: 23542741
    6. Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
  • 數據庫鏈接：

    HGNC: 13582

    OMIM: 609089

    KEGG: hsa:26273

    STRING: 9606.ENSP00000265651

    UniGene: Hs.406787



主站蜘蛛池模板： 一本色道久久东京热| 中文字幕av无码不卡| 中文字幕精品久久久久人妻红杏ⅰ | 狠狠躁夜夜躁人人躁婷婷视频| 亚洲日韩中文字幕一区| 亚洲中文字幕久在线| 西西艺术人像摄影| 中文字幕人乱码中文| 中文乱码字慕人妻熟女人妻| 动漫精品啪啪一区二区三区| 中国xxxx做受视频| 亚洲精品一区二区国产精华液| 日韩人妻无码免费视频一区二区三区| 全部免费毛片在线播放| 午夜无码大尺度福利视频| 人人爽人人爽人人片a免费| 99精品众筹模特自拍视频| 国产人成视频在线视频| 人妻熟女av一区二区三区| 国产精品亚洲第一区在线观看| 97伦伦午夜电影理伦片| 国产精品无码素人福利| 中文有码人妻字幕在线| 午夜福利伦伦电影理论片在线观看| 丰满少妇弄高潮了www| 欧美黑人xxxx又粗又长| 亚洲色精品88色婷婷七月丁香 | 亚洲精品92内射| 麻豆av字幕无码中文| 伊人久久综合无码成人网| 亚洲a∨国产av综合av下载| 久久亚洲精品无码网站| 俺去啦俺来也五月天| 中文字幕人妻熟女人妻| 久久久欧美国产精品人妻噜噜 | 国产日产人妻精品精品| 日韩人妻无码一区二区三区久久99 | 高潮内射免费看片| 亚洲中文字幕人成乱码| 亚洲一区二区三区| 成人午夜又粗又硬又长|