在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXO3 Antibody, HRP conjugated

FBXO3 Antibody, HRP conjugated

  • 中文名稱：
    FBXO3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA892132LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 3 protein (276-376AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 基因功能參考文獻：
    1. we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866
    2. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
    3. Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664
    4. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    5. controls TRAF adaptor stability to regulate inflammation PMID: 23542741
    6. Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
  • 數據庫鏈接：

    HGNC: 13582

    OMIM: 609089

    KEGG: hsa:26273

    STRING: 9606.ENSP00000265651

    UniGene: Hs.406787



主站蜘蛛池模板： 无码人妻精一区二区三区| 97精品免费公开在线视频| 18禁止观看强奷免费国产大片| 久久久久人妻一区精品果冻| 亚洲五月天综合| 亚洲已满18点击进入在线看片| 69天堂人成无码免费视频| 国产高清露脸孕妇系列| 久久婷婷成人综合色| 在线视频免费观看爽爽爽| 亚洲国产成人久久综合三区| 亚洲国产成人无码av在线影院| 中文无码精品a∨在线| 少妇被躁爽到高潮无码人狍大战| 国内精品伊人久久久久777| 国产日韩欧美亚洲精品中字| 亚洲精品国产一区二区精华| 国产午夜鲁丝片av无码| 日韩毛片免费无码无毒视频观看| 亚洲日韩一页精品发布| 欧美极品video粗暴| 欧美黑人巨大videos极品| 欧美群交射精内射颜射潮喷| 少妇久久久久久久久久| 国产免费麻传媒精品国产av| 精品国产一区二区三区av色诱| 女人脱了内裤趴开腿让男躁| 国产手机在线精品| 国产一区二区怡红院| 亚洲欧美国产制服图片区| 粉嫩av国产一区二区三区| 中文字幕乱码免费看电影| 国产精品黄页免费高清在线观看 | 欧美精品videossex少妇| 欧美内射深插日本少妇| 岛国4k人妻一区二区三区| 国内乱码一线二线三线| 女人被强╳到高潮喷水在线观看 | 米奇影院888奇米色99在线| 伊人久久大香线蕉亚洲五月天| 天堂√最新版中文在线地址|