在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FBXO3 Antibody, Biotin conjugated

FBXO3 Antibody, Biotin conjugated

  • 中文名稱：
    FBXO3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA892132LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) FBXO3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    F Box G - Domain 3 antibody; F box only protein 3 antibody; F box protein 3 antibody; F box protein FBX3 antibody; F-box only protein 3 antibody; FBA antibody; FBX3 antibody; FBX3_HUMAN antibody; FBXO3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human F-box only protein 3 protein (276-376AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
  • 基因功能參考文獻：
    1. we report the X-ray structure of the human FBxo3 ApaG domain, residues 278-407, at 2.0 A resolution PMID: 27010866
    2. AIRE, which is phosphorylated on two specific residues near its N terminus, then binds to the F-box protein 3 (FBXO3) E3 ubiquitin ligase. In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE, increases its binding to the positive transcription elongation factor b (P-TEFb), and potentiates its transcriptional activity. PMID: 27365398
    3. Fbxo3 promotes the proteasomal degradation of Smurf1. Fbxo3 promotes the poly-ubiquitination of Smurf1. PMID: 25721664
    4. Virulence factor NSs of rift valley fever virus recruits the FBXO3 to degrade subunit p62 of general transcription factor TFIIH. PMID: 24403578
    5. controls TRAF adaptor stability to regulate inflammation PMID: 23542741
    6. Fbx3 formed SCF(Fbx3) ubiquitin ligase and promoted the degradation of HIPK2 and p300 by the ubiquitin-proteasome pathway PMID: 18809579

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies.
  • 數據庫鏈接：

    HGNC: 13582

    OMIM: 609089

    KEGG: hsa:26273

    STRING: 9606.ENSP00000265651

    UniGene: Hs.406787



主站蜘蛛池模板： 成人亚洲a片v一区二区三区动漫| 亚洲精品国产情侣av在线| 亚洲乱码日产精品bd在| 国产成人久久综合第一区| 欧美日韩视频无码一区二区三| 国产又色又爽又黄刺激在线视频| 欧美3p两根一起进高清免费视频| 成人电线在线播放无码| 成人乱码一区二区三区四区| 又色又爽又高潮免费视频观看| 久久精品久久电影免费理论片| 呻吟国产av久久一区二区| 亚洲一区二区无码影院| 特大黑人娇小亚洲女| 亚洲国产婷婷六月丁香 | 天堂资源中文最新版在线一区| 久久ee热这里只有精品| 午夜一区一品日本| 日本不卡高字幕在线2019| 人妻少妇被粗大爽.9797pw| 国产高清不卡免费视频| 久99久热只有精品国产15| 国产亚洲精品久久久久久久久动漫| 伊人久久精品在热线热| 亚洲国产精品一区二区手机| 国产色秀视频在线播放| 午夜精品一区二区三区的区别| 少妇被粗大的猛烈进出图片 | 人妻无码中文字幕一区二区三区| 天天av天天av天天透| 午夜精品久久久久久久99老熟妇| 欧美性受xxxx黑人xyx性爽| 欧美品无码一区二区三区在线蜜桃| 亚洲国产日韩制服在线观看| 亚洲成a人片在线观看国产| 亚洲日韩精品欧美一区二区一| 亚洲性人人天天夜夜摸| 久久无码中文字幕免费影院| 色欲色香天天天综合vvv| 看全色黄大色大片免费久久| 中文 在线 日韩 亚洲 欧美 |